Signaling Mechanisms of Transforming Growth Factor-β (TGF-β) in Cancer: TGF-β Induces Apoptosis in Lung Cells by a Smad-Dependent Mechanism

Lim, Mi Jung; Lin, T. J.; Jakowlew, Sonia B.

doi:10.5772/25948

Tumor Suppressor Genes 2012

DOI: 10.5772/25948

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Signaling Mechanisms of Transforming Growth Factor-β (TGF-β) in Cancer: TGF-β Induces Apoptosis in Lung Cells by a Smad-Dependent Mechanism

Mi Jung Lim¹,

T. J. Lin²,

Sonia B. Jakowlew³

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2014

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Kinase Signalling in Huntington's Disease

Bowles

Jones

2014

Journal of Huntington's Disease

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Alterations in numerous signal transduction pathways and aberrant activity of specific kinases have been identified in multiple cell and mouse models of Huntington's disease (HD), as well as in human HD brain. The balance and integration of a network of kinase signalling pathways is paramount for the regulation of a wide range of cellular and physiological processes, such as proliferation, differentiation, inflammation, neuronal plasticity and apoptosis. Unbalanced activity within these pathways provides a potential mechanism for many of the pathological phenotypes associated with HD, such as transcriptional dysregulation, inflammation and ultimately neurodegeneration. The characterisation of aberrant kinase signalling regulation in HD has been inconsistent and may be a result of failure to consider integration between multiple signalling pathways, as well as alterations that may occur over time with both age and disease progression. Collating the information about the effect of mHTT on signalling pathways demonstrates that it has wide ranging effects on multiple pro-and anti-apoptotic kinases, resulting in the dysregulation of numerous complex interactions within a dynamic network.

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Kinase Signalling in Huntington's Disease

Bowles

Jones

2014

Journal of Huntington's Disease

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Signaling Mechanisms of Transforming Growth Factor-β (TGF-β) in Cancer: TGF-β Induces Apoptosis in Lung Cells by a Smad-Dependent Mechanism

Cited by 1 publication

References 127 publications

Kinase Signalling in Huntington's Disease

Kinase Signalling in Huntington's Disease

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