Signaling and Mechanical Roles of E-cadherin

Bhatt, Tanay; Rizvi, Abrar; Batta, Surya Prakash Rao; Kataria, Sunny

doi:10.3109/15419061.2013.854778

Cited by 54 publications

(42 citation statements)

References 104 publications

(118 reference statements)

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“…CXXC5 can interact with and inhibit the wingless type MMTV integration/β-catenin signaling pathway expressed in human trophoblastic cells [19, 20]. Mainly localized to cell-cell junctions, β-catenin plays an important role in intercellular adhesion, cell polarity, and architecture by binding to E-cadherin [21, 22]. Compared with non-pregnant tubal tissues, immunohistochemistry demonstrated that β-catenin was strongly expressed at tubal implantation sites in EPs following IVF-ET [23].…”

Section: Discussionmentioning

confidence: 99%

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

et al. 2017

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The incidence of ectopic pregnancy after assisted reproductive technology is increased approximately 2.5–5-fold compared with natural conceptions.Strategies were used to decrease the incidence of ectopic pregnancy, but ectopic pregnancy still occurs. In the present study, women were selected with decreased ovarian reserve (defined as FSH > 10 IU/L) aged 20 to 38 years who underwent IVF-ET between 2009 and 2014. These 2,061 women were age-matched with an equal number of women with normal ovarian reserve (defined as FSH ≤ 10 IU/L). During cycles following fresh embryo transfer, 93 patients were diagnosed with ectopic pregnancy. The incidence of ectopic pregnancy in clinical pregnancies was significantly higher in the decreased ovarian reserve than in the normal ovarian reserve group (5.51% vs. 2.99%). After adjusting for confounding factors, the incidence of ectopic pregnancy was significantly associated with decreased ovarian reserve. Our results showed that decreased ovarian reserve is an independent risk factor for ectopic pregnancy after in vitro fertilization-embryo transfer.

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Section: Discussionmentioning

confidence: 99%

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

et al. 2017

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“…TJs are composed of both cytosolic (i.e., zonula occludens) and integral membrane proteins (i.e., occludin, claudins). Adjacent to the TJ is the adherens junction (AJ), composed of E-cadherin and cadherin/catenin complexes that are linked with the actin cytoskeleton (23). The cytoskeletal links that support apical epithelial junctions are among the most highly ordered arrays of actin filaments in nature (24).…”

Section: Molecular Aspects Of Barrier Regulation In the Mucosamentioning

confidence: 99%

Oxygen metabolism and barrier regulation in the intestinal mucosa

Glover¹,

Lee²,

Colgan³

2016

Journal of Clinical Investigation

135

108

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“…Immediately below the TJs are the cadherin-rich AJs that mediate strong cell-to-cell adhesion and have functional roles in forming and regulating the epithelial barrier (15). The AJ E-cadherin integrates various intracellular and extracellular signals and plays an important role in the control of epithelial paracellular permeability (16,17). TJs and AJs are highly dynamic, and their constituent proteins undergo continuous remodeling and turnover under tight regulation by numerous extracellular and intracellular factors.…”

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confidence: 99%

H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR

Zou

Jaladanki

Liu

et al. 2016

Molecular and Cellular Biology

129

118

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The disruption of the intestinal epithelial barrier function occurs commonly in various pathologies, but the exact mechanisms responsible are unclear. The H19 long noncoding RNA (lncRNA) regulates the expression of different genes and has been implicated in human genetic disorders and cancer. Here, we report that H19 plays an important role in controlling the intestinal epithelial barrier function by serving as a precursor for microRNA 675 (miR-675). H19 overexpression increased the cellular abundance of miR-675, which in turn destabilized and repressed the translation of mRNAs encoding tight junction protein ZO-1 and adherens junction E-cadherin, resulting in the dysfunction of the epithelial barrier. Increasing the level of the RNA-binding protein HuR in cells overexpressing H19 prevented the stimulation of miR-675 processing from H19, promoted ZO-1 and E-cadherin expression, and restored the epithelial barrier function to a nearly normal level. In contrast, the targeted deletion of HuR in intestinal epithelial cells enhanced miR-675 production in the mucosa and delayed the recovery of the gut barrier function after exposure to mesenteric ischemia/reperfusion. These results indicate that H19 interacts with HuR and regulates the intestinal epithelial barrier function via the H19-encoded miR-675 by altering ZO-1 and E-cadherin expression posttranscriptionally.T he majority of the mammalian genome is transcribed into a vast number of noncoding RNAs, whereas protein-coding transcripts account for only a minority of transcriptional output (1, 2). Long noncoding RNAs (lncRNAs) are defined as transcribed RNAs spanning Ͼ200 nucleotides in length that lack protein-coding capacity and are distinct from well-characterized structural RNAs (rRNAs, tRNAs, snRNAs, and snoRNAs) or small regulatory RNAs (3, 4). lncRNAs arise from intergenic, antisense, or promoter-proximal regions, and they share many features with mRNAs. Both classes of RNA can be transcribed from multiexonic genes and possess a 5=-methyl-guanosine cap and 3=-poly(A) tail (1,3,5). Some lncRNAs are ubiquitous, but others are dynamically expressed in tissue-, differentiation stage-, and cell type-specific patterns (4, 6). lncRNAs have been involved in a variety of cellular functions, physiologic processes, and disease states by modulating gene expression at different levels, including chromatin remodeling, transcriptional and posttranscriptional control, and protein metabolism (1, 3, 4). lncRNAs can serve as repressors or activators of gene transcription, as has been extensively reported (1, 4), but lncRNAs also can regulate mRNA decay and translation, working jointly with microRNAs (miRNAs) and RNA-binding proteins (RBPs) (7-9).Intercellular junction complexes, comprising tight junctions (TJs) and adherens junctions (AJs), fence the paracellular space in simple epithelia, such as those lining the intestine, kidneys, and lung, and form an important barrier against a wide array of noxious substances present in the lumen (10, 11). In the intestine, the disruption...

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Signaling and Mechanical Roles of E-cadherin

Cited by 54 publications

References 104 publications

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve

Oxygen metabolism and barrier regulation in the intestinal mucosa

H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR

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