Signal pathways involved in the biological effects of sulfur dioxide

Wang, Xinbao; Du, Junbao; Cui, Hong

doi:10.1016/j.ejphar.2015.06.044

Cited by 41 publications

(21 citation statements)

References 48 publications

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“…Although no single dependent variable achieved statistical significance, the consistency of the trend raises the possibility of some other protective factor(s) in this community or a direct salutary effect of this blend of SO 2 and acid particulates (53). Longitudinal follow up can determine if the trends persist, and discern protective factors, if any.…”

Section: Discussionmentioning

confidence: 89%

Volcanic air pollution over the Island of Hawai'i: Emissions, dispersal, and composition. Association with respiratory symptoms and lung function in Hawai'i Island school children

Tam

Miike

Labrenz

et al. 2016

Environment International

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Section: Discussionmentioning

confidence: 89%

Volcanic air pollution over the Island of Hawai'i: Emissions, dispersal, and composition. Association with respiratory symptoms and lung function in Hawai'i Island school children

Tam

Miike

Labrenz

et al. 2016

Environment International

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“…The high dose of SO 2 has toxic effects including oxidative damage, deoxyribonucleic damage and induced inflammatory cytokines (Li et al, ; Qin & Meng, ; Sang, Hou, Yun, & Li, ). However, there is evidence that SO 2 also can be an important physiological gasotransmitter in mammals (Wang, Du, & Cui, ). SO 2 may be an endothelium‐derived relaxing factor in cardiovascular tissues in mammals (Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…However, there is evidence that SO 2 also can be an important physiological gasotransmitter in mammals (Wang, Du, & Cui, ). SO 2 may be an endothelium‐derived relaxing factor in cardiovascular tissues in mammals (Wang et al, ). It was found that SO 2 could increase NO production in SHR and Wistar rats (Li et al, ; Lu et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Effect of low androgen levels on the sulphur dioxide signalling pathway in rat penile corpus cavernosum

Jiang²,

Xia

et al. 2018

Andrologia

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| INTRODUC TI ONErectile dysfunction (ED) is one of the most common sexual dysfunctions in men. Epidemiological study has demonstrated that the incidence rate of ED is about 42% in men aged 40-70 years in New Zealand, and it increases with age ( AbstractThe aim of this study was to investigate the relationship between sulphur dioxide (SO 2 ) signalling pathway and the changes in erectile function under low androgen levels.Thirty-six healthy male Sprague Dawley (SD) rats aged eight weeks were randomly divided into androgen replacement group, castration group and sham group. Rats in the androgen replacement group were subcutaneously injected with testosterone propionate at 3 mg/kg every other day postcastration. The maximum intracavernous pressure/ mean arterial pressure (ICP max /MAP) and the relative content of SO 2 in the penile corpus cavernosum were measured. The mRNA and protein expressions of aspartate aminotransferase (AAT1 and AAT2), cysteine oxidase (CDO), endothelial nitric oxide synthase (eNOS) and phosphorylation of endothelial nitric oxide synthase (P-eNOS) were detected. ICP max /MAP, P-eNOS/eNOS and the level of SO 2 decreased significantly in the castration group compared to the other groups (p < 0.05). The expressions of mRNA and protein decreased significantly in the castration group compared to the androgen replacement group and the sham group (p < 0.05), while there was no significant difference between the androgen replacement group and sham group. Low androgen levels can inhibit erectile function by downregulating the SO 2 signalling pathway.

