SIFamide and SIFamide Receptor Define a Novel Neuropeptide Signaling to Promote Sleep in Drosophila

Park, Sangjin; Sonn, Jun Young; Oh, Yang Kyun; Lim, Chunghun; Choe, Joonho

doi:10.14348/molcells.2014.2371

Cited by 72 publications

(66 citation statements)

References 37 publications

(45 reference statements)

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“…SIFamide is a well conserved neuropeptide in insects and crustaceans79. In insects, SIFamide has been proven to have a role in sexual behaviour80 and promote sleep in Drosophila melanogaster 81.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic characterization and curation of candidate neuropeptides regulating reproduction in the eyestalk ganglia of the Australian crayfish, Cherax quadricarinatus

Nguyen

Cummins

Elizur

et al. 2016

Sci Rep

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The Australian redclaw crayfish (Cherax quadricarinatus) has recently received attention as an emerging candidate for sustainable aquaculture production in Australia and worldwide. More importantly, C. quadricarinatus serves as a good model organism for the commercially important group of decapod crustaceans as it is distributed worldwide, easy to maintain in the laboratory and its reproductive cycle has been well documented. In order to better understand the key reproduction and development regulating mechanisms in decapod crustaceans, the molecular toolkit available for model organisms such as C. quadricarinatus must be expanded. However, there has been no study undertaken to establish the C. quadricarinatus neuropeptidome. Here we report a comprehensive study of the neuropeptide genes expressed in the eyestalk in the Australian crayfish C. quadricarinatus. We characterised 53 putative neuropeptide-encoding transcripts based on key features of neuropeptides as characterised in other species. Of those, 14 neuropeptides implicated in reproduction regulation were chosen for assessment of their tissue distribution using RT-PCR. Further insights are discussed in relation to current knowledge of neuropeptides in other species and potential follow up studies. Overall, the resulting data lays the foundation for future gene-based neuroendocrinology studies in C. quadricarinatus.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic characterization and curation of candidate neuropeptides regulating reproduction in the eyestalk ganglia of the Australian crayfish, Cherax quadricarinatus

Nguyen

Cummins

Elizur

et al. 2016

Sci Rep

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“…For example, the involvement of dopaminergic, GABAergic, and peptidergic neurons are well characterized142643444546. In particular, Drosophila sleep/wake behaviors is modified by several neuropeptides, including the short neuropeptide F, neuropeptide F, SIFamide, and Ion transport peptide4748495051. Previous studies have revealed that Ap is necessary for expression of neuropeptides [FMRFamide and Leucokinin (Lk)] in the central nervous system910.…”

Section: Discussionmentioning

confidence: 99%

Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain

Shimada

Inami

Sato

et al. 2016

Sci Rep

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Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake regulation in adult flies. PDF-expressing neurons consist of two neuronal clusters: small ventral-lateral neurons (s-LNvs) acting as the circadian pacemaker and large ventral-lateral neurons (l-LNvs) regulating light-driven arousal. We identified that Ap localizes to the nuclei of s-LNvs and l-LNvs. In light-dark (LD) cycles, RNAi knockdown or the targeted expression of dominant-negative forms of Ap or Chi in PDF-expressing neurons or l-LNvs promoted arousal. In contrast, in constant darkness, knockdown of Ap in PDF-expressing neurons did not promote arousal, indicating that a reduced Ap function in PDF-expressing neurons promotes light-driven arousal. Furthermore, Ap expression in l-LNvs showed daily rhythms (peaking at midnight), which are generated by a direct light-dependent mechanism rather than by the endogenous clock. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies.

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“…For example, the neuropeptide pigment dispersing factor (PDF) is involved in both arousal (Parisky et al, 2008; Sheeba et al, 2008) and clock output mechanisms (Renn et al, 1999). Recent work has shown sleep promoting roles of SIFamide (Park et al, 2014) and sNPF (Shang et al, 2013) secreted from pars intercerebralis and small ventrolateral clock cells, respectively. The precise role of sNPF, which, Like FMRFa, is a member of the FaRP family (Nassel and Winther, 2010), remains uncertain since it has also been reported to serve a wake-promoting role (Chen et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

FMRFamide signaling promotes stress-induced sleep in Drosophila

Lenz

Xiong

Nelson

et al. 2015

Brain, Behavior, and Immunity

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Enhanced sleep in response to cellular stress is a conserved adaptive behavior across multiple species, but the mechanism of this process is poorly understood. Drosophila melanogaster increases sleep following exposure to septic or aseptic injury, and Caenorhabditis elegans displays sleep-like quiescence following exposure to high temperatures that stress cells. We show here that, similar to C. elegans, Drosophila responds to heat stress with an increase in sleep. In contrast to Drosophila infection-induced sleep, heat-induced sleep is not sensitive to the time-of-day of the heat pulse. Moreover, the sleep response to heat stress does not require Relish, the NFκB transcription factor that is necessary for infection-induced sleep, indicating that sleep is induced by multiple mechanisms from different stress modalities. We identify a sleep-regulating role for a signaling pathway involving FMRFamide neuropeptides and their receptor FR. Animals mutant for either FMRFamide or for the FMRFamide receptor (FR) have a reduced recovery sleep in response to heat stress. FR mutants, in addition, show reduced sleep responses following infection with Serratia marcescens, and succumb to infection at a faster rate than wild-type controls. Together, these findings support the hypothesis that FMRFamide and its receptor promote an adaptive increase in sleep following stress. Because an FMRFamide-like neuropeptide plays a similar role in C. elegans, we propose that FRMFamide neuropeptide signaling is an ancient regulator of recovery sleep which occurs in response to cellular stress.

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SIFamide and SIFamide Receptor Define a Novel Neuropeptide Signaling to Promote Sleep in Drosophila

Cited by 72 publications

References 37 publications

Transcriptomic characterization and curation of candidate neuropeptides regulating reproduction in the eyestalk ganglia of the Australian crayfish, Cherax quadricarinatus

Transcriptomic characterization and curation of candidate neuropeptides regulating reproduction in the eyestalk ganglia of the Australian crayfish, Cherax quadricarinatus

Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain

FMRFamide signaling promotes stress-induced sleep in Drosophila

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