“…Potentially, PolyP can play multiple roles in the CNS (Kumble and Kornberg, 1995;Angelova et al, 2016;Cremers et al, 2016;Müller et al, 2017). For example, in astrocytes it is localized in mitochondria, lysosomes, and vesicular nucleotide transporter (VNUT)-containing vesicles (Abramov et al, 2007;Pavlov et al, 2010;Holmström et al, 2013;Angelova et al, 2018). PolyP is released from lysosomes or VNUT vesicles by exocytosis, which leads to the development of calcium waves Angelova et al, 2018).…”