Sigmoid Volvulus in Association With Parkinsonism Report of Four Cases

Rosenthal, Mark J.; Marshall, Charles E.

doi:10.1111/j.1532-5415.1987.tb04346.x

Cited by 47 publications

(20 citation statements)

References 8 publications

(11 reference statements)

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“…Yokoyama and Hasegawa [161] have recently reported the frequency to be 7.1% among 112 patients with PD. Radiographical features of intestinal pseudo-obstruction are dilatation of colon and small intestine [160, 162–164]. True obstruction due to volvulus in PD also occur [161, 163, 164].…”

Section: Bowel Dysfunction In Pdmentioning

confidence: 99%

Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease

Sakakibara

Kusumoto

Ogawa

et al. 2011

Parkinson's Disease

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Bladder dysfunction (urinary urgency/frequency), bowel dysfunction (constipation), and sexual dysfunction (erectile dysfunction) (also called “pelvic organ” dysfunctions) are common nonmotor disorders in Parkinson's disease (PD). In contrast to motor disorders, pelvic organ autonomic dysfunctions are often nonresponsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine-basal ganglia circuit, which normally suppresses the micturition reflex. By contrast, peripheral myenteric pathology causing slowed colonic transit (loss of rectal contractions) and central pathology causing weak strain and paradoxical anal sphincter contraction on defecation (PSD, also called as anismus) are responsible for the bowel dysfunction. In addition, hypothalamic dysfunction is mostly responsible for the sexual dysfunction (decrease in libido and erection) in PD, via altered dopamine-oxytocin pathways, which normally promote libido and erection. The pathophysiology of the pelvic organ dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. Dietary fibers, laxatives, and “prokinetic” drugs such as serotonergic agonists are used to treat bowel dysfunction in PD. Phosphodiesterase inhibitors are used to treat sexual dysfunction in PD. These treatments might be beneficial in maximizing the patients' quality of life.

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Section: Bowel Dysfunction In Pdmentioning

confidence: 99%

Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease

Sakakibara

Kusumoto

Ogawa

et al. 2011

Parkinson's Disease

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“…Recent studies have underscored their significance in determining quality of life [7][8][9][10]. Furthermore, GI symptoms have been associated with severe and potentially life-threatening complications, including malnutrition, pulmonary aspiration, megacolon, intestinal obstruction, and even perforation [11][12][13][14][15][16]. They rank among the most common causes of emergency admission in the PD population [17].…”

Section: Introductionmentioning

confidence: 98%

Gastrointestinal Features of Parkinson’s Disease

Cloud

Greene

2011

Curr Neurol Neurosci Rep

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Gastrointestinal (GI) symptoms are among the most common nonmotor manifestations of Parkinson's disease (PD), and they have many important ramifications for patients. The purpose of this review is to raise awareness of the full spectrum of GI symptoms in PD which include weight loss, sialorrhea, dysphagia, nausea, constipation, and defecatory dysfunction. We will discuss their practical significance, and outline a clear approach to their evaluation and management. A brief discussion about the impacts of commonly used medical and surgical PD therapies on GI symptom manifestation is also included.

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“…Unfortunately, patients frequently have recurrent volvulus after endoscopic detorsion making primary resection and anastomosis the preferred therapeutic approach in many cases [7], [8], [9]. Patients with sigmoid volvulus are often institutionalized, debilitated and usually suffering from neurogenic and psychological disorders [7], [14], [15], [16]. Many have complex comorbidities [10], [11] that place them at a substantial risk for postoperative complications with the traditional surgical approach for sigmoid volvulus.…”

Section: Introductionmentioning

confidence: 99%