Side effects of the Pfizer BioNTech vaccine in health workers of a hospital in the southeast of Mexico

Abstract

Introduction: The goal of this study was to evaluate the side effects of application of the Pfizer BioNTech vaccine on the workers at a Mexican hospital.
 Methodology: A cross-sectional study was carried out, in which 1351 workers from a tertiary care center in the Mexican southeast were included. Sociodemographic data, comorbidities, and side effects after the Pfizer BioNTech vaccine were obtained through an online survey. The variables were analyzed through descriptive statistics. The presence or absence of side effects was analyzed through the Chi-square test or t-test, as appropriate. The result was considered statistically significant at p < 0.05.
 Results: A total of 1351 health workers participated in the online survey. The mean age was 37.8 ± 10.9 years and 56.4% were women. Among them, 8.2% suffered from high blood pressure. In addition, 76.7% manifested pain in the application area. The presence of side effects was associated with the female gender (p < 0.01). Side effects were more prevalent in younger age (37.2 ± 10.7) than older age (41.5 ± 10.8) (p < 0.01). There was no association with the presence of comorbidities (p > 0.05).
 Conclusions: The data suggest that pain in the application area is the most frequent side effect among workers in a Mexican hospital who received the Pfizer BioNTech vaccine against COVID-19. In addition, we observed sialorrhea as a side effect in the studied population and this had not previously been reported. The highest number of adverse events occurred between 24 to 72 hours after application.

Acute adverse events of Sars-CoV2 vaccines: Experiences from a health care worker vaccination campaign in two municipal hospitals in northwest Germany

“…Focusing on health care workers, vaccination appears highly effective and safe [15] . However, reports from around the globe mostly indicate rates of adverse events which are similar or even higher than in our cohort ranging from 77% in a collection from Mexico up to 98% in a cohort from the U.S. [16] , [17] , [18] , [19] with a substantial contribution of psychological and social effects triggered by the pandemic [20] . Interestingly, it could be reconfirmed that high rates of adverse events correlate with post-vaccination antibody levels [18] .…”

Symptomatology Following Covid-19 Vaccination – A Cross-Sectional Study in Central India

“…While research from Mexico has reported common side effects (health-care workers) after Pfizer-BioNTech vaccine administration as pain at the vaccination site (76.7%), headache (32.9%), and fatigue (30.3%). [23]. The current research discovered that 2.2% of participants contracted the disease after the second dose of the COVID-19 vaccine and 3.4% after the first dose.…”

“…The prevalent vaccine type in the current study is Covishield, but most of the studies conducted around the world are based on, Sinopharm, Pfizer (BNT162b2), Moderna, CoronaVac, and various other vaccines [21][22][23][24][25]. Participants in the studies conducted in Uganda and Ethiopia were received the AstraZeneca vaccine; the current study's vaccine mixture was not used in those studies [26,27].…”