“…(C) Telomerase activity of the PML-IV-stable cell lines. The extracts of H1299, mock, or stable cell lines were tested for telomerase activity as described in recruit several proteins, including CBP, p53, Hdm2 (MDM2), PIN1, HDAC7 and HCMV IE1, suggesting that unSUMOylated primary PML-NBs still have an important biological function (Bischof et al, 2002;Gao et al, 2008;Kang et al, 2006;Lallemand-Breitenbach et al, 2001;Reineke et al, 2008;Wei et al, 2003). Indeed, SUMOylation of PML is dispensable for premature senescence induced by p53, because PML3M can induce growth arrest and senescence (Bischof et al, 2002).…”