Signal transduction from small particles: Sulfur nanodots featuring mercury sensing, cell entry mechanism and in vitro tracking performance

Qiao, Gongxi; Liu, Lei; Hao, Xiaoxing; Zheng, Junke; Liu, Wanqiang; Gao, Jinwei; Zhang, Cheng Cheng; Wang, Qianming

doi:10.1016/j.cej.2019.122907

Cited by 119 publications

(98 citation statements)

References 36 publications

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“…Transmission electron microscope (TEM) images show that spherical SQDs with diameter in range of 1.5-5 nm display lattice fringe of about 0.216 nm (Figure 2a-c), which is analogous to the reported SQDs. [4,7] The characteristic peaks in the Raman spectrum of SQDs are almost the same as those of sublimated sulfur (Figure 2d), indicating that the formed particles are SQDs. The X-ray photoelectron spectroscopy (XPS) survey spectrum of SQDs shows obvious C, O, and S peaks (Figure S1, Supporting Information).…”

Section: Synthesis and Characterization Of Pva-capped Sqdsmentioning

confidence: 77%

“…The UV-vis absorption spectrum of SQDs displays an obvious absorption band centered at about 254 nm (Figure 3a), which is assigned to the n-π* transition of sulfur atom. Like other reported SQDs, [3][4][5][6][7][8][9] the emission of these PVA-capped SQDs could also be easily tuned by adjusting the excitation wavelength (λ ex ). When varying the λ ex from 300 to 420 nm, the associated fluorescence peak changed from 432 to 501 nm (Figure 3b).…”

Section: Optical Propertiesmentioning

confidence: 91%

“…[2] The applications of SQDs in cellular imaging, light emitting diode, photocatalysis, polymer nanocomposite, and as well as fluorescence detection have been widely studied in the past two years. [3][4][5][6][7][8][9][10][11][12] Until now, numerous methods have been developed for synthesizing SQDs and most of them employed polyethylene glycol (PEG) as ligand to stabilize SQDs based on the affinity interaction between the hydroxyl group of PEG and the SQDs surface. [3][4][5][6][7][8][9] As each PEG macromolecule can provide only one hydroxyl group to bind with SQD, the PEG ligand the hydroxyl groups of PVA and Fe 3+ , and this complex interaction has been widely used to prepare magnetic PVA-based nanocomposite.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe³⁺ and Temperature in Cells

Lei

Huang

Gao

et al. 2021

Part & Part Syst Charact

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cannot endow the SQD with enough stability. The prepared SQDs generally exhibit poor optical stability, limiting their down-to-earth applicability. For example, the fluorescent intensity of PEG-capped SQDs declined by 48% after exposure to UV lamp for 10 min. [4] In this context, it is very important and urgent to develop a simple and effective approach to enhance the optical stability of SQDs.As a kind of essential trace ion in organism, Fe 3+ plays an important role in numerous metabolic processes, such as enzyme catalysis, oxygen exchange, and transport. [13] Excessive or deficiency of Fe 3+ may result in a series of diseases (e.g., heart failure and anemia), and thus monitoring of Fe 3+ is quite meaningful for early clinical diagnosis. [14] On the other hand, temperature is a critical physical parameter that can affect the behavior of chemical and biological systems. Hence, the development of temperature sensor to monitor temperature in diverse environments especially in biosystem is highly needed. Among various technologies for monitoring of Fe 3+ or temperature, much attention has been paid on fluorescence detection because of its advantages of facile sample treatment process, superior sensitivity, rapid response, noninvasiveness, and low cost. [15,16] In recent years, a variety of fluorescent materials such as semiconductor quantum dots, silicon nanocrystals, metal nanoclusters, organic dyes, conjugated polymers, and carbon dots have been developed to detect Fe 3+ or temperature. [17][18][19][20][21][22][23][24] Unfortunately, most of them are either toxic or suffer from poor stability and high cost, which seriously hinders their practical applications. In addition, many fluorescent materials exhibit poor aqueous solubility or dispersibility, so their ability to detect Fe 3+ or temperature in biological environment (e.g., cells) is greatly limited. Therefore, the rational design and preparation of desired fluorescent probes to detect Fe 3+ or temperature in biological environment remain a challenge and is valuable.In this contribution, we attempt to utilize water-soluble and biocompatible polyvinyl alcohol (PVA) as ligand for fabricating fluorescent SQDs (Figure 1). PVA was carefully chosen because each PVA macromolecule contains a number of lateral hydroxyl groups, which can provide strong affinity interaction with the surface of formed SQDs to enhance the stability of SQDs. On the other hand, there is a strong complex interaction between As a new class of metal-free fluorescent dots, sulfur quantum dots (SQDs) have attracted more and more attention because of their unique properties and promising applications in many fields. However, synthesizing SQDs with high optical stability and stimuli-responsive fluorescence is still in its infancy. Herein, a simple one-pot strategy is reported for preparing polyvinyl alcohol (PVA)-capped SQDs from cheap elemental sulfur by employing PVA as ligand. The as-prepared SQDs with size in range of 1.5-5 nm show fine water dispersibility and stability, bright fluorescence,...

