Signal multi-amplified electrochemical biosensor for voltammetric determination of tau-441 protein in biological samples using carbon nanomaterials and gold nanoparticles to hint dementia

Li, Xuanying; Jiang, Mingdi; Cheng, Jing; Ye, Mengsha; Zhang, Weiying; Jaffrézic‐Renault, Nicole; Guo, Zhenzhong

doi:10.1007/s00604-020-04273-z

Cited by 26 publications

(16 citation statements)

References 25 publications

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Section: Voltammetric Techniquementioning

confidence: 99%

“…The potentiometric sensors are also known as ion selective electrodes (ISEs) because they are often designed to generate responses with respect to the change in concentration of a specific ion [113,114]. Their setups are different from the traditional amperometric and voltammetric cells, because they often utilize two reference electrodes that measure the potential [112]. Reprinted with permission from [112], Copyright © 2020, Springer Nature.…”

Section: Potentiometric Techniquementioning

confidence: 99%

“…Their setups are different from the traditional amperometric and voltammetric cells, because they often utilize two reference electrodes that measure the potential [112]. Reprinted with permission from [112], Copyright © 2020, Springer Nature.…”

Section: Potentiometric Techniquementioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

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Section: Voltammetric Techniquementioning

confidence: 99%

Section: Potentiometric Techniquementioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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“…Tau-441 protein was detected by Li et al [ 147 ] using MWCNTs and rGO as electrode modifiers and AuNPs for signal amplification ( Figure 10 B). The synergistic effect of MWCNTs and rGO provided a better electron transfer than with both nanomaterials alone and the binding of chitosan to MWCNTs by electrostatic forces allowed the anchoring through glutaraldehyde of the capturing antibodies.…”

Section: Electrochemical Biosensors For Alzheimer’s Disease Diagnomentioning

confidence: 99%

“…At the right side the DPV curves of growing concentrations of tau-441 and the corresponding calibration curve. Reprinted by permission from Springer Nature, Microchimica Acta [ 147 ]. Copyright (2020).…”

Section: Figurementioning

confidence: 99%

Electrochemical Biosensors Based on Nanomaterials for Early Detection of Alzheimer’s Disease

Toyos-Rodríguez

Alonso

Escosura‐Muñiz

2020

Sensors

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Alzheimer’s disease (AD) is an untreatable neurodegenerative disease that initially manifests as difficulty to remember recent events and gradually progresses to cognitive impairment. The incidence of AD is growing yearly as life expectancy increases, thus early detection is essential to ensure a better quality of life for diagnosed patients. To reach that purpose, electrochemical biosensing has emerged as a cost-effective alternative to traditional diagnostic techniques, due to its high sensitivity and selectivity. Of special relevance is the incorporation of nanomaterials in biosensors, as they contribute to enhance electron transfer while promoting the immobilization of biological recognition elements. Moreover, nanomaterials have also been employed as labels, due to their unique electroactive and electrocatalytic properties. The aim of this review is to add value in the advances achieved in the detection of AD biomarkers, the strategies followed for the incorporation of nanomaterials and its effect in biosensors performance.

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Polythionine and gold nanostar-based impedimetric aptasensor for label-free detection of α-synuclein oligomers

et al. 2021

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Signal multi-amplified electrochemical biosensor for voltammetric determination of tau-441 protein in biological samples using carbon nanomaterials and gold nanoparticles to hint dementia

Cited by 26 publications

References 25 publications

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Electrochemical Biosensors Based on Nanomaterials for Early Detection of Alzheimer’s Disease

Polythionine and gold nanostar-based impedimetric aptasensor for label-free detection of α-synuclein oligomers

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