Side-related differences in sudden sensorineural hearing loss in children

Chen, Kaitian; Jiang, Hongyan; Zong, Ling; Wu, Xuan

doi:10.1016/j.ijporl.2018.08.022

Cited by 14 publications

(24 citation statements)

References 19 publications

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“…All studies were observational chart reviews. Ten studies 2,6–9,14–18 were case series (Oxford Centre for Evidence‐Based Medicine level of evidence 4). Three 1,3,19 were cohort studies (level of evidence 3), and none were clinical trials.…”

Section: Resultsmentioning

confidence: 99%

“… ‡ For one patient in Tarshish et al, 16 systemic steroid treatment history was unknown, but it was stated that no patient received intratympanic steroid treatment. Intratympanic steroid treatment in patients in Chen et al 7 was delineated by case rather than by ear. …”

Section: Resultsmentioning

confidence: 99%

“… These were the categories used in the study with the greatest number of subjects, 17 and PTA in five additional studies could also be grouped in these categories 6,7,9,14,16 . Although hearing was also categorized in two others, 2,19 they defined the categories differently. …”

Section: Resultsmentioning

confidence: 99%

“…The etiologies of SSNHL include infection, vascular injury, autoimmune disease, neoplastic processes, and inner ear anomalies. However, despite a thorough workup, the majority of patients do not have an identifiable etiology 6,7 . Studies have shown that prompt treatment is one of the most consistent prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

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Sudden Sensorineural Hearing Loss in Children—Management and Outcomes: A Meta‐analysis

2020

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Objective To identify which patient characteristics and treatments are associated with hearing improvement in patients with pediatric sudden sensorineural hearing loss (SSNHL). Methods PubMed, Web of Science, Cochrane Library, PsycINFO, and Cumulative Index to Nursing and Allied Health Literature were systematically searched for articles published before February 5, 2019, and references of relevant articles were screened. Original English‐language case series and cohort studies were included if they addressed SSNHL in patients <20 years of age. Study characteristics, patient demographics, symptoms, treatments, and hearing outcomes were extracted. The primary outcome was hearing improvement. Results Thirteen studies were included, totaling 605 patients (670 ears). Hearing did not improve in 46.7% of ears (95% confidence interval [CI]: 34.4% to 59.0%). Imaging (computed tomography and/or magnetic resonance imaging) results were described in three studies, and 24.2% of ears (95% CI: 7.7% to 40.6%) had abnormal findings. The most common serological finding was cytomegalovirus immunoglobulin (Ig)G or IgM (34.3% of ears tested, 95% CI: −2.9% to 71.6%). Unilateral hearing loss (odds ratio [OR]:3.85, P < .001), tinnitus (OR: 2.20, P = .003), age >12 years (OR: 2.11, P = .002), and ascending audiogram (OR: 3.66, P = .005), but not systemic or intratympanic steroids, were associated with increased odds of partial or complete improvement. In contrast, profound hearing loss (OR: 0.29, P < .001) and treatment delay of >6 days (OR: 0.27, P < .001) were associated with decreased odds of improvement. Conclusions Despite treatment, half of patients had no improvement in hearing. Prognostic factors associated with hearing improvement were generally consistent with those established in the adult population. Further research with consistent definitions for hearing improvement is needed to improve the understanding and treatment of pediatric SSNHL. Level of Evidence Laryngoscope, 131:425–434, 2021

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sudden Sensorineural Hearing Loss in Children—Management and Outcomes: A Meta‐analysis

2020

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“…The epidemiology of SSNHL in children is unknown as most of the available data are based on rather small case series. Nevertheless, it seems that young children with SSNHL have a poorer prognosis than adolescents (7,8).…”

Section: Introductionmentioning

confidence: 98%

Hereditary bilateral sudden sensorineural hearing loss

Varga¹,

Jovankovičová²,

Hučková³

et al. 2019

BLL

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The aim of our study is to demonstrate a causal link between two distinct diagnoses, the hereditary hearing loss, and the sudden sensorineural hearing loss. BACKGROUND: Sudden sensorineural hearing loss is an emergency condition in otolaryngology and a rare diagnosis in childhood. Most often it only affects one ear and its cause remains unknown. METHODS: We present a clinical study of a 10-year-old female patient presenting with bilateral sudden sensorineural hearing loss analyzed by Sanger sequencing of the GJB2 gene. RESULTS: The subject was referred to the hospital for bilateral sudden hearing loss which developed 3 days before the admission. Audiometric testing confi rmed bilateral asymmetric sensorineural hearing loss. All routine diagnostic procedures including MRI and CT imaging showed normal results. She was treated with intravenous and intratympanic corticosteroids followed by hyperbaric oxygen therapy with partial hearing recovery in one ear. DNA analysis of the GJB2 gene identifi ed biallelic c.35delG deletion. The subject had no other affected family members and her auditory development to that time was normal. CONCLUSION: Our fi nding extends the knowledge on phenotype variability in GJB2 variants. We suggest considering genetic testing in pediatric cases of bilateral sudden sensorineural hearing loss (Tab. 1, Fig. 4, Ref. 24).

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