Signaling pathways associated with bone loss in inflammatory bowel disease

Palatianou, Maria

doi:10.20524/aog.2023.0785

Cited by 3 publications

(5 citation statements)

References 74 publications

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“…The RANKL/RANK/OPG (Receptor Activator for Nuclear Factor κ B Ligand/Receptor Activator of Nuclear Factor κ B/Osteoprotegerin) pathway plays an important role in bone turnover, and it is activated by excessive inflammation in IBD [ 37 ]. Vitamin B, including vitamin B5 and folic acid, also play a role in osteoclastogenesis by influencing the RANKL/RANK/OPG pathway.…”

Section: Discussionmentioning

confidence: 99%

Impact of Folate Intake on Bone Mineral Density in Patients with Inflammatory Bowel Disease

Ratajczak-Pawłowska,

Szymczak-Tomczak,

Michalak

et al. 2023

Nutrients

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Background: Decreased bone mineral density (BMD) is a common problem among patients with inflammatory bowel disease (IBD). We hypothesised that an insufficient intake of folate might affect BMD. Methods: The study subjects included 26 with Crohn’s disease—CD, 30 with ulcerative colitis—UC, and 31 healthy adults (control group—CG) aged 18–50 years. Participants were asked to follow their usual diet, and dietary intake was assessed by a 4-day, 24 h dietary recall. All the participants filled in a questionnaire referring to folic acid supplementation. The BMD, T-score, and Z-score of the lumbar spine (L1–L4) and femoral neck (FN) were assessed. Results: We found significant differences in the body mass, BMI (body mass index), CRP (C-reactive protein), BMD, Z-score, and T-score of the L1–L4 and FN between groups. There were no differences in energy and folate intake or the percentage coverage of recommended dietary allowances (RDA) of folate in all groups. Moreover, 70% of patients with UC, 92% of patients with CD, and 77% of CG patients showed insufficient folate intake. Folic acid was supplemented with a similar frequency in patients covering and not covering the RDA of folate. The intake of folate per 1000 kcal correlated positively with the CD group’s BMD and T-score of L1–L4. Conclusions: Insufficient folate intake is common in patients with IBD and healthy individuals. The impact of folate on BMD in IBD is not clear. We need more studies on the association between folate intake, folic acid concentration, and BMD in IBD.

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Section: Discussionmentioning

confidence: 99%

Impact of Folate Intake on Bone Mineral Density in Patients with Inflammatory Bowel Disease

Ratajczak-Pawłowska,

Szymczak-Tomczak,

Michalak

et al. 2023

Nutrients

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“…Wnt/β-catenin activation leads to increased expression of genes related to bone formation and can exert anti-inflammatory effects in the bone. Wnt signaling pathway dysregulation has been found in intestinal mucosal samples from CD and UC patients [51]. Similarly, as in adipose tissue, irisin has been shown to target the Wnt signaling pathway in bone marrow mesenchymal stem cells.…”

Section: Irisin and Inflammatory Bowel Diseasementioning

confidence: 98%

“…OPG counteracts this effect by binding to receptor activators of NFκB receptors. An imbalance in the RANKL/OPG system is thought to be one of the main causes of bone loss in IBD patients [51]. The Wnt/β-catenin pathway has also been recognized to play a crucial role in bone mass regulation in IBD.…”

Section: Irisin and Inflammatory Bowel Diseasementioning

confidence: 99%

“…Poor oral hygiene, periodontitis, stomatitis, and dysbiosis have been linked to the development of diseases such as IBD and GI malignancies, including colorectal and esophageal cancer [57][58][59]. Proposed direct and indirect mechanisms behind this association include migration of activated T cells through the blood and lymphatic systems, local metabolism of carcinogens, oral-to-gut translocation of microorganisms, and generalized chronic inflammation caused by oral diseases [50][51][52].…”

Section: Irisin and Oral Healthmentioning

confidence: 99%

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The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract

Pinkas,

Brzozowski

2024

Antioxidants

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Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of exercise on health. Irisin may be a potential therapeutic agent against obesity and has been shown to play an important role in the protection of various cells, tissues, and organs due to its anti-inflammatory, antioxidative, and anti-cancer properties. Our aim was to review the recent experimental and clinical studies on irisin and its expression, release into the bloodstream, tissue targets, and potential contribution to the protective effects of exercise in the gastrointestinal tract. Particular emphasis was placed on inflammatory bowel disease, intestinal ischemia/reperfusion injury, periodontitis, and other digestive tract disorders, including carcinogenesis. Overall, irisin holds significant potential as a novel target molecule, offering a safe and therapeutic approach to treating various gastrointestinal diseases.

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“…Although beyond the scope of this paper, bone accrual is threatened in many pediatric chronic diseases, as well as by their accompanying medications. Recent review articles have been published on this topic [50][51][52][53][54][55][56][57].…”

Section: Andandmentioning

confidence: 99%

Bone mass accrual in children

Rodrick,

Kindler

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review Bone accrual during childhood and adolescence is critical for the attainment of peak bone mass and is a major contributing factor towards osteoporosis in later life. Bone mass accrual is influenced by nonmodifiable factors, such as genetics, sex, race, ethnicity, and puberty, as well as modifiable factors, such as physical activity and diet. Recent progress in bone imaging has allowed clinicians and researchers to better measure the morphology, density, and strength of the growing skeleton, thereby encompassing key characteristics of peak bone strength. In this review, the patterning of bone accrual and contributors to these changes will be described, as well as new techniques assessing bone mass and strength in pediatric research and clinical settings. Recent findings This review discusses factors influencing peak bone mass attainment and techniques used to assess the human skeleton. Summary The rate of bone accrual and the magnitude of peak bone mass attainment occurs in specific patterns varying by sex, race, ethnicity, longitudinal growth, and body composition. Physical activity, diet, and nutritional status impact these processes. There is a need for longitudinal studies utilizing novel imaging modalities to unveil factors involved in the attainment and maintenance of peak bone strength.

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Signaling pathways associated with bone loss in inflammatory bowel disease

Cited by 3 publications

References 74 publications

Impact of Folate Intake on Bone Mineral Density in Patients with Inflammatory Bowel Disease

Impact of Folate Intake on Bone Mineral Density in Patients with Inflammatory Bowel Disease

The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract

Bone mass accrual in children

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