Signal Processing of Underwater Acoustic Waves

Horton, C. W.

doi:10.21236/ada951635

Cited by 47 publications

(10 citation statements)

References 28 publications

(46 reference statements)

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“…Certain fatty acids that are not precursors to prostaglandins have been shown to inhibit their biosynthesis (Pace-Asciak and Wolfe, 1968 ;Nugteren, 1970). Prostaglandins are widespread in occurrence in mammalian tissues and possess diverse physiological activ- ities Ramwell et al, 1968;Horton, 1969). Recently two new prostaglandin derivatives were isolated from marine invertebrates (Weinheimer and Spraggins, 1969).…”

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confidence: 99%

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

Pace-Asciak¹,

Wolfe²

1971

Biochemistry

160

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pseudouridine was prepared using the ribonuclease-catalyzed reaction described by Heppel et al. (1955). Cytidine 2',3'cyclic phosphate (0.1 mmole) and pseudouridine (100 mg) were dissolved in 0.015 M Tris-chloride buffer (pH 7; 5 ml) and treated with pancreatic ribonuclease (0.1 mg) at 37" for 75 min. The mixture was then shaken with isoamyl alcohol (0.6 ml) and chloroform (0.15 ml) and streaked on Whatman No. 3MM chromatographic paper (66 cm). The components of the mixture were separated with solvent system B and the dinucleoside phosphate band was cut out and eluted (yield, 30 ODU). This product was found to be completely degradable by ribonuclease to cytidine 3'-phosphate and pseudouridine. The dinucleoside phosphate (20 ODU) was dissolved in 0.05 M sodium borate buffer (pH 8.5 ; 0.3 ml) and treated with Cmcp-toluenesulfonate (40 mg). The mixture was allowed to stand for 20 hr. At this time paper chromatography in solvent systems A and B showed that about 70% of the material had been converted to Cmc derivatives. The dinucleoside phosphate and its mono-Cmc derivative had RF values 0.41 and 0.61 (solvent system A); 0.18 and 0.26 (solvent system B), respectively. The mixture was treated with concentrated ammonia for 2 hr and then applied to Whatman No. 3MM chromatographic paper and then separated in solvent system B. The Cmc-dinucleoside phosphate (6 ODU) was dissolved in 0.02 M sodium phosphate buffer (pH 7.0; 0.2 ml) and treated with pancreatic ribonuclease (2.5 pg) at 37" for 4 hr. Paper chromatography in solvent system A showed that about 70% of the Cmc derivative had been converted into a mixture of cytidine 3'-phosphate and Cmc-pseudouridine. With twice the amount of enzyme under the same conditions it was possible to hydrolyze all the dinucleoside phosphate to its components.

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confidence: 99%

Novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates

Pace-Asciak¹,

Wolfe²

1971

Biochemistry

160

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“…Microelectrophoretic administration of the prosta-I glandins E1 and E2, thought to inhibit adenyl cyclase activity (14), reduces the slowing of spontaneous discharge obtained by application of NE from another barrel of the same micropipette. Our studies of ultrastructure show nerve terminals in the cerebellar cortex containing large granular vesicles, characteristic of the nerve endings in the brain, which contain monoamine (15).…”

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confidence: 99%

Cyclic Adenosine Monophosphate: Possible Mediator for Norepinephrine Effects on Cerebellar Purkinje Cells

Siggins

Hoffer

Bloom

1969

Science

190

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Microelectrophoretic application of norepinephrine or cyclic adenosine monophosphate reduces the discharge frequency of Purkinje cells in the rat cerebellum. In contrast, other nucleotides accelerate the discharge rate of most units. Parenterally administered theophylline, which inhibits the hydrolysis of cyclic adenosine monophosphate enhances the effects of norepinephrine and cyclic adenosine monophosphate. Therefore, norepinephrine may be able to regulate Purkinje cells functionally by metabolic stimulation of cyclic adenosine monophosphate synthesis.

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“…It is known with some certainty, however, that prostaglandins have an intimate relationship with catecholamines and the adrenergic system, adenyl cyclase and cyclic AMP, and that they play a hormonal role in some processes such as reproduction. 3 In a series of studies4'5 culminating in some theoretical considerations of a-and /3-adrenergic activity,6 we invoked a possible structural relationship between /3-adrenergic agents and prostaglandin Ed to support our hypothesis of structure-activity relationships influencing /3-adrenergic activity. We noted that if prostaglandin Ei was assigned a "reasonable" conformation in regard to the hydroxylated side chain, then a definite similarity of functional group positions with TV-n-propylnorepinephrine, in its calculated preferred conformation, was evident.…”

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confidence: 76%