Signalisation cellulaire et physiopathologie de l’hypertension artérielle pulmonaire

Dao, Pierre; Montani, David; Duong‐Quy, Sy; Dinh-Xuan, Anh Tuan

doi:10.1016/s0761-8425(06)73418-0

Cited by 10 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The endothelial cells also synthesize endothelin with its three isoforms (ET-1, endothelin-2 [ET-2] and endothelin-3 [ET-3]) are all vasoconstrictors. The main differences between these three isoforms are due to their tissue expression and affinity for both membrane endothelin receptors: ET A receptors and ET B receptors [33]. The binding of ET-1 to the receptors ET A and ET B activates G protein coupled to phospholipase C, resulting an increase of intracellular calcium concentration, responsible for the contraction of the vascular smooth muscles ( Figure 2) [34].…”

Section: Endothelin-1 Signaling Pathwaymentioning

confidence: 99%

Physiopathology of Pulmonary Hypertension: from Bio-Molecular Mechanism to Target Treatment

Duong‐Quy¹

2016

Vasc Med Surg

View full text Add to dashboard Cite

Although the diagnosis and treatment of pulmonary hypertension (PH) is developed constantly in the last decade, PH remains an incurable and difficult to treat disease due to its high life disability and dreadful survival rate. The disease is characterized by sustained vasoconstriction, progressive vascular remodeling, and irreversible right heart dysfunction.The advanced knowledge in physiopathology and classification of PH in recent years is a useful tool helping physicians to improve the choice of target treatment. In addition, the remarkable progresses in understanding the molecular and cellular mechanisms of PH allow to develop new treatments. Actually, new therapeutic molecules have been discovered and their mechanisms of action are better understood and some are in preclinical and clinical trials. Preliminary results of these molecules with benefit effects on pulmonary arterial pressure and systemic hemodynamic gives a new hope for the future.

show abstract

Section: Endothelin-1 Signaling Pathwaymentioning

confidence: 99%