Side Effects of Transplant Immunosuppressive Therapy in Post Renal Transplant Recipients, Mazandaran, Northern Iran

Abstract

Background: Post-kidney transplant survival relies on patient adherence to the intake of immunosuppressive medication. This study was performed to investigate complications associated with immunosuppressive therapy in renal transplantation. Methods: This cross-sectional study was conducted on 188 transplanted patients in Shahid Beheshti hospital of Babol in 2013. Check list and demographic questionnaire for data collecting were used. Then the data using were analyzed in SPSS.18 software by using chi-square test.

Gender disparity among renal transplant recipients receiving immunosuppressive therapy

“…The main adverse effects were strange hair growth, gingival hyperplasia, easy bruising, slow curing, weight gain, hypertension, sexual dysfunction, bone pain, weakness of the muscles, and headaches, and these adverse effects had negative effects on health-related quality of life. [2] These findings are consistent with the current study results.…”

“…Over the past decade, major advancement has been made to improve graft and patient life within renal transplantation. [2] Renal transplantation is considered the safest and the best current management option for patients with end-stage renal disease (ESRD) because it prolongs a patient's life, decreases morbidity, and consequently improves the quality of life (QOL). [3,4] On the other hand, researchers [5][6][7][8] agreed that renal transplantation is becoming the first line of management for patients with ESRD, regardless of age, when compared to renal dialysis.…”

“…Mild side effects include nausea, discomfort, appetite loss while, severe side effects may include: severe diarrhea, nephrotoxicity, hyperlipidemia, and diabetes. [2] Quality of life has been known as the gap between the prospect and the current condition of an individual. Healthrelated quality of life represents the functional effect of an illness and its management upon the patient as perceived by the patient himself.…”

Depressive symptoms and associated factors among kidney transplant recipients

“…In the current study, symptom distress was one of the predictors of depression. The prevalence of multiple physical challenges such as fatigue, increase in weight, headache, swelling, gingivitis, facial changes, and hair loss are due to the side effects of immunosuppressive drugs (16,17). In addition, fear of transplant rejection (3), and multiple social problems can intensify depression in these patients.…”

“…On the other hand, survival after kidney transplantation depends on adherence to immunosuppressive drugs. The findings showed that almost all KT recipients suffered from at least one side effect of immunosuppressive drugs, which requires diagnosis, control and treatment (16). These patients may experience conditions such as weight gain, facial changes, leg edema, and hair loss (17).…”