Signaling Systems in Oral Bacteria

Miller, Daniel P.; Lamont, Richard J.

doi:10.1007/978-3-030-28524-1_3

Cited by 9 publications

(8 citation statements)

References 101 publications

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“…This oral microbiome can remain in mutualistic balance with the host or can cause dysbiosis resulting in an increased risk of diseases, such as dental caries and periodontitis. [64][65][66] Nevertheless, compared with the traditional articles from domain experts, the analyses in this paper have certain limitations, for example, the first name and last name of authors cannot be distinguished clearly in the map generated by CiteSpace.…”

Section: Discussionmentioning

confidence: 97%

Visualized analysis of trends and hotspots in global oral microbiome research: A bibliometric study

Liao

Peng

et al. 2020

MedComm

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The oral microbiome contains numerous bacteria, which directly or indirectly participate in various human functions and continuously exchange signals and substances with the human body, significantly affecting human life cycle, health, and disease. This study aimed to conduct bibliometric studies on the scientific outputs of global oral microbiome research by Citespace software. The data were obtained from the Thomson Reuters' Web of Science Core Collection (WoSCC), from the first relevant literature published until December 31st, 2019, and a total of 2225 articles and reviews were identified. The top country and institutions are the United States and Harvard University. Keywords analysis showed that periodontal disease, oral microbes, and dental plaque are research hotspots. The burst word analysis indicates that early childhood caries, squamous cell carcinoma, gut microbiome, Helicobacter pylori, Candida albicans, and dysbiosis are likely to become the research hotspots of the next era. We also recommend the use of knowledge mapping methods to track specific knowledge areas efficiently and objectively regularly, which can accurately identify hotspots and frontiers and provide valuable information for practitioners in the field, including related scientists, students, journals, and editors.

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Section: Discussionmentioning

confidence: 97%

Visualized analysis of trends and hotspots in global oral microbiome research: A bibliometric study

Liao

Peng

et al. 2020

MedComm

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“…Bacterial adaptation to environmental cues is often mediated by two‐component signal transduction systems (TCS) in which, canonically, a transmembrane sensor histidine kinase (HK) phosphorylates and activates a DNA‐binding response regulator (RR). Variations on this theme include hybrid systems in which the HK and RR are in the same molecule, and orphan systems in which the RR lacks a cognate HK (Miller & Lamont, 2019; Stock et al., 2000). Recently, it has become apparent that bacterial serine/threonine and tyrosine kinases can overlay cross‐phosphorylation interactions on signal transduction through TCS devices, particularly those involving orphan RRs where input from a HK may not occur (Desai & Kenney, 2017; Kalantari et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Role of the RprY response regulator in P. gingivalis community development and virulence

Shen

Perpich

Stocke

et al. 2020

Molecular Oral Microbiology

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Porphyromonas gingivalis, a keystone pathogen in periodontitis (Hajishengallis et al., 2012; Lamont et al., 2018), is an endogenous inhabitant of the oral cavity, in particular the subgingival space. This region is a complex and dynamic microhabitat containing a multispecies microbial community with a fluid phase of gingival crevicular fluid (Lamont et al., 2018). Bacterial adaptation to environmental cues is often mediated by two-component signal transduction systems (TCS) in which, canonically, a transmembrane sensor histidine kinase (HK) phosphorylates and activates a DNA-binding response regulator (RR). Variations on this theme include hybrid systems in which the HK and RR are in the same molecule, and orphan systems in which the RR lacks a cognate HK (Miller & Lamont, 2019; Stock et al., 2000). Recently, it has become apparent that bacterial serine/threonine and tyrosine kinases can overlay cross-phosphorylation interactions on signal

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“…Periodontal regeneration has its specificity, not only for the periodontal tissue's special structure, but also the bacteria environment of oral cavity. 16 Bacterial infection and immune response of the host can progressively destroy the integrity of components of periodontal tissue, the resorption of alveolar bone and attachment loss of periodontal ligament, result in the formation of periodontal pockets and the symptom of the tooth and gingival, 2 gingival recession and root surface exposure, and tooth loss ultimately. The inflamed tissue caused by bacterial should be controlled or eliminated before regenerate surgery.…”

Section: Periodontal Diseases Clinical Treatment and Specificitymentioning

confidence: 99%

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Ren

et al. 2020

J Biomater Appl

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Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.

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Signaling Systems in Oral Bacteria

Cited by 9 publications

References 101 publications

Visualized analysis of trends and hotspots in global oral microbiome research: A bibliometric study

Visualized analysis of trends and hotspots in global oral microbiome research: A bibliometric study

Role of the RprY response regulator in P. gingivalis community development and virulence

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

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