Siderophore production and biofilm formation as linked social traits

Harrison, Freya; Buckling, Angus

doi:10.1038/ismej.2009.9

Cited by 84 publications

(71 citation statements)

References 19 publications

(22 reference statements)

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“…In fact, comparisons of different Acinetobacter genomes have shown that the presence of genes involving siderophore biosynthesis is predictive of high or low virulence [5]. Consistently, in bacteria including Acinetobacter baumannii , siderophores were shown as necessary components for the development of surface attachment and extracellular polysaccharide synthesis (termed biofilm formation) [6–8] and the establishment of mutually-beneficial, iron-sufficient microbial communities [9]. Given that siderophores are involved in biofilm formation which promotes antibiotic resistance [10, 11], targeting siderophores by blocking siderophore synthesis or function provides a promising alternative antimicrobial approach.…”

Section: Siderophores: Important Virulence Factors and Promising Molementioning

confidence: 99%

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

Wilson

Bogdan

Miyazawa

et al. 2016

Trends in Molecular Medicine

355

319

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Iron is an essential nutrient for life. During infection, a fierce battle of iron acquisition occurs between the host and bacterial pathogens. Bacteria acquire iron by secreting siderophores, small ferric iron binding molecules. In response, host immune cells secrete lipocalin 2 (also known as siderocalin), a siderophore-binding protein, to prevent bacterial reuptake of iron-loaded siderophores. To counter this threat, some bacteria can produce lipocalin 2-resistant siderophores. This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen siderophore machinery for the treatment of antibiotic-resistant bacterial infections. As the latter reflect a persistent problem in hospital settings, siderophore-targeting or siderophore-based compounds represent a promising avenue to combat such infections.

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Section: Siderophores: Important Virulence Factors and Promising Molementioning

confidence: 99%

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

Wilson

Bogdan

Miyazawa

et al. 2016

Trends in Molecular Medicine

355

319

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“…Antagonistic interactions could include negative effects of competition, predation (Meyer and Kassen, 2007), parasitism (Buckling and Rainey, 2002) or social cheating (Rainey and Rainey, 2003;Harrison and Buckling, 2009) that favor variation but can reduce productivity. The environmental structure of biofilms could also enable diverse populations to coexist that would not persist in mixed, mass-action environments (Rainey and Travisano, 1998;Habets et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Ecological succession in long-term experimentally evolved biofilms produces synergistic communities

2010

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Many biofilm populations are known for their exceptional biodiversity, but the relative contributions of the forces that could produce this diversity are poorly understood. This uncertainty grows in the old, well-established communities found on many natural surfaces and in long-term, chronic infections. If the prevailing interactions among species within biofilms are positive, productivity should increase with diversity, but if they tend towards competition or antagonism, productivity should decrease. Here, we describe the parallel evolution of synergistic communities derived from a clone of Burkholderia cenocepacia during B1500 generations of biofilm selection. This long-term evolution was enabled by a new experimental method that selects for daily cycles of colonization, biofilm assembly and dispersal. Each of the six replicate biofilm populations underwent a common pattern of adaptive morphological diversification, in which three ecologically distinct morphotypes arose in the same order of succession and persisted. In two focal populations, mixed communities were more productive than any monoculture and each variant benefited from the mixture. These gains in output resulted from asymmetrical cross-feeding between ecotypes and the expansion and partitioning of biofilm space that constructed new niches. Therefore, even in the absence of starting genetic variation, prolonged selection for surface colonization generates a dynamic of ecological succession that enhances productivity.

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“…A growing body of empirical work has shown that genotypic mixing has the potential to limit cooperativity in a wide range of microbial traits (26,27), including enzyme secretion (20), iron scavenging (28), quorum sensing, and fruiting body formation (29,30). Genetic mixing experiments also reveal the importance of the fitness costs and benefits for social phenotypes, with the potential for cooperation to be stabilized by either constraints on competitive traits (31,32) or strategies that make cooperation carry little or no cost (22).…”

mentioning

confidence: 99%

Social evolution in multispecies biofilms

Mitri

Xavier

Foster

2011

Proc. Natl. Acad. Sci. U.S.A.

216

245

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Microbial ecology is revealing the vast diversity of strains and species that coexist in many environments, ranging from free-living communities to the symbionts that compose the human microbiome. In parallel, there is growing evidence of the importance of cooperative phenotypes for the growth and behavior of microbial groups. Here we ask: How does the presence of multiple species affect the evolution of cooperative secretions? We use a computer simulation of spatially structured cellular groups that captures key features of their biology and physical environment. When nutrient competition is strong, we find that the addition of new species can inhibit cooperation by eradicating secreting strains before they can become established. When nutrients are abundant and many species mix in one environment, however, our model predicts that secretor strains of any one species will be surrounded by other species. This "social insulation" protects secretors from competition with nonsecretors of the same species and can improve the prospects of within-species cooperation. We also observe constraints on the evolution of mutualistic interactions among species, because it is difficult to find conditions that simultaneously favor both withinand among-species cooperation. Although relatively simple, our model reveals the richness of interactions between the ecology and social evolution of multispecies microbial groups, which can be critical for the evolution of cooperation.mutualism | microbe | spatial organization | extracellular secretion | interspecies

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Siderophore production and biofilm formation as linked social traits

Cited by 84 publications

References 19 publications

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

Ecological succession in long-term experimentally evolved biofilms produces synergistic communities

Social evolution in multispecies biofilms

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