We extend the axiomatization for detecting and quantifying sign changes of Meher and Murty [23] to sequences of complex numbers. We further generalize this result when the sequence is comprised of the coefficients of an L-function. As immediate applications, we prove that there are sign changes in intervals within sequences of coefficients of GL(2) holomorphic cusp forms, GL(2) Maass forms, and GL(3) Maass forms. Building on [12, 13], we prove that there are sign changes in intervals within sequences of partial sums of coefficients of GL (2) holomorphic cusp forms and Maass forms.