“…It is also possible that while lymphomas are terminally differentiated tumors, leukemia has greater plasticity due to the tumor rising from less committed population of cells. Lymphomas have aberrant cell survival signal transduction pathways, including Bcl2, Bcl6, BRAF, TP53, NRAS, PI3K/AKT/mTOR signaling, BTK signaling, LYN/SYK signaling, JAK2/STAT, and PKCβ signaling pathways (96,97). Relapsed/refractory NHL cells resistant to apoptotic signals presented by native immune cells, and cytotoxic drugs, in addition to activation of prosurvival signaling, could also make lymphoma more resistant to CAR T cell therapy.…”