2010
DOI: 10.1128/iai.00342-10
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Signaling through C/EBP Homologous Protein and Death Receptor 5 and Calpain Activation Differentially Regulate THP-1 Cell Maturation-Dependent Apoptosis Induced by Shiga Toxin Type 1

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Cited by 22 publications
(21 citation statements)
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“…We have also reported that Stx1 treatment of differentiated THP-1 cells led to the increased expression of the apoptosis-inducing factor TRAIL and its receptor DR5 (TRAIL-R2). Signaling through TRAIL-DR5 engagement and the activation of calpains may contribute to the cleavage of procaspase-8 that we detected in Stx-treated THP-1 cells (Lee et al , 2010). …”
Section: Discussionmentioning
confidence: 77%
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“…We have also reported that Stx1 treatment of differentiated THP-1 cells led to the increased expression of the apoptosis-inducing factor TRAIL and its receptor DR5 (TRAIL-R2). Signaling through TRAIL-DR5 engagement and the activation of calpains may contribute to the cleavage of procaspase-8 that we detected in Stx-treated THP-1 cells (Lee et al , 2010). …”
Section: Discussionmentioning
confidence: 77%
“…We previously showed that Stxs induced calpain activation (cleavage) in D-THP-1 cells and calpains contributed to apoptosis (Lee et al , 2008, Lee et al, 2010). Treatment of HK-2 cells with Stx-2 led to a dose-dependent increase in levels of 28 kDa cleaved calpain fragments 24 h after intoxication (Figure 7A).…”
Section: Resultsmentioning
confidence: 99%
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“…Stxs also activate the ER stress response, which is normally triggered by the accumulation of misfolded proteins within the ER (18). Prolonged activation of ER stress is associated with the induction of apoptosis (18,19). Although the stress responses activated by Stxs appear to be cell type specific, the maturation state of a given cell may determine its cellular response to intoxication.…”
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confidence: 99%