In this paper, we are concerned with the quasilinear Schrödinger equationwhere N ≥ 3, V is radially symmetric and nonnegative, and g is asymptotically 3linear at infinity. In the case of inf R N V > 0, we show the existence of a least energy sign-changing solution with exactly one node, and for any integer k > 0, there are a pair of sign-changing solutions with k nodes. Moreover, in the case of inf R N V = 0, the problem above admits a least energy sign-changing solution with exactly one node. The proof is based on variational methods. In particular, some new tricks and the method of sign-changing Nehari manifold depending on a suitable restricted set are introduced to overcome the difficulty resulting from the appearance of asymptotically 3-linear nonlinearities.