Signal processing &amp; audio processors

Dhanasingh, Anandhan; Hochmair, Ingeborg

doi:10.1080/00016489.2021.1888504

Cited by 16 publications

(12 citation statements)

References 47 publications

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“…A stimulation that provides a lower amplitude and a lower most comfortable level, as in biphasic pulse stimulation, is the triphasic stimulation used by another manufacturer. 13 This can prevent an AFNS if high electric charges are needed for the patient, but in our case, the electric charge that affected the facial nerve was very low (under 5,5 nano coulomb (nC)) with the HiRes TM Ultra device, and we therefore expected no improvement of the AFNS with this stimulation mode. The Neuro Zti implant uses an asymmetric stimulation method.…”

Section: Discussionmentioning

confidence: 69%

Multi‐mode grounding and monophasic passive discharge stimulation avoid aberrant facial nerve stimulation following cochlear implantation

Zellhuber

Helbig

James

et al. 2022

Clinical Case Reports

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Section: Discussionmentioning

confidence: 69%

Multi‐mode grounding and monophasic passive discharge stimulation avoid aberrant facial nerve stimulation following cochlear implantation

Zellhuber

Helbig

James

et al. 2022

Clinical Case Reports

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“…Another major development has been the totally implantable cochlear implant (TICI; Mi2000, ClinicalTrials.gov Identifier: NCT04571333). In terms of improving the transmission of time and frequency information, there have been recent advancements in temporal fine structure coding for electrodes that carry low-frequency information (Dhanasingh & Hochmair, 2021) and multipolar stimulation for improved frequency selectivity (Bierer, 2010). In this review, we will focus on three recent developments that combine advances in medical device engineering with biotechnology to genetically modify target cells: improvement of the electrodeneural interface, using light for the stimulation of the auditory nerve, and hybrid optical-electrical stimulation.…”

Section: Innovations Of Cochlear Implantsmentioning

confidence: 99%

“…Another major development has been the totally implantable cochlear implant (TICI; Mi2000, http://clinicaltrials.gov Identifier: NCT04571333). In terms of improving the transmission of time and frequency information, there have been recent advancements in temporal fine structure coding for electrodes that carry low‐frequency information (Dhanasingh & Hochmair, 2021) and multipolar stimulation for improved frequency selectivity (Bierer, 2010).…”

Section: Introduction—hearing Hearing Impairment and Hearing Restorationmentioning

confidence: 99%

Is there an unmet medical need for improved hearing restoration?

et al. 2022

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Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for the most common form, sensorineural hearing impairment; hearing aids and cochlear implants (CI) remain the only means of hearing restoration. We engaged with CI users to learn about their expectations and their willingness to collaborate with health care professionals on establishing novel therapies. We summarize upcoming CI innovations, gene therapies, and regenerative approaches and evaluate the chances for clinical translation of these novel strategies. We conclude that there remains an unmet medical need for improving hearing restoration and that we are likely to witness the clinical translation of gene therapy and major CI innovations within this decade.

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“…Participants listened with default filter frequencies of 100-8,500 Hz and the FS4 coding strategy, which provides fine structure cues on the 4 most apical channels. Fine structure cues are presented via bursts of high-stimulation rate; the input frequency for each channel controls the timing of the bursts [see Dhanasingh and Hochmair, 2021]. The clinical trial CI mapping procedures included behavioral measurement of electric threshold and maximum comfort levels, as well as loudness balancing across channels and between the CI and NH-ear [Dillon et al, 2019].…”

Section: Listenersmentioning

confidence: 99%

“…Three listeners (Listeners 1, 12, and 15) presented with aidable hearing sensitivity (i.e., ≤80 dB HL) at 125 Hz in the implanted ear. All listeners continued to use the FS4 coding strategy after completion of the clinical trial, with the exception of Listener 3 who changed from the FS4 coding strategy to the FS4-p coding strategy at the 1-year visit; whereas FS4 uses sequential stimulation, FS4-p uses simultaneous stimulation for instances when the fine structure cues overlap in time [see Dhanasingh and Hochmair, 2021]. The filter frequencies of 100-8,500 Hz were maintained for the maps used by all listeners.…”

Section: Sound Source Localization At the 2-year Post-activation Visitmentioning

confidence: 99%

Sound Source Localization by Cochlear Implant Recipients with Normal Hearing in the Contralateral Ear: Effects of Spectral Content and Duration of Listening Experience

et al. 2022

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Introduction: Cochlear implant (CI) recipients with normal hearing (NH) in the contralateral ear experience a significant improvement in sound source localization when listening with the CI in combination with their NH-ear (CI + NH) as compared to with the NH-ear alone. The improvement in localization is primarily due to sensitivity to interaural level differences (ILDs). Sensitivity to interaural timing differences (ITDs) may be limited by auditory aging, frequency-to-place mismatches, the signal coding strategy, and duration of CI use. The present report assessed the sensitivity of ILD and ITD cues in CI + NH listeners who were recipients of long electrode arrays that provide minimal frequency-to-place mismatches and were mapped with a coding strategy that presents fine structure cues on apical channels. Methods: Sensitivity to ILDs and ITDs for localization was assessed using broadband noise (BBN), as well as high-pass (HP) and low-pass (LP) filtered noise for adult CI + NH listeners. Stimuli were 200-ms noise bursts presented from 11 speakers spaced evenly over an 180° arc. Performance was quantified in root-mean-squared error and response patterns were analyzed to evaluate the consistency, accuracy, and side bias of the responses. Fifteen listeners completed the task at the 2-year post-activation visit; seven listeners repeated the task at a later annual visit. Results: Performance at the 2-year visit was best with the BBN and HP stimuli and poorer with the LP stimulus. Responses to the BBN and HP stimuli were significantly correlated, consistent with the idea that CI + NH listeners primarily use ILD cues for localization. For the LP stimulus, some listeners responded consistently and accurately and with limited side bias, which may indicate sensitivity to ITD cues. Two of the 7 listeners who repeated the task at a later annual visit experienced a significant improvement in performance with the LP stimulus, which may indicate that sensitivity to ITD cues may improve with long-term CI use. Conclusions: CI recipients with a NH-ear primarily use ILD cues for sound source localization, though some may use ITD cues as well. Sensitivity to ITD cues may improve with long-term CI listening experience.

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Signal processing & audio processors

Cited by 16 publications

References 47 publications

Multi‐mode grounding and monophasic passive discharge stimulation avoid aberrant facial nerve stimulation following cochlear implantation

Multi‐mode grounding and monophasic passive discharge stimulation avoid aberrant facial nerve stimulation following cochlear implantation

Is there an unmet medical need for improved hearing restoration?

Sound Source Localization by Cochlear Implant Recipients with Normal Hearing in the Contralateral Ear: Effects of Spectral Content and Duration of Listening Experience

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