Side Effects of Dental Metal Implants: Impact on Human Health (Metal as a Risk Factor of Implantologic Treatment)

Přikrylová, Jana; Procházková, J; Podzimek, Štěpán

doi:10.1155/2019/2519205

Cited by 28 publications

(18 citation statements)

References 24 publications

(59 reference statements)

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“…However, the metallic color of the titanium implant or abutment is visible through the soft peri-implant tissue, and this results in an unpleasant aesthetic outcome [ 7 ]. The long-term existence of metal materials in humid oral environments can easily lead to chemical corrosion [ 8 ]; additionally, patients with metallic allergies will have a greater risk of developing allergic reactions to metals or alloy materials [ 9 ]. Therefore, in the past decade, the choice of materials for dental implants or abutment has gradually shifted to aesthetic materials.…”

Section: Introductionmentioning

confidence: 99%

Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

et al. 2021

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Poly-ether-ether-ketone (PEEK) is an aesthetically pleasing natural material with good biocompatibility and shock absorption characteristics. The application of PEEK as a dental implant or abutment is expected to reduce the risk of failure and enhance aesthetics. Given that approximately one in 15 patients have allergic reactions to antibiotics, photodynamic therapy (PDT) has been gaining attention as an alternative treatment. Herein, the applicability of PEEK dental implants or abutments was investigated using material analyses, biofilm formation assay, and cell viability tests. The possible use of PDT for peri-implant mucositis was evaluated with the biofilm removal assay. The obtained data were analyzed based on the multivariate analysis of variance, paired t-tests, and the Pearson correlation coefficient (α = 0.05). The results revealed that PEEK was significantly less conducive to the formation of biofilms with S. mutans and A. actinomycetemcomitan (p < 0.001) but exhibited comparable MG-63 (human osteoblast-like) osteoblast cell viability (p > 0.05) to the other materials. PDT had similar antimicrobial efficacy and yielded similar biofilm removal effects to antibiotics. Altogether, these findings suggest that PEEK has attractive features and can serve as an alternative material for dental implants or abutments. In cases where peri-implant mucositis occurs, PDT can be used as an accessible therapeutic approach.

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Section: Introductionmentioning

confidence: 99%

Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

et al. 2021

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“…However, long-term biological requirements, especially biocompatibility and resistance to bacterial contamination, may be problematic. Titanium is considered to be the most biocompatible material thanks to its high corrosion resistance [7][8][9]. On the other hand, it has been reported that its particles may diffuse to the surrounding tissues causing allergic reactions, cytotoxicity, or pro-inflammatory responses [7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Titanium is considered to be the most biocompatible material thanks to its high corrosion resistance [7][8][9]. On the other hand, it has been reported that its particles may diffuse to the surrounding tissues causing allergic reactions, cytotoxicity, or pro-inflammatory responses [7][8][9][10][11][12][13][14]. Therefore, studies involving titanium alloys must be conducted with high accuracy.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility to biofilm formation on 3D-printed titanium fixation plates used in the mandible: a preliminary study

Pałka¹,

Mazurek-Popczyk

Arkusz

et al. 2020

Journal of Oral Microbiology

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Background: In the oral and maxillofacial surgery, fixation plates are commonly used for the stabilization of bone fragments. Additive manufacturing has enabled us to design and create personalized fixation devices that would ideally fit any given fracture. Aim: The aim of the present preliminary study was to assess the susceptibility of 3D-printed titanium fixation plates to biofilm formation. Methods: Plates were manufactured using selective laser melting (SLM) from Ti-6Al-4 V. Reference strains of Streptococcus mutans, Staphyloccocus epidermidis, Staphylococcus aureus, Lactobacillus rhamnosus , and Candida albicans , were tested to evaluate the material’s susceptibility to biofilm formation over 48 hours. Biofilm formations were quantified by a colorimetric method and colony-forming units (CFU) quantification. Scanning electron microscopy (SEM) visualized the structure of the biofilm. Results: Surface analysis revealed the average roughness of 102.75 nm and irregular topography of the tested plates. They were susceptible to biofilm formation by all tested strains. The average CFUs were as follows: S. mutans (11.91 x 10 7 ) > S.epidermidis (4.45 x 10 7 ) > S. aureus (2.3 x 10 7 ) > C.albicans (1.22 x 10 7 ) > L. rhamnosus (0.78 x 10 7 ). Conclusions: The present preliminary study showed that rough surfaces of additively manufactured titanium plates are susceptible to microbial adhesion. The research should be continued in order to compare additively manufactured plates with other commercially available osteotomy plates. Therefore, we suggest caution when using this type of material.

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“…These metals are bioinert but in some cases they induce immunological responses, including allergies. Another disadvantage is that they are not biodegradable [93,94].…”

Section: Biomaterialsmentioning

confidence: 99%

The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration

d’Angelo

Benedetti

Tupone

et al. 2019

Cells

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The mechanotransduction is the process by which cells sense mechanical stimuli such as elasticity, viscosity, and nanotopography of extracellular matrix and translate them into biochemical signals. The mechanotransduction regulates several aspects of the cell behavior, including migration, proliferation, and differentiation in a time-dependent manner. Several reports have indicated that cell behavior and fate are not transmitted by a single signal, but rather by an intricate network of many signals operating on different length and timescales that determine cell fate. Since cell biology and biomaterial technology are fundamentals in cell-based regenerative therapies, comprehending the interaction between cells and biomaterials may allow the design of new biomaterials for clinical therapeutic applications in tissue regeneration. In this work, we present the most relevant mechanism by which the biomechanical properties of extracellular matrix (ECM) influence cell reprogramming, with particular attention on the new technologies and materials engineering, in which are taken into account not only the biochemical and biophysical signals patterns but also the factor time.

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Side Effects of Dental Metal Implants: Impact on Human Health (Metal as a Risk Factor of Implantologic Treatment)

Cited by 28 publications

References 24 publications

Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis

Susceptibility to biofilm formation on 3D-printed titanium fixation plates used in the mandible: a preliminary study

The Role of Stiffness in Cell Reprogramming: A Potential Role for Biomaterials in Inducing Tissue Regeneration

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