Signal and Image Processing in Biomedical Photoacoustic Imaging: A Review

Manwar, Rayyan; Zafar, Mohsin; Xu, Qiuyun

doi:10.3390/opt2010001

Cited by 56 publications

(29 citation statements)

References 160 publications

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“…S21). The carotid artery is invisible in the photoacoustic images because its strong pulsation will induce unstable phases to the photoacoustic signals and therefore skew their coherent averaging 45,46 (Fig. S22).…”

Section: In-vivo Continuous Monitoring Of the Brain Temperaturementioning

confidence: 99%

A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

Gao¹,

Chen²,

Hu³

et al. 2021

Preprint

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Electronic patches, based on various mechanisms, allow continuous and noninvasive monitoring of biomolecules on the skin surface. However, to date, such devices have been unable to sense biomolecules in deep tissues, which have a stronger and faster correlation with the human physiological status. Here, we demonstrate a photoacoustic patch for three-dimensional (3D) mapping of hemoglobin in deep tissues. This photoacoustic patch integrates an array of ultrasonic transducers and vertical-cavity surface-emitting laser (VCSEL) diodes on a common soft substrate. The high-power VCSEL diodes can generate laser pulses that penetrate >2 cm into human tissues and activate hemoglobin molecules to generate acoustic waves, which can be collected by the transducers for 3D imaging of the hemoglobin with a sub-millimeter spatial resolution. Additionally, the photoacoustic signal amplitude and temperature have a linear relationship, which allows 3D mapping of core temperatures with high accuracy and fast response. The results of 3D core temperature mapping and long-term monitoring in ex-vivo and in-vivo studies are validated by commercial devices. With access to biomolecules in deep tissues, this technology adds unprecedented functions to wearable electronics and thus holds significant implications for various applications in both basic research and clinical practice.

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Section: In-vivo Continuous Monitoring Of the Brain Temperaturementioning

confidence: 99%

A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

Gao¹,

Chen²,

Hu³

et al. 2021

Preprint

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“…However, due to structural and incident laser energy limitations, it is not feasible to maximize light delivery. Several studies have attempted to develop signal enhancement and image post-processing algorithms to either extract the original, attenuated PA signal or to improve the existing one by various filtering techniques [7,8]. Despite the excellent efforts towards PA signal/image enhancement, the available techniques do not perform as expected, especially when imaging complex and deep biological tissue structures such as brain [9][10][11] with overlaying chromophores that have high heterogeneous absorption and scattering coefficients (such as skin and skull).…”

Section: Introductionmentioning

confidence: 99%

Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain

Manwar

Lara

Prakash

et al. 2022

Journal of Biophotonics

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One of the key challenges in linear array transducer‐based photoacoustic computed tomography is to image structures embedded deep within the biological tissue with limited optical energy. Here, we utilized a manually controlled multi‐angle illumination technique to allow the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have developed and optimized a compact probe that enables manual changes to the angle of illumination while acquiring photoacoustic signals. The performance has been demonstrated and evaluated by imaging complex blood vessel mimicking phantoms in‐vitro and sheep brain samples ex‐vivo. For effective image reconstruction from the data acquired by multi‐angle illumination method, we have utilized a method based on the extraction of maximum intensity. In both cases, multi‐angle illumination has out‐performed the conventional fixed angle illumination technique to improve the overall image quality. Specifically, extraction of the imaging targets located at greater axial depths was possible using this multi‐angle illumination technique.

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“…In this imaging modality, a laser source irradiates the tissue of interest. Tissue chromophores absorber the optical energy and excite photoacoustic (PA) waves [2,3]. PA waves are recorded by ultrasound transducers and finally used to reconstruct the optical absorption distribution of the tissue [4].…”

Section: Introductionmentioning

confidence: 99%

Finite Transducer Size Compensation in Two-Dimensional Photoacoustic Computed Tomography

Hakakzadeh

Mozaffarzadeh

Mostafavi

et al. 2021

2021 IEEE International Ultrasonics Symposium (IUS)

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In circular photoacoustic computed tomography, for data acquisition, a single-element transducer rotates around the region of interest (ROI). Due to the limited acceptance angle of the finite size transducer, the reconstructed image becomes blurred, and tangential resolution/contrast degrades in off-center locations in the ROI. In this paper, we propose a compensation method in which in addition to the circular scanning, the transducer rotates around its center (with specific angles) at each detection point. The superposition of these central rotations and non-rotated transducer mimics a virtual detector with a wide acceptance angle. The angles are calculated based on the central frequency and diameter of the transducer and the radius of the region-of-interest. Three types of numerical phantom (point-like, vasculature and Derenzo) were used to evaluate the performance of our method. Features of Olympus NDT, V326-SU transducer were used to assemble the numerical data. The results show that the proposed method provides better structural information by lowering the image blurring, improves the tangential resolution by 90% and increases peak signal-to-noise ratio by 14%.

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Signal and Image Processing in Biomedical Photoacoustic Imaging: A Review

Cited by 56 publications

References 160 publications

A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature

Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain

Finite Transducer Size Compensation in Two-Dimensional Photoacoustic Computed Tomography

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