Signaling related with biphasic effects of bisphenol A (BPA) on Sertoli cell proliferation: A comparative proteomic analysis

Ge, Lichen; Chen, Zhuojia; Líu, Hao; Zhang, Kun-Shui; Qiao, Shan; Ma, Xiangyu; Huang, Huichao; Zhao, Zhenmin; Wang, Yuye; Giesy, John P.; Du, Jie; Wang, Hongsheng

doi:10.1016/j.bbagen.2014.05.018

Cited by 54 publications

(42 citation statements)

References 52 publications

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“…However, examination of the structure of BPA also illustrates its potential to act as a weak antioxidant via electron loss through the O‐H bond [Kadoma and Fujisawa, ; Kabuto et al, ; Chepelev et al, ]. Several reports have noted a reduction in ROS after BPA exposure and indicated the potential for ROS scavenging by BPA [Kabuto et al, ; Chepelev et al, ; Ge et al, ; Ponniah et al, ]. While the mechanisms underlying this effect have not been determined, contributing factors such as cellular microenvironment changes, cell type, and cell signaling responses could significantly contribute to the observed reduction in oxidative stress, as could differences in ROS measurement methods and time points [Kabuto et al, ; Chepelev et al, ; Ge et al, ; Ponniah et al, ].…”

Section: Induction Of Free Radicals and Oxidative Stress By Bpa Exposurementioning

confidence: 99%

“…Several reports have noted a reduction in ROS after BPA exposure and indicated the potential for ROS scavenging by BPA [Kabuto et al, ; Chepelev et al, ; Ge et al, ; Ponniah et al, ]. While the mechanisms underlying this effect have not been determined, contributing factors such as cellular microenvironment changes, cell type, and cell signaling responses could significantly contribute to the observed reduction in oxidative stress, as could differences in ROS measurement methods and time points [Kabuto et al, ; Chepelev et al, ; Ge et al, ; Ponniah et al, ]. However, it is interesting to note that like other polyphenolic compounds, BPA may maintain weak antioxidant activities.…”

Section: Induction Of Free Radicals and Oxidative Stress By Bpa Exposurementioning

confidence: 99%

“…Hyperpolarization of mitochondria was also observed over a range of BPA doses in HepG2 cells [Huc et al, ] and at 10 nM dosing of Sertoli cells [Ge et al, ]. Micromolar dosing of Sertoli cells with BPA resulted in less dense mitochondria with significant loss in membrane potential [Ge et al, ].…”

Section: Mitochondrial Dysfunctionmentioning

confidence: 99%

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Induction of oxidative stress by bisphenol A and its pleiotropic effects

Gassman

2017

Environ and Mol Mutagen

242

153

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Bisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer have emerged. BPA is a highly prevalent chemical in consumer products, and human exposure is thought to be ubiquitous. Numerous studies have demonstrated its endocrine disrupting properties and attributed exposure with cytotoxic, genotoxic, and carcinogenic effects; however, the results of these studies are still highly debated and a consensus about BPA's safety and its role in human disease has not been reached. One of the contributing factors is a lack of molecular mechanisms or modes of action that explain the diverse and pleiotropic effects observed after BPA exposure. The increase in BPA research seen over the last ten years has resulted in more studies that examine molecular mechanisms and revealed links between BPA-induced oxidative stress and human disease. Here, a review of the current literature examining BPA exposure and the induction of reactive oxygen species (ROS) or oxidative stress will be provided to examine the landscape of the current BPA literature and provide a framework for understanding how induction of oxidative stress by BPA may contribute to the pleiotropic effects observed after exposure.

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Section: Induction Of Free Radicals and Oxidative Stress By Bpa Exposurementioning

confidence: 99%

Section: Induction Of Free Radicals and Oxidative Stress By Bpa Exposurementioning

confidence: 99%

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Induction of oxidative stress by bisphenol A and its pleiotropic effects

Gassman

2017

Environ and Mol Mutagen

242

153

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“…The cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay according to the previous study [18]. Cells were seeded at a concentration of 2 × 10 3 /well in 96-well plates.…”

Section: Cell Viability Assaymentioning

confidence: 99%

Insufficient radiofrequency ablation promotes the growth of non-small cell lung cancer cells through PI3K/Akt/HIF-1α signals

Wan

Chen

et al. 2016

ABBS

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Accelerated progression of residual non-small cell lung cancer (NSCLC) after incomplete radiofrequency ablation (RFA) has frequently been reported. In this study, NSCLC cells A549, CCL-185, and H358 were treated using a water bath at 47°C for 5, 10, 15, 20, and 25 min gradually to establish the sublines A549-H, CCL-185-H, and H358-H, respectively. A549-H, CCL-185-H, and H358-H cells showed a significant increase in proliferation rate when compared with their corresponding parental cells in vitro. The expression of hypoxia-inducible factor-1α (HIF-1α) was obviously upregulated in both A549-H and CCL-185-H cells. Silencing of HIF-1α abolished the insufficient RFA-induced proliferation in A549-H and CCL-185-H cells. Furthermore, insufficient RFA treatment markedly elevated the phosphorylation of ERK1/2 and Akt, but not of p38 MAPK or JNK, in A549-H and CCL-185-H cells. The inhibitor of Akt, LY294002, but not the inhibitor of ERK1/2, PD98059, suppressed the upregulation of HIF-1α and the proliferation of A549-H and CCL-185-H cells in vitro. The in vivo results confirmed that insufficient RFA could trigger the tumor growth, upregulate the HIF-1α expression, and activate Akt in A549 xenograft tumors. Our data suggest that insufficient RFA can promote the in vitro and in vivo growth of NSCLC via upregulating HIF-1α through the PI3K/Akt signals.

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“…A recent study on human prostate stem-progenitor cells concluded that developmental exposure to BPA at low doses increases hormone-dependent cancer risk in the human prostate epithelium [10]. The list does not end here and includes testicular cancer [11], hepatic tumors [12], osteosarcoma [13] and endometrial carcinoma [14].…”

mentioning

confidence: 99%

Thermal printed receipts found to contain bisphenol: A potential carcinogen

Kapoor

Kumar

2014

Journal of the Egyptian National Cancer Institute

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Signaling related with biphasic effects of bisphenol A (BPA) on Sertoli cell proliferation: A comparative proteomic analysis

Cited by 54 publications

References 52 publications

Induction of oxidative stress by bisphenol A and its pleiotropic effects

Induction of oxidative stress by bisphenol A and its pleiotropic effects

Insufficient radiofrequency ablation promotes the growth of non-small cell lung cancer cells through PI3K/Akt/HIF-1α signals

Thermal printed receipts found to contain bisphenol: A potential carcinogen

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Signaling related with biphasic effects of bisphenol A (BPA) on Sertoli cell proliferation: A comparative proteomic analysis

Cited by 54 publications

References 52 publications

Induction of oxidative stress by bisphenol A and its pleiotropic effects

Induction of oxidative stress by bisphenol A and its pleiotropic effects

Insufficient radiofrequency ablation promotes the growth of non-small cell lung cancer cells through PI3K/Akt/HIF-1&alpha; signals

Thermal printed receipts found to contain bisphenol: A potential carcinogen

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Product

Resources

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Insufficient radiofrequency ablation promotes the growth of non-small cell lung cancer cells through PI3K/Akt/HIF-1α signals