Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Convergences and divergences among eukaryotic kingdoms

Delage, Elise; Puyaubert, Juliette; Zachowski, Alain; Ruelland, Éric

doi:10.1016/j.plipres.2012.08.003

Cited by 85 publications

(84 citation statements)

References 205 publications

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“…However, the question of whether yeast Tor2 signalling affects synthesis of ergosterol or its physiological function is of interest to be explored. Third, the phosphoinositide PI(4,5)P 2 is an essential component of the plasma membrane (Delage et al 2013) that interacts with the MCC/eisosome proteins Slm1 and Slm2 to signal downstream to the actin cytoskeleton in conjunction with the Slm proteins' activator TORC2 (Audhya et al 2004;Fadri et al 2005). Karotki et al previously showed that the significance of PI(4,5)P 2 for the integrity of MCC, with the finding that MCC organization was severely compromised upon the disruption of PI(4,5)P 2 (Karotki et al 2011).…”

Section: Discussionmentioning

confidence: 99%

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

et al. 2015

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The elucidation of the organization and maintenance of the plasma membrane has been sought due to its numerous roles in cellular function. In the budding yeast Saccharomyces cerevisiae, a novel paradigm has begun to emerge in the understanding of the distribution of plasma membrane microdomains and how they are regulated. We aimed to investigate the dynamic interdependence between the protein complexes eisosome and TORC2, representing microdomains MCC and MCT, respectively. In this study, we reveal that the eisosome organizer Pil1 colocalizes with the MCT marker Avo2. Furthermore, we provide evidence that the formation of MCT is dependent on both eisosome integrity and adequate levels of the plasma membrane phosphoinositide PI(4,5)P2. Taken together, our findings indicate that TORC2, eisosomes, and PI(4,5)P2 exist in an interconnected relationship, which supports the emerging model of the plasma membrane.

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Section: Discussionmentioning

confidence: 99%

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

et al. 2015

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“…PI-4-P is formed through the phosphorylation of membrane phospholipid PI by phosphatidylinositol 4-kinase, whereas PI-4,5-P 2 , a substrate of PI-PLC, is generated by subsequent phosphorylation of PIP by phosphatidylinositol monophosphate 5-kinase (PIP5К) (Delage et al 2013). An increase in PIP5K activity in membranes of elongating lower halves of pulvini occurs at the same time as the second phase of IP 3 increase (Perera et al 1999).…”

Section: Phosphatidylinositol Phosphate Kinasesmentioning

confidence: 99%

Molecular mechanisms of gravity perception and signal transduction in plants

et al. 2015

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Gravity is one of the environmental cues that direct plant growth and development. Recent investigations of different gravity signalling pathways have added complexity to how we think gravity is perceived. Particular cells within specific organs or tissues perceive gravity stimulus. Many downstream signalling events transmit the perceived information into subcellular, biochemical, and genomic responses. They are rapid, non-genomic, regulatory, and cell-specific. The chain of events may pass by signalling lipids, the cytoskeleton, intracellular calcium levels, protein phosphorylation-dependent pathways, proteome changes, membrane transport, vacuolar biogenesis mechanisms, or nuclear events. These events culminate in changes in gene expression and auxin lateral redistribution in gravity response sites. The possible integration of these signalling events with amyloplast movements or with other perception mechanisms is discussed. Further investigation is needed to understand how plants coordinate mechanisms and signals to sense this important physical factor.

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“…InsP3 and DAG generation by PtdIns-4,5-P2 hydrolysis, together with the activation of calcium release and PKC, generated by these second messengers, have been the pathways reported to be responsible for this phosphoinositide participation in hormone signaling and exocytosis [20,21]. More recently different authors have demonstrated that phosphoinositides and especially PtdIns-4-P and PtdIns-4,5-P2 are not only precursors of second messengers but also directly interact with many protein effectors and their localisation and/or activity [3,22]. Although muscarinic stimulation of PLC-coupled M1 receptors in neurons leads to PtdIns-4,5-P2 hydrolysis, InsP3 release and diacylglycerol (DAG) generation, almost none Ca 2+ rises were detected as the result of such stimulation.…”

Section: Ptdins-45-p2mentioning

confidence: 99%

“…Fonovich de Schroeder and Pechén de D'Angelo [73] then performed a new assay to study the effects of Dieldrin on the glycerol moiety of phospholipids and acylglycerols and in fatty acids exchange from these molecules. 3 …”

Section: Organochlorine Pesticides Effectsmentioning

confidence: 99%

“…Major similarities between mammalian, yeast and higher plant phosphoinositide signaling reveal the early appearance and evolutionary conservation of this language. However, there have also been found major differences that suggest that organisms may have evolved different PtdIns-4-P and PtdIns-4,5-P2 functions [3]. The aim of the present review is to report an actualization of both the basic research on phospholipid and phosphoinositide phosph-orylation and hydrolysis pathways and some effects of organophosphate and organochlorine pesticides that have been described on these pathways.…”

Section: Introductionmentioning

confidence: 98%

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Phosphoinositide and phospholipid phosphorylation and hydrolysis pathways<br/>—Organophosphate and organochlorine pesticides effects<br>

Fonovich

Magnarelli²

2013

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Phospholipid and phosphoinositide phosphorylation pathways have been shown to be of crucial importance on producing lipid mediators. The earlier findings reported on lipid molecules playing roles in different metabolic pathways used to assign them the exclusive role of second messenger generators. Several researchers have recently described how direct interaction of phospholipids and phosphoinositides with molecules or organelles, without the need for producing second messenger molecules, is responsible for their mechanism of action. Organophosphate and organochlorine pesticide toxicity mechanisms have been extensively studied in relation to their well known effects on cholinesterase activities and on the alterations of electric activity in the nervous system of different organisms respectively. There is little but consistent evidence that some compounds, including in both groups of pesticides, are also able to interact with phospholipid and phosphoinositide phosphorylation pathways in several organisms and tissues. The present review consists of an actualization of basic research on phospholipid and phosphoinositide phosphorylation and hydrolysis pathways, as well as a description of some reported evidences for the effects of the above mentioned pesticides on them.

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Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Convergences and divergences among eukaryotic kingdoms

Cited by 85 publications

References 205 publications

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

Molecular mechanisms of gravity perception and signal transduction in plants

Phosphoinositide and phospholipid phosphorylation and hydrolysis pathways<br/>—Organophosphate and organochlorine pesticides effects<br>

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Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Convergences and divergences among eukaryotic kingdoms

Cited by 85 publications

References 205 publications

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity

Molecular mechanisms of gravity perception and signal transduction in plants

Phosphoinositide and phospholipid phosphorylation and hydrolysis pathways&lt;br/&gt;—Organophosphate and organochlorine pesticides effects&lt;br&gt;

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Phosphoinositide and phospholipid phosphorylation and hydrolysis pathways<br/>—Organophosphate and organochlorine pesticides effects<br>