Siderophores: Importance in bacterial pathogenesis and applications in medicine and industry

Khasheii, Behnoush; Mahmoodi, Pezhman; Mohammadzadeh, Abdolmajid

doi:10.1016/j.micres.2021.126790

Cited by 79 publications

(62 citation statements)

References 171 publications

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Section: Discussionmentioning

confidence: 99%

“…Siderophores (high-affinity iron chelating molecules) have been received special attention as essential virulence factors of bacteria, acting as a toxin and/or modulator of the immune system of the host ( 42 – 45 ). Strains that can produce more siderophores are considered highly virulent ( 45 ). In this study, more than 40% E. coli strains also carried siderophore (aerobactin, yersiniabactin, salmochelin, and enterobactin)-encoding genes.…”

Section: Discussionmentioning

confidence: 99%

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WHO Critical Priority Escherichia coli as One Health Challenge for a Post-Pandemic Scenario: Genomic Surveillance and Analysis of Current Trends in Brazil

et al. 2022

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A One Health approach for antimicrobial resistance must integrate whole-genome sequencing surveillance data of critical priority pathogens from human, animal and environmental sources to track hot spots and routes of transmission and developing effective prevention and control strategies. As part of the Grand Challenges Explorations: New Approaches to Characterize the Global Burden of Antimicrobial Resistance Program, we present genomic data of WHO critical priority carbapenemase-resistant, ESBL-producing, and/or colistin-resistant Escherichia coli strains isolated from humans and nonhuman sources in Brazil, a country with continental proportions and high levels of antimicrobial resistance.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

WHO Critical Priority Escherichia coli as One Health Challenge for a Post-Pandemic Scenario: Genomic Surveillance and Analysis of Current Trends in Brazil

et al. 2022

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“…The supply of iron is usually limited during a pathogen infection, which is an essential trace element, so adaptation to iron starvation is crucial for virulence ( Blatzer and Latge, 2017 ). M. robertsii may compete iron with pests to achieve pest control, which is similar to that of A. fumigatus that deficiency of siderophores lead to a reduction in pathogenicity ( Weinberg, 1974 ; Nairz et al, 2018 ; Khasheii et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Differences Guided Discovery and Genetic Identification of Coprogen and Dimerumic Acid Siderophores in Metarhizium robertsii

Zhang

Zeng

et al. 2021

Front. Microbiol.

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Siderophores are small molecular iron chelators and participate in the multiple cellular processes in fungi. In this study, biosynthesis gene clusters of coprogens and dimerumic acids were identified by transcriptional level differences of genes related to iron deficiency conditions in Metarhizium robertsii. This leads to the characterization of new coprogen metachelin C (1) and five known siderophores metachelin A (2), metachelin A-CE (3), metachelin B (4), dimerumic acid 11-mannoside (5), and dimerumic acid (6). The structure of metachelin C (1) was elucidated by NMR spectroscopy and HR-ESI-MS analysis. Genetic deletions of mrsidA, and mrsidD abolished the production of compounds 1–6 that implied their involvement in the biosynthesis of coprogen and dimerumic acid. Interestingly, NRPS gene mrsidD is responsible for biosynthesis of both coprogen and dimerumic acid, thus we proposed plausible biosynthetic pathways for the synthesis of coprogen and dimerumic acid siderophores. Therefore, our study provides the genetic basis for understanding the biosynthetic pathway of coprogen and dimerumic acid in Metarhizium robertsii.

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“…In fact, pathogens that produce an excessive number of siderophores are referred to as hypervirulent, whereas pathogens that cannot produce siderophores have lower virulence during infections (Holden and Bachman 2015 ). Additionally, deletion of genes responsible for siderophore biosynthesis has been associated with reduced virulence in pathogens such as Gram-positive and Gram-negative bacteria (Khasheii et al 2021 ). Differentiation of siderophore biosynthesis may impart new or improved properties to the siderophore, causing the bacterium to become more virulent.…”

Section: Introductionmentioning

confidence: 99%

Characterization of siderophores from Escherichia coli strains through genome mining tools: an antiSMASH study

Çavaş

Kirkiz

2022

AMB Expr

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Although urinary tract infections (UTIs) affect many people, they are usually a disease observed in women. UTIs happen when exogenous and endogenous bacteria enter the urinary tract and colonize there. Cystitis and pyelonephritis occur when bacteria infect the bladder and the kidneys, respectively. UTIs become much serious if the bacteria causing the infection are antibiotic resistant. Since the pathogenic microorganisms have been adopted to current antibiotics via genetic variations, UTIs have become an even more severe health problem. Therefore, there is a great need for the discovery of novel antibiotics. Genome mining of nonpathogenic and pathogenic Escherichia coli strains for investigating secondary metabolites were conducted by the antiSMASH analysis. When the resulting secondary metabolites were examined, it was found that some of the siderophores are effective in UTIs. In conclusion, since the siderophore production in E. coli is directly related to UTIs, these molecules can be a good target for development of future pharmaceutical approaches and compounds. Siderophores can also be used in industrial studies due to their higher chelating affinity for iron.

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Siderophores: Importance in bacterial pathogenesis and applications in medicine and industry

Cited by 79 publications

References 171 publications

WHO Critical Priority Escherichia coli as One Health Challenge for a Post-Pandemic Scenario: Genomic Surveillance and Analysis of Current Trends in Brazil

WHO Critical Priority Escherichia coli as One Health Challenge for a Post-Pandemic Scenario: Genomic Surveillance and Analysis of Current Trends in Brazil

Transcriptional Differences Guided Discovery and Genetic Identification of Coprogen and Dimerumic Acid Siderophores in Metarhizium robertsii

Characterization of siderophores from Escherichia coli strains through genome mining tools: an antiSMASH study

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