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“…Zhang et al (44) found that SO 2 and its derivatives could activate the K ATP and BK Ca channels by upregulating the protein expressions of Kir6.1, Kir6.2, SUR2B, and BK Ca channel subunits ␣ and ␤ 1 , but inhibit the L-Ca 2ϩ channel by downregulating the protein expression levels of Cav1.2 and Cav1.3. Thus, ion channels, such as L-Ca 2ϩ , K ATP , and BK Ca channels, as well as cGMP and cAMP pathways play important roles in the effects of SO 2 on vasodilation (37). The increase in cGMP concentration through sGC activation can stimulate a myriad of downstream intracellular effectors, such as cGMP-and/or cAMP-dependent protein kinases, protein kinase-independent pathways, or hydrolyzing cGMP-specific PDEs, thereby activating cAMP pathway and modulating ion channels, such as L-Ca 2ϩ , K ATP , and BK Ca channels (34).…”

Section: Discussionmentioning

confidence: 99%

The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization

Yao

Huang

Liu

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization. Am J Physiol Regul Integr Comp Physiol 310: R1073-R1080, 2016. First published March 23, 2016 doi:10.1152/ajpregu.00101.2015.-The present study was designed to explore the role of soluble guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/PKG pathway in sulfur dioxide (SO 2)-induced vasodilation. We showed that SO2 induced a concentration-dependent relaxation of phenylephrine (PE)-precontracted rat aortic rings in association with an increase in cGMP concentration, whereas L-aspartic acid ␤-hydroxamate (HDX), an inhibitor of SO 2 synthase, contracted rings in a dose-dependent manner. Pretreatment of aortic rings with the sGC inhibitor ODQ (30 M) attenuated the vasodilatory effects of SO 2, suggesting the involvement of cGMP pathway in SO 2-induced vasodilation. Mechanistically, SO 2 upregulated the protein levels of sGC and PKG dimers, while HDX inhibited it, indicating SO 2 could promote cGMP synthesis through sGC activation. Furthermore, the dimerization of sGC and PKG and vasodilation induced by SO 2 in precontracted rings were significantly prevented by thiol reductants dithiothreitol (DTT). In addition, SO 2 reduced the activity of phosphodiesterase type 5 (PDE5), a cGMP-specific hydrolytic enzyme, implying that SO 2 elevated cGMP concentration by inhibiting its hydrolysis. Hence, SO2 exerted its vasodilatory effects at least partly by promoting disulfidedependent dimerization of sGC and PKG, resulting in an activated sGC/cGMP/PKG pathway in blood vessels. These findings revealed a new mode of action and mechanisms by which SO 2 regulated the vascular tone. sulfur dioxide; vasodilation; SGC; cGMP; PKG; dimer IN THE LAST DECADE, RESEARCH focusing on sulfur-containing amino acid metabolic pathways indicates that L-cysteine as a substrate cannot only generate hydrogen sulfide (H 2 S) through transsulfuration under cystathionine-␥-lyase or cystathionine-␥-synthase catalysis (35), but also endogenously generate sulfur dioxide (SO 2 ) under cysteine dioxygenase oxidation and aspartate aminotransferase (AAT) transamination (32). Recent studies have shown that endogenous SO 2 is generated in cardiovascular tissues, such as vascular endothelium, medial smooth muscles, right ventricle, and left ventricle (8). Similar to H 2 S, endogenous SO 2 has important physiological and pathophysiological roles, including hypotensive activity (4, 18), vasodilation (8, 9), inhibition of oxidative stress (3,28,48), inhibition of smooth muscle cell proliferation (17), and remodeling of pulmonary arterial endothelial cells (33), protection against myocardial ischemia/reperfusion (14,45,46), and isopropylarterenol-induced apoptosis (16). An increasing number of studies suggest that endogenous SO 2 is also a gaseous signaling molecule with a variety of cardiovascular functions, including vasodilation (24,44,26). Previous studies have shown that SO 2 could activate the calcium and potassium channels by i...

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Signal pathways involved in the biological effects of sulfur dioxide

Cited by 41 publications

References 48 publications

Volcanic air pollution over the Island of Hawai'i: Emissions, dispersal, and composition. Association with respiratory symptoms and lung function in Hawai'i Island school children

Volcanic air pollution over the Island of Hawai'i: Emissions, dispersal, and composition. Association with respiratory symptoms and lung function in Hawai'i Island school children

Effect of low androgen levels on the sulphur dioxide signalling pathway in rat penile corpus cavernosum

The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization

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