Signalment differences in bone mineral content and bone mineral density in canine appendicular bones

Lorinson, Karin; Loebcke, Sabine; Skalicky, Monika; Grampp, S.; Lorinson, D.

doi:10.3415/vcot-07-01-0009

Cited by 15 publications

(1 citation statement)

References 10 publications

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“…Although unreported in veterinary literature, the validity of measuring t bones for assessment of bone density has been well explored in the human field Bone mineral density of the skull bones is well correlated to the rest of the skele The measurement of BMD from the vertebral column, hips and wrists in people number of technical uncertainties that make skull bone density measurements m pealing [29][30][31][32]. The qCT imaging technique featured in this paper was easy to and results obtained were in keeping with previous cadaveric studies [33].…”

Section: Discussionmentioning

confidence: 99%

Computed Tomography Osteodensitometry for Assessment of Bone Mineral Density of the Canine Head—Preliminary Results

Woods

Israeliantz

Handel

et al. 2021

Animals

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Despite bone mineral density (BMD) being regularly measured in human patients, BMD studies in clinical cohorts of dogs is lacking. In order to facilitate BMD assessment and in turn better identify dogs suffering from metabolic bone disease, rapid, easy and precise computed tomography (qCT) techniques are required. In this study we aimed to assess the utility of quantitative computed tomography (qCT) bone mineral density (BMD) measurement of the canine calvarium using a semiautomated osteodensitometry software and define host factors associated with canine bone mineral density in a skeletally healthy population. Calvarial qCT at the level of the temporomandibular joints was performed on 323 dogs using a dedicated osteodensitometry calibration phantom during a clinically indicated head computed tomography (CT). Calvarial BMD was analyzed using a dedicated semiautomatic osteodensitometry software for contouring of the calvarial lamellar bone margins and BMD calculation. The mean duration of the calvarial qCT scanning was 64.6 s, and the mean duration of BMD analysis was 34 s, with a mean of two manual adjustments required for the bone margin tracing. The median BMD of all dogs in our study was 659 mg Calcium hydroxyapatite/mL. There was a negative linear correlation between BMD and body weight, but no correlation with age, sex or neutered status. Canine BMD assessment using qCT of the calvarium is a practical and fast technique that can be added to a clinical CT examination with minimal extra time requirements. Canine BMD host-dependent factors exhibit different relationships from that of humans; however, further investigation is warranted.

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Section: Discussionmentioning

confidence: 99%

Computed Tomography Osteodensitometry for Assessment of Bone Mineral Density of the Canine Head—Preliminary Results

Woods

Israeliantz

Handel

et al. 2021

Animals

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Comparative investigation of bone mineral density using CT and DEXA in a canine femoral model

Lucas

Behrens

Nolte

et al. 2017

Journal Orthopaedic Research

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Bone density measurements using computed tomography (CT) instead of dual-energy X-ray absorptiometry (DEXA) are currently of great interest in human and veterinary medical research as it would be beneficial to use CT scans obtained for other indications also for determining bone density. For Hounsfield units (HU) measured with CT in specific regions of interests (ROIs) in one or several slice/s a correlation with bone mineral density (BMD) measured by DEXA in humans and dogs of between 0.44 and 0.77 is reported in the literature. In the present study, instead certain volumes of interest (VOIs) obtained by CT scan and the corresponding HU to the respective VOIs were compared with the bone mineral density of the corresponding areas measured by DEXA. The aim of the study was to investigate whether this procedure gives more accurate information about bone density of the bones as three-dimensional objects of the respective patient. Correlation between measured HU in the respective VOI and BMD measured with DEXA in the corresponding ROI showed a very good correlation of 0.93. Linear regression with R = 0.85 (p = 0.0262) was calculated. Except for VOI5, similar distribution of values and significant differences (p < 0.0001-0.0087) between ROIs/VOIs were detected. Determining HU for assessing bone mineral density in a certain volume provides more accurate results than those previously reported from two-dimensional (2D) CT measurements. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2667-2672, 2017.

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Timing of orthodontic tooth movement in bone defects repaired with synthetic scaffolds: A scoping review of animal studies

Tsai

Wahab

Yazid

2021

Archives of Oral Biology

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Signalment differences in bone mineral content and bone mineral density in canine appendicular bones

Cited by 15 publications

References 10 publications

Computed Tomography Osteodensitometry for Assessment of Bone Mineral Density of the Canine Head—Preliminary Results

Computed Tomography Osteodensitometry for Assessment of Bone Mineral Density of the Canine Head—Preliminary Results

Comparative investigation of bone mineral density using CT and DEXA in a canine femoral model

Timing of orthodontic tooth movement in bone defects repaired with synthetic scaffolds: A scoping review of animal studies

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