Sigmoid colon cancer arising in a diverticulum of the colon with involvement of the urinary bladder: a case report and review of the literature

Yagi, Yasushi; Shoji, Yasuhiro; Sasaki, Shin; Yoshikawa, Akira; Tsukioka, Yuji; Fukushima, Wataru; Higuchi, Hisashi; Izumi, Ryohei; Saito, Katsuhiko

doi:10.1186/1471-230x-14-90

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…Furthermore, patients with COAD in the sigmoid colon had considerably greater levels of PFKFB4 expression than those with COAD in other parts of the colon. This may be linked to the fact that sigmoid colon is the most common site of COAD, which is located in the right colon and tends to be more malignant 24 . However, the investigation did not find any direct relationship between PFKFB4 expression and patient age, gender, tumor differentiation, size, depth of invasion, lymph node metastasis, or distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients

Gu,

Dai,

Huang

et al. 2023

Sci Rep

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Colon adenocarcinoma (COAD) is a common malignant tumor, and the role of the protein PFKFB4 in glycolysis and pentose phosphate pathways is crucial. Researchers investigated the clinical significance of PFKFB4 in COAD by studying its expression in 79 tissue samples using immunohistochemistry. We found that PFKFB4 expression was significantly higher in COAD patients, particularly in the sigmoid colon. Interestingly, high PFKFB4 expression was associated with both improved overall survival (OS) and worse progression-free survival (PPS) in COAD patients. Further analysis revealed that genes associated with PFKFB4 were linked to various metabolic pathways, including amino acid biosynthesis, glycolysis, gluconeogenesis, glucose metabolism, and inflammatory response. PFKFB4 expression also showed correlations with the infiltration of different immune cell types in COAD patients, such as CD8+ T cells, CD4+ T cells, regulatory T cells (Tregs), macrophages, neutrophils, dendritic cells, active mast cells, and resting NK cells. Overall, the relationship between PFKFB4 expression and the prognosis of COAD is complex and diverse, possibly playing different roles at different stages of the disease. Moreover, its mechanism might involve interactions with various metabolic pathways and immune infiltration in the tumor microenvironment. These findings provide valuable insights into the potential role of PFKFB4 as a biomarker or therapeutic target in COAD.

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Section: Discussionmentioning

confidence: 99%

Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients

Gu,

Dai,

Huang

et al. 2023

Sci Rep

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“…The presence of a larger inflamed diverticulum showing a conical or pointed appearance and associated pericolic findings is mostly associated with acute diverticulitis. However, malignancy within a large diverticulum has also been documented as a rare entity [8]. A few studies have noted the significance of the increased number of diverticula in benign causes.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Isolated Sigmoid Colon Thickening Detected on Routine Computed Tomography Examinations

Waheed

Aljassim

2023

SaudiRad

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Objective To determine outcomes of isolated sigmoid colon thickening detected on computed tomography (CT) and to evaluate certain clinical and CT findings that could help in diagnoses. Method This retrospective observational study was performed evaluating CT imaging data of all consecutive adult patients who presented with acute lower abdominal pains in emergency departments and were found to have isolated sigmoid colonic thickening on routine venous phase CT studies, between January 2020 to January 2022. Pre- viously operated cases, known inflammatory bowel disease patients, and those with known sigmoid malignancies were excluded. CT findings regarding the length of the sigmoid segment affected (less or more than 10 cm), mucosal pattern (symmet- ric or asymmetric), presence of diverticula, lymph nodes, and additional features (pericolic abscess or fistula formation, extra-luminal air foci or perforation, local invasion) were documented. Two experienced radiologists made consensus report- ing. Final diagnoses were confirmed on (endoscopic) biopsy results. Patients who did not have endoscopies or were medically treated were excluded. Age, gender, and CT findings were compared with outcomes, and any association was determined by the Chi-squared test. Results Out of 30 patients (aged between 20-75 years), the majority were males (n=21) and above 40 years (n=22). Twelve patients had colonic malignancies while 18 had benign findings. Acute presentation, younger patients, and those showing the presence of diver- ticula on CT scans were associated with benign biopsies. Conclusion Younger patients who present acutely and show diverticula on CT imaging may have benign causes of sigmoid thickening.

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“…Furthermore, patients with COAD in the sigmoid colon had considerably greater levels of PFKFB4 expression than those with COAD in other parts of the colon. This may be linked to the fact that sigmoid colon is the most common site of COAD, which is located in the right colon and tends to be more malignant 24 . However, the investigation did not nd any direct relationship between PFKFB4 expression and patient age, gender, tumor differentiation, size, depth of invasion, lymph node metastasis, or distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Differential Roles of Highly Expressed PFKFB4 across Stages in Colon Adenocarcinoma Patients

Dai

Huang

et al. 2023

Preprint

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Colon adenocarcinoma (COAD) is a common malignant tumor, and the role of the protein PFKFB4 in glycolysis and pentose phosphate pathways is crucial. Researchers investigated the clinical significance of PFKFB4 in COAD by studying its expression in 79 tissue samples using immunohistochemistry. They found that PFKFB4 expression was significantly higher in COAD patients, particularly in the sigmoid colon. Interestingly, high PFKFB4 expression was associated with both improved overall survival (OS) and worse progression-free survival (PPS) in COAD patients. Further analysis revealed that genes associated with PFKFB4 were linked to various metabolic pathways, including amino acid biosynthesis, glycolysis, gluconeogenesis, glucose metabolism, and inflammatory response. PFKFB4 expression also showed correlations with the infiltration of different immune cell types in COAD patients, such as CD8 + T cells, CD4 + T cells, regulatory T cells (Tregs), macrophages, neutrophils, dendritic cells, active mast cells, and resting NK cells. Overall, the relationship between PFKFB4 expression and the prognosis of COAD is complex and diverse, possibly playing different roles at different stages of the disease. Moreover, its mechanism might involve interactions with various metabolic pathways and immune infiltration in the tumor microenvironment. These findings provide valuable insights into the potential role of PFKFB4 as a biomarker or therapeutic target in COAD.

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Sigmoid colon cancer arising in a diverticulum of the colon with involvement of the urinary bladder: a case report and review of the literature

Cited by 9 publications

References 12 publications

Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients

Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients

Outcomes of Isolated Sigmoid Colon Thickening Detected on Routine Computed Tomography Examinations

Differential Roles of Highly Expressed PFKFB4 across Stages in Colon Adenocarcinoma Patients

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