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Section: Synthesis and Characterization Of Pva-capped Sqdsmentioning

confidence: 77%

Section: Optical Propertiesmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe³⁺ and Temperature in Cells

Lei

Huang

Gao

et al. 2021

Part & Part Syst Charact

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show abstract

“…As emerging quantum dots, sulfur quantum dots have been paid much attention due to their possessions of inexpensive S atoms and unique physicochemical properties [ 82 , 83 , 84 ]. Literature has demonstrated that sulfur quantum dots were applied in the field of sensor [ 81 , 85 , 124 ]. For example, sulfur quantum dots have been used for sensing metal ions or detecting drug [ 81 , 125 ].…”

Section: Sulfur-containing Quantum Dotsmentioning

confidence: 99%

“…For example, sulfur quantum dots have been used for sensing metal ions or detecting drug [ 81 , 125 ]. Very recently, sulfur quantum dots also have gradually been applied to living cells imaging [ 124 ]. However, applications of sulfur quantum dots in biosensing or bio-medical diagnosis field were still far from satisfactory.…”

Section: Sulfur-containing Quantum Dotsmentioning

confidence: 99%

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Wang

Jiang

et al. 2020

Sensors

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In recent years, sulfur-containing nanomaterials and their derivatives/composites have attracted much attention because of their important role in the field of biosensor, biolabeling, drug delivery and diagnostic imaging technology, which inspires us to compile this review. To focus on the relationships between advanced biomaterials and biosensors, this review describes the applications of various types of sulfur-containing nanomaterials in biosensors. We bring two types of sulfur-containing nanomaterials including metallic sulfide nanomaterials and sulfur-containing quantum dots, to discuss and summarize the possibility and application as biosensors based on the sulfur-containing nanomaterials. Finally, future perspective and challenges of biosensors based on sulfur-containing nanomaterials are briefly rendered.

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Two‐Step Oxidation Synthesis of Sulfur with a Red Aggregation‐Induced Emission

et al. 2020

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Sulfur is not normally considered a light‐emitting material, even though there have been reports of a dim luminescence of this compound in the blue‐to‐green spectral region. Now, it is shown how to make red‐emissive sulfur by a two‐step oxidation approach using elemental sulfur and Na2S as starting materials, with a high photoluminescence quantum yield of 7.2 %. Polysulfide is formed first and is partially transformed into Na2S2O3 in the first step, and then turns back to elemental S in the second step. The elevated temperature and relatively oxygen‐deficient environment during the second step transforms Na2S2O3 into Na2SO3 incorporated with oxygen vacancies, thus resulting in the formation of a solid‐state powder consisting of elemental S embedded in Na2SO3. It shows aggregation‐induced emission properties, attributed to the influence of oxygen vacancies on the emission dynamics of sulfur by providing additional lower energy states that facilitate the radiative relaxation of excitons.

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Signal transduction from small particles: Sulfur nanodots featuring mercury sensing, cell entry mechanism and in vitro tracking performance

Cited by 119 publications

References 36 publications

Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe³⁺ and Temperature in Cells

Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe³⁺ and Temperature in Cells

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Two‐Step Oxidation Synthesis of Sulfur with a Red Aggregation‐Induced Emission

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Signal transduction from small particles: Sulfur nanodots featuring mercury sensing, cell entry mechanism and in vitro tracking performance

Cited by 119 publications

References 36 publications

Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe3+ and Temperature in Cells

Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe3+ and Temperature in Cells

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Two‐Step Oxidation Synthesis of Sulfur with a Red Aggregation‐Induced Emission

Contact Info

Product

Resources

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Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe³⁺ and Temperature in Cells

Polyvinyl Alcohol Enhanced Fluorescent Sulfur Quantum Dots for Highly Sensitive Detection of Fe³⁺ and Temperature in Cells