“…For example, mice lacking SIDT2 demonstrate impaired glucose tolerance, decreased serum insulin levels, and defective insulin secretion (Chang et al., 2016, Gao et al., 2013, Yu et al., 2015). Two recent studies also demonstrated that Sidt2 −/− mice develop non-alcoholic fatty liver disease (Chen et al., 2018, Gao et al., 2016), with one suggesting that this is due to induction of endoplasmic reticulum stress (Gao et al., 2016) and the other proposing that it is the result of defective autophagy (Chen et al., 2018). Finally, work from our group has also demonstrated a potential role for SIDT2 in tumorigenesis (Brady et al., 2011).…”