Side Effects of Nasal Continuous Positive Airway Pressure in Sleep Apnea Syndrome

Pépin, Jean‐Louis; Léger, P; Veale, D; Langevin, Brigitte; Robert, Dominique; Lévy, Patrick

doi:10.1378/chest.107.2.375

Cited by 355 publications

(255 citation statements)

References 23 publications

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“…[5][6][7][8][9][10] The adequacy and comfort of mask fit, the appropriate pressure, and the management of adverse effects strongly influence efficacy. 2,4,21 We believe that any immediately available information that helps improve patient outcomes is valuable.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] This is usually administered via nasal mask (nasal CPAP), which is perceived as more comfortable than oronasal mask. 5 Adverse effects are common, [6][7][8][9][10] and overall adherence to CPAP therapy is poor, because patients often abandon therapy within the first month. [11][12][13][14] The monitoring of CPAP therapy is now possible with the advent of CPAP machines that gather statistical and graphical information on use and efficacy.…”

Section: Introductionmentioning

confidence: 99%

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Leak Profile Inspection During Nasal Continuous Positive Airway Pressure

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leak Profile Inspection During Nasal Continuous Positive Airway Pressure

et al. 2011

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“…The major clinical challenge however remains improving long-term adherence to CPAP [6]. Among the side effects caused by CPAP, undesirable nasal symptoms such as congestion, dryness or rhinorrhea are particularly prevalent and can significantly compromise compliance [7]. Several mechanisms may be potentially involved in the development of nasal discomfort with CPAP but they have been described only in healthy volunteers [8][9][10] and in a rodent model [11].…”

mentioning

confidence: 99%

Nasal inflammation in sleep apnoea patients using CPAP and effect of heated humidification

Koutsourelakis¹,

Vagiakis²,

Perraki³

et al. 2010

European Respiratory Journal

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Nasal continuous positive airway pressure (CPAP) can cause undesirable nasal symptoms, such as congestion to obstructive sleep apnoea (OSA) patients, whose symptoms can be attenuated by the addition of heated humidification. However, neither the nature of nasal symptoms nor the effect of heated humidification on nasal pathophysiology and pathology are convincingly known.20 patients with OSA on nasal CPAP who exhibited symptomatic nasal obstruction were randomised to receive either 3 weeks of CPAP treatment with heated humidification or 3 weeks of CPAP treatment with sham-heated humidification, followed by 3 weeks of the opposite treatment, respectively. Nasal symptom score, nasal resistance, nasal lavage interleukin-6, interleukin-12 and tumour necrosis factor-a and nasal mucosa histopathology were assessed at baseline and after each treatment arm.Heated humidification in comparison with sham-heated humidification was associated with decrease in nasal symptomatology, resistance and lavage cytokines, and attenuation of inflammatory cell infiltration and fibrosis of the nasal mucosa.In conclusion, nasal obstruction of OSA patients on CPAP treatment is inflammatory in origin and the addition of heated humidification decreases nasal resistance and mucosal inflammation.

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“…Especially when impaired nasal breathing (nasal obstruction due to the shape of the nasal cavity or nasal diseases) is observed, careful examination is important. Without appropriate care, symptoms such as intranasal pain, intranasal dryness, and nasal bleeding may occur, or nCPAP may become impossible because of the development of mouth breathing 3,11,14) . Likewise, mouth breathing easily develops in the presence of enlarged tonsils, and this may lead to failure of nCPAP because the full effect cannot be obtained.…”

Section: Discussionmentioning

confidence: 99%

Approach to Obstructive Sleep Apnea Syndrome at Tokyo Dental College Ichikawa General Hospital

Nakajima

Hayama

Ohkushi

et al. 2004

Bull. Tokyo Dent. Coll.

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In this communication, we report the current status of OSAS (Obstructive Sleep Apnea Syndrome) in the southern region of Higashikatsushika around Ichikawa City, our effort to improve patient QOL as well as to establish diagnostic and therapeutic methods, and the results of a comparison of therapeutic options with the focus on improvement of compliance by using nCPAP (nasal continuous positive airway pressure). We examined 112 patients who visited the Otolaryngology Department at Tokyo Dental College, Ichikawa General Hospital, with the chief complaint of nocturnal snoring or sleep apnea from January 2001 to April 2003 and underwent all-night PSG (polysomnography). Based upon the results of these all-night PSGs, 89 and 23 patients were diagnosed as having OSAS and simple snoring, respectively. Using the AHI classification of severity, 58 and 31 patients were assessed as having severe OSAS and mild OSAS, respectively. (1) nCPAP was tried in 61 patients, and 39 patients (63%) were able to continue it. After the introduction of nCPAP, surgery was performed in 18 patients (30%). As a result, weaning from nCPAP was successfully achieved in 10 cases, compliance with nCPAP was improved in six cases, alleviation of symptoms (decreased pressure) was seen in one case, and aggravation was noted in one case. In addition, four patients (7%) unilaterally discontinued nCPAP. (2) Surgery was performed in 34 patients, and 18 of them had surgery after nCPAP was tried. (3) We asked the dental department to make OAs (oral appliances) for 31 patients but seven of them did not attend the department, so a total of 24 patients used OAs. Fourteen patients (58%) were able to tolerate an OA for 3 months or more. Based on these results, we are hoping to achieve a better control of OSAS by combining nCPAP and other modalities.

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Side Effects of Nasal Continuous Positive Airway Pressure in Sleep Apnea Syndrome

Cited by 355 publications

References 23 publications

Leak Profile Inspection During Nasal Continuous Positive Airway Pressure

Leak Profile Inspection During Nasal Continuous Positive Airway Pressure

Nasal inflammation in sleep apnoea patients using CPAP and effect of heated humidification

Approach to Obstructive Sleep Apnea Syndrome at Tokyo Dental College Ichikawa General Hospital

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