Signaling Pathway Governed by Lipid Derived Molecules as Secondary Messenger

Abstract

Research shown that the cell death, particularly apoptosis, can extend beyond single cell boundaries. Gap junctions IP3 diffusion, and sphingolipids play significant roles in membrane biology and regulation of cell function. S1P plays crucial role in the cardiovascular and immune systems, serving as a mediator of signaling during cell migration, differentiation, proliferation, and apoptosis. Intestinal phospholipid metabolism, including 1B phospholipase A2 and autotaxin-mediated pathways, contributes to cardiometabolic diseases through multiple mechanisms. A potential strategy for treating cardiovascular and metabolic diseases is the therapeutic suppression of1B phospholipase A2 and autotaxin in the gastrointestinal tract. Cellular stress signalling, inflammation, resolution, and host defence responses are all significantly influenced by lysophospholipids such LPA and S1P. New therapies for cancer, vascular diseases, fibrotic disorders, and autoimmune diseases have been made possible by developments in lysophospholipid research.

Optimization of LC-MS/MS Analytical Method for Trace Level Quantification of Potential Genotoxic Impurities in Siponimod Pure Drug and Formulations

“…Int J Adv Life Sci Res. Volume 7(2)81-91 methanol and acetonitrile individually as diluent produce poor peak shape and poor recoveries respectively (Kundu & Halder 2024). Moreover, the equal combination of methanol and acetonitrile yields best peak symmetry with significantly high recoveries suggesting that this solvent composition was utilized as a diluent throughout the analysis.…”