Signal Mechanisms of M2 Macrophage Activation

Röszer, Tamás

doi:10.1007/978-3-030-50480-9_4

Cited by 2 publications

(3 citation statements)

References 163 publications

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“…It has been extensively studied how bioactive molecules of diet determine macrophage functions 128,129 and eventually, diet may induce epigenetic modifications, which affect metabolism in the offspring 130 . In turn, macrophage breakdown and synthesis of lipids determines inflammation 131,132 . Early‐life metabolic imprinting by lipid metabolites and glucose thereby potentially affects ATM phenotype and may account for the immune component of childhood obesity.…”

Section: Lipid Signals Affecting Atms In the Infant Adipose Tissuementioning

confidence: 99%

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Metabolic impact of adipose tissue macrophages in the early postnatal life

Röszer

2022

Journal of Leukocyte Biology

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Adipose tissue macrophages (ATMs) play key roles in metabolic inflammation, insulin resistance, adipose tissue fibrosis, and immune disorders associated with obesity. Research on ATM biology has mostly been conducted in the setting of adult obesity, since adipocyte hypertrophy is associated with a significant increase in ATM number. Signals that control ATM activation toward a proinflammatory or a proresolving phenotype also determine the developmental program and lipid metabolism of adipocytes after birth. ATMs are present at birth and actively participate in the synthesis of mediators, which induce lipolysis, mitobiogenesis, and mitochondrial uncoupling in adipocytes. ATMs in the newborn and the infant promote a lipolytic and fatty acid oxidizing adipocyte phenotype, which is essential to support the lipid‐fueled metabolism, to maintain nonshivering thermogenesis and counteract an excessive adipose tissue expansion. Since adipose tissue metabolism in the early postnatal life determines obesity status in adulthood, early‐life ATM functions may have a life‐long impact.

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Section: Lipid Signals Affecting Atms In the Infant Adipose Tissuementioning

confidence: 99%

“… 130 In turn, macrophage breakdown and synthesis of lipids determines inflammation. 131 , 132 Early‐life metabolic imprinting by lipid metabolites and glucose thereby potentially affects ATM phenotype and may account for the immune component of childhood obesity.…”

Section: Lipid Signals Affecting Atms In the Infant Adipose Tissuementioning

confidence: 99%

Metabolic impact of adipose tissue macrophages in the early postnatal life

Röszer

2022

Journal of Leukocyte Biology

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“…The “immunologically silent” removal of apoptotic cell contents is particularly relevant when apoptotic cells are cleared from damaged, infected or inflamed tissues. Macrophages exposed to the content of apoptotic cells adopt a pro-resolving, anti-inflammatory or tolerogenic phenotype, which is often termed alternative- or M2-macrophage activation (reviewed in [ 3 , 4 ]). Apoptotic cell clearance induces interleukin-10 (IL-10) and tumor growth factor beta (TGFβ) production in macrophages concomitant with the expression of various M2-activation-associated molecules such as the high affinity scavenger receptor for the hemoglobin-haptoglobin complex CD163 and the mannose receptor CD206 [ 5 ].…”

Section: Introduction: the Impact Of Apoptotic Cell Clearance In Fat Depotsmentioning

confidence: 99%

Adipose Tissue Immunometabolism and Apoptotic Cell Clearance

Röszer¹

2021

Cells

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The safe removal of apoptotic debris by macrophages—often referred to as efferocytosis—is crucial for maintaining tissue integrity and preventing self-immunity or tissue damaging inflammation. Macrophages clear tissues of hazardous materials from dying cells and ultimately adopt a pro-resolving activation state. However, adipocyte apoptosis is an inflammation-generating process, and the removal of apoptotic adipocytes by so-called adipose tissue macrophages triggers a sequence of events that lead to meta-inflammation and obesity-associated metabolic diseases. Signals that allow apoptotic cells to control macrophage immune functions are complex and involve metabolites released by the apoptotic cells and also metabolites produced by the macrophages during the digestion of apoptotic cell contents. This review provides a concise summary of the adipocyte-derived metabolites that potentially control adipose tissue macrophage immune functions and, hence, may induce or alleviate adipose tissue inflammation.

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Signal Mechanisms of M2 Macrophage Activation

Cited by 2 publications

References 163 publications

Metabolic impact of adipose tissue macrophages in the early postnatal life

Metabolic impact of adipose tissue macrophages in the early postnatal life

Adipose Tissue Immunometabolism and Apoptotic Cell Clearance

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