Signaling Pathways in Liver Cancer

Wu, Xiaohong; Li, Yang

doi:10.5772/31381

Cited by 7 publications

(7 citation statements)

References 126 publications

(165 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overexpression of EGFR occurs in about 40%-70% of conventional HCCs and is associated with more aggressive liver tumors, metastasis and poor patient survival [17,18,21,26,[32][33][34]. In our study we found that overexpression of EGFR significantly influenced survival of the patients (p<0.05), a finding that is consistent with other authors' reports.…”

Section: Discussionsupporting

confidence: 92%

“…Molecular mechanisms of oncogenic processes have been in the centre of attention of many researchers in the past few decades. Many cell signalling pathways are identified having an important role in tumor pathogenesis [21].…”

Section: Discussionmentioning

confidence: 99%

“…Wnt/β-catenin, VEGF (Vascular endothelial growth factor), FGF (Fibroblast Growth Factor), MAPK (Mitogen-activated protein kinase), PI3k/AKT/mTOR (Phosphoinositide 3 kinase/ mammalian target of rapamycin), EGFR (epidermal growth factor receptor), TGF-β (transforming growth factor-β) pathway and other pathways have been indicated in the development of many tumors. Understanding molecular mechanisms in carcinogenesis allows development of personalized target therapies that act directly and specifically on the components which regulate tumorigenesis [21].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

Nikolova

Chalovska

Ivanova

et al. 2018

Prilozi

View full text Add to dashboard Cite

Introduction: Epidermal growth factor receptor (EGFR) signaling plays an important role in various cancers, including hepatocellular carcinoma (HCC). We aimed to evaluate immunoexpression of EGFR in HCC and surrounding non-tumor liver tissue and to correlate it to multiple clinicopathologic data. Material and Methods: We analyzed 60 patients with HCC for multiple clinicopathologic characteristics and survival. Presence of the immunosignal and the percentage of positive tumor cells at the whole tumor tissue sample and adjacent cirrhotic liver tissue were semi-quantitatively determined. Results: Nineteen patients (31.67%) were female and 41 (68.33%) were male ranging in age from 31 to 85 years, median 61.88±10.51. Mean survival time for female patients was 8.86±1.76 months, for male 13.03±1.50 months and overall survival was 11.6051±1.19 months. The most patients had: T2 status (41.67%), no enlarged lymph nodes (90%), vascular invasion (63.33%) and well differentiated (43.33%) tumors. EGFR immunoexpression was determined in range from 0% to 100% in both tumor and non-tumor tissue with mean value of 39.58% in tumor and 86.86% in cirrhotic tissue (p<0.00). Higher percent of tumor EGFR positive cells were found in cases with higher T status, higher levels of AFP and poorly differentiated carcinoma, but not significantly. Lower percent of tumor EGFR positive cells were found in patients with vascular invasion and enlarged lymph nodes, but also not significantly. EGFR expression in tumor tissue significantly influenced survival of the patients (p<0.05). Conclusion: The study showed that expression of EGFR in lower percentage of tumor cells was associated to favorable prognosis, making it a potential prognostic marker and therapeutic target.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

Nikolova

Chalovska

Ivanova

et al. 2018

Prilozi

View full text Add to dashboard Cite

show abstract

“…7). Pi3K/AKT signaling is a major signaling pathway involved in tumorigenesis of hepatocellular carcinoma (Wu and Li, 2012). The tumor suppressor TP53 regulates cell cycle and initiates apoptosis upon extensive DNA damage thereby preventing cancer (Hussain et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis

Luckert

Hessel

Lenze

et al. 2015

Toxicology in Vitro

View full text Add to dashboard Cite

“…Although the current understanding on altered signaling pathways in HCC is far from complete, emerging evidence generated by using different model systems have improved our understanding that a confined subset of cell signaling pathways may be sequentially involved in hepatocarcinogenesis and tumor progression with metastasis [35][36][37]. In brief, these pathways play critical roles in controlling a wide range of essential biological processes required by the tumors in maintaining survival and adapting to the microenvironmental changes which includes Wnt/β-catenin, Notch and Hedgehog signaling pathways (differentiation and development), p53/p21 and RB1 signaling pathways (genomic stability and cell cycle regulation), EGF/EGFR, HGF/MET, IGF/IGFR, PI3K/AKT/mTOR and RAS/MAPK growth factor receptor signaling (cell proliferation and survival), VEGF/VEGFR, PDGF/PDGFR and FGF/FGFR signaling pathways (angiogen-esis), NFE2L2/KEAP1 signaling pathway (oxidative stress), ARID1A/ARID1B/ARID2 and MLL signaling pathways (chromatin regulation), and JAK/STAT signaling pathway (cytokine and growth factor signaling transduction).…”

Section: Altered Cell Signaling Pathwaysmentioning

confidence: 99%

Molecular Pathogenesis of Hepatocellular Carcinoma

Ho¹,

Lo²,

Chan³

et al. 2016

Liver Cancer

View full text Add to dashboard Cite

The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process involving the progressive accumulation of molecular alterations pinpointing different molecular and cellular events. The next-generation sequencing technology is facilitating the global and systematic evaluation of molecular landscapes in HCC. There is emerging evidence supporting the importance of cancer metabolism and tumor microenvironment in providing a favorable and supportive niche to expedite HCC development. Moreover, recent studies have identified distinct surface markers of cancer stem cell (CSC) in HCC, and they also put forward the profound involvement of altered signaling pathways and epigenetic modifications in CSCs, in addition to the concomitant drug resistance and metastasis. Taken together, multiple key genetic and non-genetic factors, as well as liver CSCs, result in the development and progression of HCC.

show abstract

Signaling Pathways in Liver Cancer

Cited by 7 publications

References 126 publications

Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

Immunohistochemical Expression of Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis

Molecular Pathogenesis of Hepatocellular Carcinoma

Contact Info

Product

Resources

About