Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO<sub>2</sub> nanobelts for insulin detection

Du, Yu; Li, Xiaojian; Ren, Xiang; Wang, Huan; Wu, Dan; Ma, Hongmin; Fan, Dawei; Wei, Qin

doi:10.1039/c9an02288k

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…According to Du et al, CdS@TiO 2 emits a highly transcendent ECL, whereas curcumin-Au NPs incorporated in ZIF-8 led to an intense reduction in ECL from CdS@ TiO 2 . ECL-RET acceptors have also been developed from Ag nanoclusters (Ag NCs [47].…”

Section: Metal-organic Frameworkmentioning

confidence: 99%

Recent Advances in Quantum Dots-Based Biosensors

Safari¹

2023

Quantum Dots - Recent Advances, New Perspectives and Contemporary Applications

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Biosensors can be developed using quantum dots (QDs). An inorganic nucleus with organic molecules attached to its surface is referred to as a QD, and they are a type of new fluorescent nanomaterial. QDs possess unique excellent optical properties and chemical properties, including broad excitation spectra, adjustable particle sizes, confined emission spectra, emission of multiple fluorescence colors, superior signal brightness, and extended fluorescence lifetime. QDs have abundant functional groups, which make it easy to form hybrid nanomaterials that perform analytically well. With functionalized sensing systems, we can detect metal ions, biomarkers, and antibiotics sensitively and selectively through the hybridization of QDs with nanomaterials. In this chapter, we first introduce the research trends in the application of QDs and then discuss their surface modification for biological applications.

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Section: Metal-organic Frameworkmentioning

confidence: 99%

Recent Advances in Quantum Dots-Based Biosensors

Safari¹

2023

Quantum Dots - Recent Advances, New Perspectives and Contemporary Applications

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“…The prepared sensor could achieve highly sensitive and accurate MTX determination with excellent results [ 96 ]. At the same time, ECL signaling was enhanced through SO 4 − ·, which acted as a folic acid (FA) sensor [ 97 ] and was applied for insulin detection [ 98 ], showing its potential for biosensing medicine.…”

Section: Metal-based Nanomaterialsmentioning

confidence: 99%

State-of-the-Art on the Sulfate Radical-Advanced Oxidation Coupled with Nanomaterials: Biological and Environmental Applications

Yang

et al. 2022

JFB

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Sulfate radicals (SO4−) play important biological roles in biomedical and environmental engineering, such as antimicrobial, antitumor, and disinfection. Compared with other common free radicals, it has the advantages of a longer half-life and higher oxidation potential, which could bring unexpected effects. These properties have prompted researchers to make great contributions to biology and environmental engineering by exploiting their properties. Peroxymonosulfate (PMS) and peroxydisulfate (PDS) are the main raw materials for SO4− formation. Due to the remarkable progress in nanotechnology, a large number of nanomaterials have been explored that can efficiently activate PMS/PDS, which have been used to generate SO4−·for biological applications. Based on the superior properties and application potential of SO4−, it is of great significance to review its chemical mechanism, biological effect, and application field. Therefore, in this review, we summarize the latest design of nanomaterials that can effectually activate PMS/PDS to create SO4−, including metal-based nanomaterials, metal-free nanomaterials, and nanocomposites. Furthermore, we discuss the underlying mechanism of the activation of PMS/PDS using these nanomaterials and the application of SO4− in the fields of environmental remediation and biomedicine, liberating the application potential of SO4−. Finally, this review provides the existing problems and prospects of nanomaterials being used to generate SO4−· in the future, providing new ideas and possibilities for the development of biomedicine and environmental remediation.

