Signaling Mechanisms by Arabidopsis Cryptochromes

Ponnu, Jathish; Hoecker, Ute

doi:10.3389/fpls.2022.844714

Cited by 39 publications

(33 citation statements)

References 158 publications

(251 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, the WDrepeat domain of PpSPAa is both necessary and sufficient for the interaction with the CCE domain of PpCRY1b. Moreover, the results suggest that PpCRY1b, as it was proposed for Arabidopsis CRYs (Ponnu & Hoecker, 2022), exhibits a 'closed conformation' in darkness that is opened by blue light exposure, thereby exposing the CCE domain for PpCOP1/PpSPA interaction.…”

Section: Ppspaa and Ppcop1a Interact With The Cce Domain Of Ppcry1bmentioning

confidence: 58%

“…In that regard, PpCRY1 behaved similar to Arabidopsis CRY1 and differently from Arabidopsis CRY2. In angiosperms, cryptochromes underwent a gene duplication event resulting in CRY1 and CRY2 with partially overlapping but distinct functions in Arabidopsis (Deppisch et al., 2022; Lariguet & Dunand, 2005; Ponnu & Hoecker, 2022). Importantly, they differ in their interactions with the SPA proteins: although the CCE domain of CRY1 interacts with the WD‐repeat domain of SPA1, CRY2 interacts via its PHR domain with the kinase domain of SPA1 (Lian et al., 2011; Liu et al., 2011; Zuo et al., 2011).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Co‐action of COP1, SPA and cryptochrome in light signal transduction and photomorphogenesis of the moss Physcomitrium patens

et al. 2023

Self Cite

View full text Add to dashboard Cite

SUMMARY The Arabidopsis COP1/SPA ubiquitin ligase suppresses photomorphogenesis in darkness. In the light, photoreceptors inactivate COP1/SPA to allow a light response. While SPA genes are specific to the green lineage, COP1 also exists in humans. This raises the question of when in evolution plant COP1 acquired the need for SPA accessory proteins. We addressed this question by generating Physcomitrium Ppcop1 mutants and comparing their visible and molecular phenotypes with those of Physcomitrium Ppspa mutants. The phenotype of Ppcop1 nonuple mutants resembles that of Ppspa mutants. Most importantly, both mutants produce green chloroplasts in complete darkness. They also exhibit dwarfed gametophores, disturbed branching of protonemata and absent gravitropism. RNA‐sequencing analysis indicates that both mutants undergo weak constitutive light signaling in darkness. PpCOP1 and PpSPA proteins form a complex and they interact via their WD repeat domains with the VP motif of the cryptochrome CCE domain in a blue light‐dependent manner. This resembles the interaction of Arabidopsis SPA proteins with Arabidopsis CRY1, and is different from that with Arabidopsis CRY2. Taken together, the data indicate that PpCOP1 and PpSPA act together to regulate growth and development of Physcomitrium. However, in contrast to their Arabidopsis orthologs, PpCOP1 and PpSPA proteins execute only partial suppression of light signaling in darkness. Hence, additional repressors may exist that contribute to the repression of a light response in dark‐exposed Physcomitrium.

show abstract

Section: Ppspaa and Ppcop1a Interact With The Cce Domain Of Ppcry1bmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Co‐action of COP1, SPA and cryptochrome in light signal transduction and photomorphogenesis of the moss Physcomitrium patens

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…This includes mitogen-activated protein kinase (MAPK) signaling ( Karia et al, 2021 ). The role of phosphorylation cascades during the interactions between photosynthesis and respiration, in particular, includes the participation of phytochrome and cryptochrome systems, in which the first step represents light-dependent phosphorylation of the protein moiety of phytochrome and cryptochrome ( Igamberdiev et al, 2014a , 2014b ; Ponnu and Hoecker, 2022 ).…”

Section: Multilevel Regulation Of Respiration In the Lightmentioning

confidence: 99%

Mitochondria in photosynthetic cells: Coordinating redox control and energy balance

Igamberdiev

Bykova

2022

Plant Physiology

View full text Add to dashboard Cite

In photosynthetic tissues in the light, the function of energy production is associated primarily with chloroplasts, while mitochondrial metabolism adjusts to balance ATP supply, regulate the reduction level of pyridine nucleotides, and optimize major metabolic fluxes. The tricarboxylic acid cycle in the light transforms into a non-cyclic open structure (hemicycle) maintained primarily by influx of malate and export of citrate to the cytosol. The exchange of malate and citrate forms the basis of feeding redox energy from the chloroplast into the cytosolic pathways. This supports the level of NADPH in different compartments, contributes to the biosynthesis of amino acids, and drives secondary metabolism via the supply of substrates for 2-oxoglutarate dioxygenase and for cytochrome P450-catalyzed monooxygenase reactions. This results in the maintenance of redox and energy balance in photosynthetic plant cells and in the formation of numerous bioactive compounds specific for any particular plant species. The non-coupled mitochondrial respiration operates in coordination with the malate and citrate valves and supports intensive fluxes of respiration and photorespiration. The metabolic system of plants has features associated with remarkable metabolic plasticity of mitochondria that permit the use of energy accumulated in photosynthesis in a way that all anabolic and catabolic pathways become optimized and coordinated.

show abstract

“…The cryptochrome photolyase family (CPF) includes: DNA photolyases—enzymes that repair DNA damaged by UVB (280–320 nm) under the action of near UV and blue light (320–480 nm) [ 222 , 232 , 233 , 234 ] and cryptochromes—receptor proteins for near UV and blue light. Cryptochromes carry out photoregulation of transcription for various genes and also participate in circadian rhythms [ 232 , 234 , 235 ] and magnitoreception [ 236 ].…”

Section: Biochemical and Physiological Application Of Pterin Photoche...mentioning

confidence: 99%

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Buglak

Kapitonova

Vechtomova

et al. 2022

IJMS

View full text Add to dashboard Cite

Pterins are an inseparable part of living organisms. Pterins participate in metabolic reactions mostly as tetrahydropterins. Dihydropterins are usually intermediates of these reactions, whereas oxidized pterins can be biomarkers of diseases. In this review, we analyze the available data on the quantum chemistry of unconjugated pterins as well as their photonics. This gives a comprehensive overview about the electronic structure of pterins and offers some benefits for biomedicine applications: (1) one can affect the enzymatic reactions of aromatic amino acid hydroxylases, NO synthases, and alkylglycerol monooxygenase through UV irradiation of H4pterins since UV provokes electron donor reactions of H4pterins; (2) the emission properties of H2pterins and oxidized pterins can be used in fluorescence diagnostics; (3) two-photon absorption (TPA) should be used in such pterin-related infrared therapy because single-photon absorption in the UV range is inefficient and scatters in vivo; (4) one can affect pathogen organisms through TPA excitation of H4pterin cofactors, such as the molybdenum cofactor, leading to its detachment from proteins and subsequent oxidation; (5) metal nanostructures can be used for the UV-vis, fluorescence, and Raman spectroscopy detection of pterin biomarkers. Therefore, we investigated both the biochemistry and physical chemistry of pterins and suggested some potential prospects for pterin-related biomedicine.

show abstract

Signaling Mechanisms by Arabidopsis Cryptochromes

Cited by 39 publications

References 158 publications

Co‐action of COP1, SPA and cryptochrome in light signal transduction and photomorphogenesis of the moss Physcomitrium patens

Co‐action of COP1, SPA and cryptochrome in light signal transduction and photomorphogenesis of the moss Physcomitrium patens

Mitochondria in photosynthetic cells: Coordinating redox control and energy balance

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Contact Info

Product

Resources

About