SIDS symposium – A perspective for future research

Waters, Karen A.

doi:10.1016/j.prrv.2014.09.005

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Although prone sleeping campaigns, such as “Back to Sleep” reduced SIDS and postneonatal mortality rates in the 1990s (9), their effect was uneven in different countries (10). Subsequent to 1999, the plateau, or slower decline in SIDS rates, has been associated with a diagnostic shift from classification of SIDS deaths (11, 12) to a concurrent increase in rates of other categories of sleep associated sudden and unexpected infant deaths attributed to accidental suffocation and strangulation in bed or “unknown” causes (13), questioning the magnitude of the actual decrease in SIDS deaths (14, 15).…”

Section: Introductionmentioning

confidence: 99%

A “Wear and Tear” Hypothesis to Explain Sudden Infant Death Syndrome

Elhaik

2016

Front. Neurol.

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Sudden infant death syndrome (SIDS) is the leading cause of death among USA infants under 1 year of age accounting for ~2,700 deaths per year. Although formally SIDS dates back at least 2,000 years and was even mentioned in the Hebrew Bible (Kings 3:19), its etiology remains unexplained prompting the CDC to initiate a sudden unexpected infant death case registry in 2010. Due to their total dependence, the ability of the infant to allostatically regulate stressors and stress responses shaped by genetic and environmental factors is severely constrained. We propose that SIDS is the result of cumulative painful, stressful, or traumatic exposures that begin in utero and tax neonatal regulatory systems incompatible with allostasis. We also identify several putative biochemical mechanisms involved in SIDS. We argue that the important characteristics of SIDS, namely male predominance (60:40), the significantly different SIDS rate among USA Hispanics (80% lower) compared to whites, 50% of cases occurring between 7.6 and 17.6 weeks after birth with only 10% after 24.7 weeks, and seasonal variation with most cases occurring during winter, are all associated with common environmental stressors, such as neonatal circumcision and seasonal illnesses. We predict that neonatal circumcision is associated with hypersensitivity to pain and decreased heart rate variability, which increase the risk for SIDS. We also predict that neonatal male circumcision will account for the SIDS gender bias and that groups that practice high male circumcision rates, such as USA whites, will have higher SIDS rates compared to groups with lower circumcision rates. SIDS rates will also be higher in USA states where Medicaid covers circumcision and lower among people that do not practice neonatal circumcision and/or cannot afford to pay for circumcision. We last predict that winter-born premature infants who are circumcised will be at higher risk of SIDS compared to infants who experienced fewer nociceptive exposures. All these predictions are testable experimentally using animal models or cohort studies in humans. Our hypothesis provides new insights into novel risk factors for SIDS that can reduce its risk by modifying current infant care practices to reduce nociceptive exposures.

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Section: Introductionmentioning

confidence: 99%

A “Wear and Tear” Hypothesis to Explain Sudden Infant Death Syndrome

Elhaik

2016

Front. Neurol.

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“…Identification and decreasing these factors leading to a decrease in SIDS cases in the last two decades (6). A "Back to Sleep" campaign in 1990 leading to a number of decreasing cases (7). But still, the ratio is high in developing countries like Pakistan in which people are less aware of this condition.…”

Section: Introductionmentioning

confidence: 99%

Sudden Infant Death Syndrome: A Case Report in Pakistan

2019

JMPB

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Sudden infant death syndrome (SIDS) is the sudden death of an infant without any identified cause after a complete autopsy report, death scene investigation and from parent's history. There is little published literature or statistics present in a developing country like Pakistan. So the aim of this study was to identify those factors that are associated with Sudden infant death syndrome in relation to Pakistani culture. The case report was based on a case of two months old baby previously healthy was found dead on his crib. The autopsy report and investigation of the scene giving non-specified symptoms further, diagnose the case as Sudden infant death syndrome. The study found that in our culture early marriages, inadequate knowledge regarding child-rearing and traditional use of Quilts for children are the major contributing factors in the prevention of Sudden infant death syndrome.

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SIDS symposium – A perspective for future research

Cited by 2 publications

References 10 publications

A “Wear and Tear” Hypothesis to Explain Sudden Infant Death Syndrome

A “Wear and Tear” Hypothesis to Explain Sudden Infant Death Syndrome

Sudden Infant Death Syndrome: A Case Report in Pakistan

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