Signal transduction of<i>Helicobacter pylori</i>during interaction with host cell protein receptors of epithelial and immune cells

Pachathundikandi, Suneesh Kumar; Tegtmeyer, Nicole; Backert, Steffen

doi:10.4161/gmic.27001

Cited by 69 publications

(49 citation statements)

References 150 publications

(264 reference statements)

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“…One such example is CagL of Helicobacter pylori that binds to β1 integrin followed by injection of CagA effector protein (Kwok et al, ). CagL was also observed to activate FAK and Src, thus leading to F‐actin modulation (Pachathundikandi, Tegtmeyer, & Backert, ; Tegtmeyer et al, ). However, our preliminary study suggested that OmpV may not serve as receptor for type 3 secretion needle (data not shown), but OmpV‐mediated activation of α1β1 integrin leads to intracellular FAK phosphorylation and F‐actin modulation (Figure ).…”

Section: Discussionmentioning

confidence: 99%

Outer membrane protein OmpV mediatesSalmonella entericaserovar typhimurium adhesion to intestinal epithelial cells via fibronectin and α1β1 integrin

Kaur

Mukhopadhaya

2020

Cellular Microbiology

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Salmonella typhimurium is an invasive Gram‐negative enteric bacterium, which causes salmonellosis, a type of gastroenteritis in humans and typhoid‐like symptoms in mice. Upon entering through the contaminated food and water, S. typhimurium adheres, colonises, and invades intestinal epithelial cells (IECs) of the small intestine. In this study, we have shown that upon deletion of the outer membrane protein OmpV, there is a significant decrease in adherence of S. typhimurium to the IECs, indicating that OmpV is an important adhesin of S. typhimurium. Further, our study showed that OmpV binds to the extracellular matrix component fibronectin and signals through α1β1 integrin receptor on the IECs and OmpV‐mediated activation of α1β1, resulting in the activation of focal adhesion kinase and F‐actin modulation. Actin modulation is crucial for bacterial invasion. To the best of our knowledge, this is the first report of an adhesin mediated its effect through integrin in S. typhimurium. Further, we have observed a decrease in pathogenicity in terms of increased LD50 dose, lesser bacterial numbers in stool, and less colonisation of bacteria in different organs of mice infected with Δompv mutant compared with the wild‐type bacteria, thus confirming the crucial role of OmpV in the pathogenesis of S. typhimurium.

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Section: Discussionmentioning

confidence: 99%

Outer membrane protein OmpV mediatesSalmonella entericaserovar typhimurium adhesion to intestinal epithelial cells via fibronectin and α1β1 integrin

Kaur

Mukhopadhaya

2020

Cellular Microbiology

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“…Similar to BabA, the SabA has affinity for sialyl-Le x [43]. Toll-like receptor 4 (TLR4) is a known receptor for bacterial LPS [44]. The LabA adhesin specifically binds to GalNAcβ1-4GlcNAc motif, also known as N,N′-diacetyllactosediamine [lacdiNAc]), carried by MUC5AC mucins [45, 46].…”

Section: Opisthorchis Is a Reservoir Of H Pylori And Host-bacterimentioning

confidence: 99%

Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma?

Sripa

Deenonpoe

Brindley

2017

Parasitology International

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Infection with the fish-borne liver fluke Opisthorchis viverrini is classified by the International Agency for Research on Cancer as a Group 1 carcinogen: definitely carcinogenic in humans. Cofactors likely contribute to bile duct cancer (cholangiocarcinoma) caused by this infection. Here we review recent findings that address the role of liver fluke associated H. pylori in hepatobiliary disease and malignancy. We hypothesize that co-infection by O. viverrini and the bacillus Helicobacter pylori is central of liver fluke infection associated cholangiocarcinoma.

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“…The other most studied H. pylori virulence factor is VacA (vacuolating cytotoxin A) which induces cytoplasmic vacuolation by forming membrane channels in epithelial membranes in vitro (Cover and Blaser, 1992). Besides this activity, it has a multifunctional role in colonization, virulence and immunomodulation (Cover and Blanke, 2005;Pachathundikandi et al, 2013). Apart from these two cardinal effectors, virulence genes such as BabA, SabA, SabB, OipA etc.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase

Tenguria

Ansari

Khan

et al. 2014

International Journal of Medical Microbiology

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Signal transduction ofHelicobacter pyloriduring interaction with host cell protein receptors of epithelial and immune cells

Cited by 69 publications

References 150 publications

Outer membrane protein OmpV mediatesSalmonella entericaserovar typhimurium adhesion to intestinal epithelial cells via fibronectin and α1β1 integrin

Outer membrane protein OmpV mediatesSalmonella entericaserovar typhimurium adhesion to intestinal epithelial cells via fibronectin and α1β1 integrin

Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma?

Helicobacter pylori cell translocating kinase (CtkA/JHP0940) is pro-apoptotic in mouse macrophages and acts as auto-phosphorylating tyrosine kinase

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