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“…As a promising semiconductor, TiO 2 has been widely used due to its good catalytic activity, good biocompatibility, low cost, and chemical stability. , Scientific researchers in the field of ECL noticed the excellent physical and chemical properties of TiO 2 . TiO 2 has the ability to catalyze the conversion of H 2 O 2 and dissolved O 2 into ROS by utilizing its oxygen vacancy. , Recently, TiO 2 composites with excellent properties have attracted much attention, such as CdS@TiO 2 , Cu-doped TiO 2 , Au/TiO 2 , AuAg/TiO 2 , and attapulgite–TiO 2 . − Thus, it would be meaningful to find the excellent properties of TiO 2 composite material. As an emerging two-dimensional metal carbide, Ti 3 C 2 MXene has attracted attention since its discovery due to its good electrical conductivity, unique reducibility, stability, and large specific surface area. − Our group took the lead in applying Ti 3 C 2 to the ECL biosensing system and carried out a series of studies on its properties. − Inspired by the abovementioned work, we intend to use the reducibility and rich Ti sources on the surface of Ti 3 C 2 to prepare a Ti 3 C 2 –TiO 2 composite in situ, which could prevent the self-aggregation of TiO 2 .…”

Section: Introductionmentioning

confidence: 99%

High-Intensity Focused Ultrasound Combined with Ti₃C₂–TiO₂ to Enhance Electrochemiluminescence of Luminol for the Sensitive Detection of Polynucleotide Kinase

Wei

Zhang

Wang

2023

ACS Appl. Mater. Interfaces

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Luminol is a classic electrochemiluminescence (ECL) luminophore. The luminol−O 2 ECL system suffers from a problem, that is, the conversion rate of dissolved O 2 into reactive oxygen species (ROS) is low. In this work, we used high-intensity focused ultrasound (HIFU) pretreatment combined with Ti 3 C 2 −TiO 2 to construct a highly sensitive luminol−O 2 ECL system for the specific detection of polynucleotide kinase (PNK) first. On the one hand, HIFU generated ROS in situ as a coreactant via the cavitation effect to boost the luminol emission. On the other hand, Ti 3 C 2 −TiO 2 was prepared in situ via Ti 3 C 2 as a reducing agent, and it can aggregate and catalyze ROS generated in situ by HIFU. Moreover, the Ti on the Ti 3 C 2 −TiO 2 surface could bind to phosphate groups through chelation, thereby realizing highly specific detection of PNK. The sensor has a linear relationship range of 1.0 × 10 −5 to 10.0 U mL −1 , and the limit of detection is 1.48 × 10 −7 U mL −1 , which is superior to most existing methods. The sensor performance in HeLa cell lysate was measured with a satisfactory result. The designed ECL biosensor has potential applications in biological analysis and clinical diagnosis. KEYWORDS: electrochemiluminescence, high-intensity focused ultrasound, Ti 3 C 2 −TiO 2 , luminol−O 2 , polynucleotide kinase

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Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO₂ nanobelts for insulin detection

Abstract: Curcumin-conjugated Au nanoparticles wrapped in zeolitic Zn2+-imidazolate cross-linked framework nanoparticles quenched the ECL of CdS-decorated TiO2 nanobelts.

Cited by 11 publications

References 28 publications

Recent Advances in Quantum Dots-Based Biosensors

Recent Advances in Quantum Dots-Based Biosensors

State-of-the-Art on the Sulfate Radical-Advanced Oxidation Coupled with Nanomaterials: Biological and Environmental Applications

High-Intensity Focused Ultrasound Combined with Ti₃C₂–TiO₂ to Enhance Electrochemiluminescence of Luminol for the Sensitive Detection of Polynucleotide Kinase

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Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO2 nanobelts for insulin detection

Abstract: Curcumin-conjugated Au nanoparticles wrapped in zeolitic Zn2+-imidazolate cross-linked framework nanoparticles quenched the ECL of CdS-decorated TiO2 nanobelts.

Cited by 11 publications

References 28 publications

Recent Advances in Quantum Dots-Based Biosensors

Recent Advances in Quantum Dots-Based Biosensors

State-of-the-Art on the Sulfate Radical-Advanced Oxidation Coupled with Nanomaterials: Biological and Environmental Applications

High-Intensity Focused Ultrasound Combined with Ti3C2–TiO2 to Enhance Electrochemiluminescence of Luminol for the Sensitive Detection of Polynucleotide Kinase

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Product

Resources

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Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO₂ nanobelts for insulin detection

High-Intensity Focused Ultrasound Combined with Ti₃C₂–TiO₂ to Enhance Electrochemiluminescence of Luminol for the Sensitive Detection of Polynucleotide Kinase