Abstract:Purpose of Review This review will summarize ocular gene therapy clinical trials and associated technology that have been initiated within the last 5 years. Recent Findings Initial programs utilized subretinal administration of an AAV2 serotype coupled with a ubiquitous promoter and a transgene targeting both monogenic inherited retinal diseases and acquired chronic ocular diseases polygenic in origin such as age-related macular degeneration and diabetic retinopathy. Cellular specific viral vectors with optimi… Show more
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