Signalverhalten maligner und benigner Läsionen in der dynamischen 2D-MRT der Mamma

Abstract

In a retrospective study of 400 dynamic MR examinations of the breast the signal/time ratio of 62 histopathologically correlated lesions (19 benign, 42 malignant) was evaluated. Points of evaluation were initial signal enhancement (1st and 2nd minute), post-initial signal appearance (2nd to 5th minute) and signal distribution (homogeneous, marginal). Based on these criteria, a point system was defined to help in the assessment of lesions in dynamic breast-MR imaging. The overall sensitivity of this method was 95.3%, the specificity to 89.5% and the accuracy to 93.5%. Pitfalls resulted in two cases of non-invasive carcinoma and in two patients with fibroadenoma.

International investigation of breast MRI: results of a multicentre study (11 sites) concerning diagnostic parameters for contrast-enhanced MRI based on 519 histopathologically correlated lesions

“…6 Table 7 gives an overview of the features of the 5 and 2 carcinomas that were misclassified at 1.0 T by rules (a) and (b), respectively, and of the 25 and 9 carcinomas that were misclassified at 1. As shown in Table 7, no statistically significant difference in lesion size exists between the correctly and the incorrectly classified invasive carcinomas larger than 5 mm.…”

“…An increasing number of authors have confirmed the value of contrast-enhanced (CE) MRI for certain indications [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. However, accuracy data in the literature vary, and concern exists that a widespread use of CE MRI combined with insufficient standardization might cause costly work-up and unsatisfying results including false-positive and false-negative results.…”

Combination of low and high resolution sequences in two orientations for dynamic contrast-enhanced MRI of the breast: more than a compromise

“…(1) To achieve precise signal-time curves of contrast agent uptake within lesions, a series of T1-weighted sequences is used [9][10][11][12][13][14][15]. Mostly three-dimensional (3D) gradient recall echo (GRE) sequences with duration of 90 s or less are performed once before and several times after injection of contrast-media (CM).…”

Near‐infrared imaging of breast cancer using optical contrast agents

“…It is known from breast MRI that analysis of early contrast medium dynamics can provide crucial information for the differentiation between malignant and benign breast lesions [85][86][87]: malignant breast lesions tend to enhance much faster than benign lesions within the first minute of contrast medium administration. In optical mammography, analysis of early and very early contrast enhancement is of interest for the following reasons: 1) Despite ongoing technical developments in MR imaging, the temporal resolution achieved is still lower than that of optical techniques [88,89].…”