In this paper, we study the following nonlinear fractional Schrödinger-Poisson system (-) s u + V(x)u + φu = K(x)f (u), x ∈ R 3 , (-) t φ = u 2 , x ∈ R 3. (0.1) where s ∈ (3 4 , 1), t ∈ (0, 1), V, K : R 3 → R are continuous functions verifying some conditions about zero mass. By using the constraint variational method and the quantitative deformation lemma, we obtain the existence of least energy sign-changing solution to this system.