Signalment, Survival, and Prognostic Factors in Doberman Pinschers With End‐Stage Cardiomyopathy

Calvert, Clay A.; Pickus, Cynthia W.; Jacobs, G; Brown, Jack

doi:10.1111/j.1939-1676.1997.tb00474.x

Cited by 113 publications

(143 citation statements)

References 4 publications

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“…4,5 Only dogs with severe ventricular tachyarrhythmia nonresponsive to antiarrhythmic drugs that then were treated with amiodarone were included in this study. These dogs were studied because of an observation of toxicity that was characterized by lethargy, anorexia, vomiting, diarrhea, and hepatotoxicity associated with amiodarone administration.…”

Section: Discussionmentioning

confidence: 99%

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Toxicity in Doberman Pinchers with Ventricular Arrhythmias Treated with Amiodarone (1996–2005)

Kraus¹,

Thomason²,

Fallaw³

et al. 2009

Veterinary Internal Medicne

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Background: Asymptomatic Doberman Pinschers with dilated cardiomyopathy (DCM) often die suddenly owing to ventricular tachycardia that degenerates into ventricular fibrillation. A safe and effective antiarrhythmic drug treatment is needed. This will require a large, well-controlled, prospective study.Hypothesis: Amiodarone toxicity is common in Dobermans with occult DCM and ventricular tachyarrhythmias refractory to antiarrhythmia therapy. Infrequent monitoring of hepatic function is inadequate. Frequent monitoring may be useful to determine dogs in which the dosage should be decreased or the drug withdrawn.Methods: Medical records from the University of Georgia and Cornell University were searched for Doberman Pinschers diagnosed with preclinical DCM that received amiodarone for severe ventricular arrhythmias refractory to other antiarrhythmic agents. Echocardiographic data, Holter recording data, hepatic enzyme serum activity, and serum amiodarone concentrations were recorded. The presence of clinical signs of toxicity was recorded. Serum amiodarone concentrations were obtained in some dogs.Results: Reversible toxicity was identified in 10 of 22 (45%) dogs. Conclusion and Clinical Importance: Adverse effects from amiodarone were common and were, in part, dosage related. Patients should be monitored for signs of toxicity and liver enzyme activity should be measured at least monthly.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] The outcome in cardiomyopathic patients usually is either sudden death or congestive heart failure (CHF).…”

mentioning

confidence: 99%

Toxicity in Doberman Pinchers with Ventricular Arrhythmias Treated with Amiodarone (1996–2005)

Kraus¹,

Thomason²,

Fallaw³

et al. 2009

Veterinary Internal Medicne

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“…Survival rate at 1 year varied between 3 and 54% in different studies. 9,10,16,29,50,57,80,86,87,95 The wide variation in survival times may partly depend on different functional classes of CHF in different studies. Medical treatment, especially the use of angiotensin-converting enzyme inhibitors and ß-blocking agents, varied considerably between different studies, which also may be a source of variation in survival times.…”

Section: Survival and Prognosismentioning

confidence: 99%

Histologic Characterization of Canine Dilated Cardiomyopathy

Tidholm¹,

Jönsson

2005

Vet Pathol

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Abstract. Dilated cardiomyopathy (DCM), characterized by chamber dilatation and myocardial systolic and diastolic dysfunction, is one of the most common heart diseases in dogs. The clinical diagnosis is based on findings on echocardiographic and Doppler examinations, with the active exclusion of other acquired or congenital heart diseases. However, the echocardiographic criteria for the diagnosis of DCM are not wholly specific for the disease, and histologic examination may be necessary for final diagnosis. Review of reports on histologic findings in dogs with clinically diagnosed DCM reveals two histologically distinct forms of DCM: 1) cardiomyopathy of Boxers and Doberman Pinschers, corresponding to the ''fatty infiltration-degenerative'' type and 2) the form seen in many giant, large-, and medium-sized breeds, including some Boxers and Doberman Pinschers, classified as the ''attenuated wavy fiber'' type of DCM. The histologic changes of the attenuated wavy fiber type of DCM may precede clinical and echocardiographic signs of heart disease, thus indicating an early stage of DCM.

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“…Evidence suggests that benazepril might be beneficial in dogs with asymptomatic heart disease,22 but 2 trials23, 24 were not able to demonstrate a significant effect of enalapril on time to develop CHF. DCM is characterized by a slowly progressive presymptomatic phase during which ventricular premature contractions occur along with progressive left ventricular dysfunction and, usually, progressively more severe ventricular tachyarrhythmias 25, 26, 27. Outcome of dogs with DCM is usually either sudden death or CHF 25.…”

mentioning

confidence: 99%

Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs

Kraus

Rassnick

Wakshlag

et al. 2013

Veterinary Internal Medicne

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BackgroundVitamin D plays a pivotal role in cardiac function, and there is increasing evidence that vitamin D deficiency is associated with the development of congestive heart failure (CHF) in people.HypothesisSerum vitamin D concentration is lower in dogs with CHF compared with unaffected controls and serum vitamin D concentration is associated with clinical outcome in dogs with CHF.AnimalsEighty‐two client‐owned dogs.MethodsIn this cross‐sectional study, we examined the association between circulating 25‐hydroxyvitamin D [25(OH)D], a measure of vitamin D status, and CHF in dogs. In the prospective cohort study, we examined whether 25(OH)D serum concentration was associated with clinical outcome in dogs with CHF.ResultsMean 25(OH)D concentration (100 ± 44 nmol/L) in 31 dogs with CHF was significantly lower than that of 51 unaffected dogs (123 ± 42 nmol/L; P = .023). The mean calculated vitamin D intake per kg of metabolic body weight in dogs with CHF was no different from that of unaffected dogs (1.37 ± 0.90 μg/kg metabolic body weight versus 0.98 ± 0.59 μg/kg body weight, respectively, P = .097). There was a significant association of serum 25(OH)D concentration on time to clinical manifestation of CHF or sudden death (P = .02).Conclusion and Clinical RelevanceThese findings suggest that low concentrations of 25(OH)D may be a risk factor for CHF in dogs. Low serum 25(OH)D concentration was associated with poor outcome in dogs with CHF. Strategies to improve vitamin D status in some dogs with CHF may prove beneficial without causing toxicity.

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Signalment, Survival, and Prognostic Factors in Doberman Pinschers With End‐Stage Cardiomyopathy

Cited by 113 publications

References 4 publications

Toxicity in Doberman Pinchers with Ventricular Arrhythmias Treated with Amiodarone (1996–2005)

Toxicity in Doberman Pinchers with Ventricular Arrhythmias Treated with Amiodarone (1996–2005)

Histologic Characterization of Canine Dilated Cardiomyopathy

Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs

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