Signal Transduction by Receptors for BAFF and APRIL

Hildebrand, Joanne M.; Xie, Ping; Bishop, Gail A.

doi:10.1007/978-1-60327-013-7_5

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Regulation Of Mature B Cell Survival1

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2014

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Cited by 2 publications

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“…TNFSF13B‐mediated B‐cell survival is regulated by at least five pathways that result in attenuation of apoptosis: (i) activation of classical and alternative NF‐κB; (ii) activation of the anti‐apoptotic proteins, Mcl‐1 and Pim2; (iii) down‐regulation of the pro‐apoptotic protein, Bim; (iv) nuclear exclusion of PKCδ; and (v) PKCβ‐dependent activation of Akt (Claudio et al ., ; Woodland et al ., ; Hildebrand et al ., ; Khan et al ., ).…”

Section: Regulation Of Mature B Cell Survivalmentioning

confidence: 99%

Midkine as a regulator of B cell survival in health and disease

Cohen

Shachar

2014

British J Pharmacology

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In healthy individuals, the pool of peripheral lymphocytes is constant in size. The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, survival and proliferation. Survival factors have been shown to play a critical role in maintaining the correct size of lymphocyte populations. Midkine, a heparin-binding cytokine was recently shown to be involved in cell proliferation, differentiation and apoptosis in various cell types including normal and malignant B cells. This review focuses on the role of midkine in the regulation of peripheral B cell survival in health and disease. LINKED ARTICLESThis article is part of a themed section on Midkine. To view the other articles in this section visit http://dx

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Section: Regulation Of Mature B Cell Survivalmentioning

confidence: 99%