Signalling dynamics in embryonic development

Sonnen, Katharina F.; Janda, Claudia Y.

doi:10.1042/bcj20210043

Cited by 25 publications

(18 citation statements)

References 249 publications

(346 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Around E7.0 for humans and E5.0 in mice, the three lineages (TE, EPI and hypoblast/PrE) of the blastocyst are defined and the embryo is ready to implant in the uterine wall ( Figure 1A ) ( Braude et al, 1988 ; Rossant and Tam, 2017 ). Signaling events regulating early development have been extensively studied over the last decades and have been thoroughly reviewed elsewhere ( Perrimon et al, 2012 ; Menchero et al, 2017 ; Sonnen and Janda, 2021 ). This deep knowledge of the signaling milieu allowed researchers to recapitulate many stages of mouse and human embryonic development in vitro .…”

Section: The Role Of Epigenetics In Regulating Early Embryonic Develo...mentioning

confidence: 99%

Chromatin as a sensor of metabolic changes during early development

Pladevall‐Morera

Ż̷ylicz²

2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Cellular metabolism is a complex network of biochemical reactions fueling development with energy and biomass; however, it can also shape the cellular epigenome. Indeed, some intermediates of metabolic reactions exert a non-canonical function by acting as co-factors, substrates or inhibitors of chromatin modifying enzymes. Therefore, fluctuating availability of such molecules has the potential to regulate the epigenetic landscape. Thanks to this functional coupling, chromatin can act as a sensor of metabolic changes and thus impact cell fate. Growing evidence suggest that both metabolic and epigenetic reprogramming are crucial for ensuring a successful embryo development from the zygote until gastrulation. In this review, we provide an overview of the complex relationship between metabolism and epigenetics in regulating the early stages of mammalian embryo development. We report on recent breakthroughs in uncovering the non-canonical functions of metabolism especially when re-localized to the nucleus. In addition, we identify the challenges and outline future perspectives to advance the novel field of epi-metabolomics especially in the context of early development.

show abstract

Section: The Role Of Epigenetics In Regulating Early Embryonic Develo...mentioning

confidence: 99%

Chromatin as a sensor of metabolic changes during early development

Pladevall‐Morera

Ż̷ylicz²

2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Usually, one group of cells (the inducing tissue) influences the development of another set of cells (the responding tissue) in a process called induction [ 1 ]. Cell-to-cell communication is essential for induction, for the ability of a cell to respond, and to allow dialogue between inducing and responding cells [ 2 ]. Therefore, communication between cells is critical for embryonic development, and the main mechanisms that allow this communication are juxtracrine and paracrine signaling [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Connexins and Pannexins: Important Players in Neurodevelopment, Neurological Diseases, and Potential Therapeutics

et al. 2022

View full text Add to dashboard Cite

Cell-to-cell communication is essential for proper embryonic development and its dysfunction may lead to disease. Recent research has drawn attention to a new group of molecules called connexins (Cxs) and pannexins (Panxs). Cxs have been described for more than forty years as pivotal regulators of embryogenesis; however, the exact mechanism by which they provide this regulation has not been clearly elucidated. Consequently, Cxs and Panxs have been linked to congenital neurodegenerative diseases such as Charcot-Marie-Tooth disease and, more recently, chronic hemichannel opening has been associated with adult neurodegenerative diseases (e.g., Alzheimer’s disease). Cell-to-cell communication via gap junctions formed by hexameric assemblies of Cxs, known as connexons, is believed to be a crucial component in developmental regulation. As for Panxs, despite being topologically similar to Cxs, they predominantly seem to form channels connecting the cytoplasm to the extracellular space and, despite recent research into Panx1 (Pannexin 1) expression in different regions of the brain during the embryonic phase, it has been studied to a lesser degree. When it comes to the nervous system, Cxs and Panxs play an important role in early stages of neuronal development with a wide span of action ranging from cellular migration during early stages to neuronal differentiation and system circuitry formation. In this review, we describe the most recent available evidence regarding the molecular and structural aspects of Cx and Panx channels, their role in neurodevelopment, congenital and adult neurological diseases, and finally propose how pharmacological modulation of these channels could modify the pathogenesis of some diseases.

show abstract

“…The temporal dynamics of gene expression are known to be a key factor in determining cell fate in many contexts [1][2][3]. Biological and technical advances (e.g., in fluorescent protein reporters and microscopy [4]) have meant that dynamic data has become increasingly abundant (for example, reviewed in [5]), yet dynamic gene expression remains difficult to measure and interpret [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Bilateral Feedback in Oscillator Model Is Required to Explain the Coupling Dynamics of Hes1 with the Cell Cycle

Rowntree

Sabherwal²,

Papalopulu

2022

Mathematics

View full text Add to dashboard Cite

Biological processes are governed by the expression of proteins, and for some proteins, their level of expression can fluctuate periodically over time (i.e., they oscillate). Many oscillatory proteins (e.g., cell cycle proteins and those from the HES family of transcription factors) are connected in complex ways, often within large networks. This complexity can be elucidated by developing intuitive mathematical models that describe the underlying critical aspects of the relationships between these processes. Here, we provide a mathematical explanation of a recently discovered biological phenomenon: the phasic position of the gene Hes1’s oscillatory expression at the beginning of the cell cycle of an individual human breast cancer stem cell can have a predictive value on how long that cell will take to complete a cell cycle. We use a two-component model of coupled oscillators to represent Hes1 and the cell cycle in the same cell with minimal assumptions. Inputting only the initial phase angles, we show that this model is capable of predicting the dynamic mitosis to mitosis behaviour of Hes1 and predicting cell cycle length patterns as found in real-world experimental data. Moreover, we discover that bidirectional coupling between Hes1 and the cell cycle is critical within the system for the data to be reproduced and that nonfixed asymmetry in the interactions between the oscillators is required. The phase dynamics we present here capture the complex interplay between Hes1 and the cell cycle, helping to explain nongenetic cell cycle variability, which has critical implications in cancer treatment contexts.

show abstract

Signalling dynamics in embryonic development

Cited by 25 publications

References 249 publications

Chromatin as a sensor of metabolic changes during early development

Chromatin as a sensor of metabolic changes during early development

Connexins and Pannexins: Important Players in Neurodevelopment, Neurological Diseases, and Potential Therapeutics

Bilateral Feedback in Oscillator Model Is Required to Explain the Coupling Dynamics of Hes1 with the Cell Cycle

Contact Info

Product

Resources

About