Side-effects and complications of foam sclerotherapy of the great and small saphenous veins: a controlled multicentre prospective study including 1025 patients

Jl, Gillet; Guedes, JM; Jj, Guex; Hamel-Desnos, C; Schadeck, M.; Lauseker, Michael; Allaert, François-André

doi:10.1258/phleb.2008.008063

Cited by 136 publications

(179 citation statements)

References 45 publications

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“…In addition, neurologic complications including transient ischemic attacks, transient visual disturbance and transient confusional state and migraine have been described [40,42] . Gillet et al [40] , in a multicenter prospective study of foam sclerotherapy of great and small saphenous veins including 1,025 patients, reported a case of transient ischemic attack in a 52-year-old woman presenting with dysarthria for 30 s and paresthesia of the left hand for 30 min and clinical recovery within 30 min.…”

Section: Cerebrovascular Aementioning

confidence: 99%

“…Gillet et al [40] , in a multicenter prospective study of foam sclerotherapy of great and small saphenous veins including 1,025 patients, reported a case of transient ischemic attack in a 52-year-old woman presenting with dysarthria for 30 s and paresthesia of the left hand for 30 min and clinical recovery within 30 min. In the same series, 7 cases of isolated visual disturbance as well as 5 cases of chest pressure combined with visual disturbance were reported.…”

Section: Cerebrovascular Aementioning

confidence: 99%

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Safety Concerns for Sclerotherapy of Telangiectases, Reticular and Varicose Veins

Yiannakopoulou¹

2016

Pharmacology

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Background: Sclerotherapy has been extensively used in the treatment of valvular insufficiency of superficial veins. Although sclerotherapy seems safe, reports of serious adverse events (AE) have been published. This paper aims to review AE of sclerosing agents. Methods: Electronical databases were searched for identifying articles on local, serious and long-term AE of sclerotherapy. Results: Hyperpigmentation and matting are the most often local AE of sclerotherapy. Other local AE include superficial thrombophlevitis, pyoderma gangrenosum, pain, ulcer formation, and hypertrichosis. Local AE can be serious, that is, it can include cutaneous necrosis, intra-arterial injection with subsequent acute ischemia that can lead to amputation, and necrotizing fasciitis. Most data on systemic AE of sclerotherapy are extracted from case series and case reports. Systemic AE include neurological complications, such as ischemic stroke, transient ischemic attack, visual disturbances and cardiac toxicity, that is, myocardial infarction, Takotsubo cardiomyopathy, chest tightness, pulmonary embolism, deep vein thrombosis, septicemia, anaphylaxis. It is difficult to estimate the frequency of serious systemic AE of sclerotherapy. Conclusion: Physicians practicing sclerotherapy should be aware of the possible local and systemic AE of sclerotherapy, inform patients accordingly and be prepared for the appropriate management of the rare but possibly lethal serious AE.

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Section: Cerebrovascular Aementioning

confidence: 99%

Section: Cerebrovascular Aementioning

confidence: 99%

Safety Concerns for Sclerotherapy of Telangiectases, Reticular and Varicose Veins

Yiannakopoulou¹

2016

Pharmacology

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“…These neurological symptoms have been associated with a patent foramen ovale (PFO). 41 The authors argue that despite a relatively high estimate of PFO in the adult population (up to 25%), the rate of neurological complications following FS appear to be low. 42 Tissue necrosis, telangiectasia matting, and skin discoloration have also been observed after FS.…”

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confidence: 99%

Endovenous Management of Varicose Veins

et al. 2018

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Abstract:Varicose veins are a very common condition and have been the subject of a recent proliferation of treatment modalities. The advent of the endovenous treatment era has led to a confusing array of different techniques which can be daunting when making the transition from traditional surgery. All modalities offer excellent results in the right situation and each has their own treatment profile. Thermal ablation techniques have matured and have a reassuring and reliable outcome, but the arrival of non-thermal techniques has delivered further options for both patient and surgeon. This article provides an overview of the different treatment devices and modalities available to the modern superficial vein surgeon and details the currently available evidence and summation analysis to help surgeons to make an appropriate treatment choice for their patients. Keywords:Endovenous ablation, varicose veins, venous disease, radiofrequency, sclerotherapy, cyanoacrylate Page 1 of 24 http://mc.manuscriptcentral.com/ang Angiology 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 IntroductionVaricose veins are a common condition affecting up to one-third of the population, with detrimental effects on the quality of life (QoL). 1-2Until the past decade, the traditional technique of saphenofemoral or saphenopopliteal ligation with or without vein stripping has been the gold standard treatment of truncal saphenous incompetence. This usually necessitates either general or regional anaesthesia. 3 Although surgery provides good outcomes, it is associated with ecchymosis, hematoma, tenderness, 4 infection, nerve injury, delayed return to normal activity 3-5 and routinely necessitates narcotic analgesia. 3In response to the need for less invasive treatment, endovenous treatments, namely radio-frequency ablation (RFA) and endovenous laser ablation (EVLA) have been developed. These have led to a reduction in morbidity compared with open surgery, 4-6 by reducing postoperative pain, providing faster recovery time, improving QoL and lowering complication rates. 7-8More recently, new non-thermal, non-tumescent (NTNTs) treatments have been developed to overcome the shortcomings associated with thermal ablation. Both thermal and non-thermal treatments are discussed in this review. Thermal-Tumescent Ablative ManagementSince 1999, endovenous thermal ablation, in the form of RFA and EVLA have been developed. More recently, endovenous microwave ablation (EMA) and steam vein sclerosis (SVS) have also been introduced. Their mechanism of action involves using heat to cause thermal damage to the venous wall. Radio-frequency ablation (RFA)The practice of RFA utilizes radio-frequency waves to produce thermal energy (85-120°C) resulting in endothelial damage and sealing of the incompetent vein ( Figure 1). In 1999, the U.S. Food and Drug Administration (FDA) approved RFA for...

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“…Nevertheless, thrombotic complications following sclerotherapy typically present with delayed onset [20,21], while cardiac symptoms in all of reported cases arose within a few minutes following sclerotherapy.…”

Section: Discussionmentioning

confidence: 90%

“…It has been described in 1.1 % of cases in a large prospective cohort of patients treated with UGFS [21], and usually disappeared within 5 minutes. A subgroup of these patients undergoing specialised cardiological examination did not present any abnormality.…”

Section: Discussionmentioning

confidence: 97%

Myocardial infarction after ultrasoundguided foam sclerotherapy for varicose veins - a case report and review of the literature of a rare but serious adverse event

Engelberger

Ney

Clair

et al. 2016

Vasa

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Side-effects and complications of foam sclerotherapy of the great and small saphenous veins: a controlled multicentre prospective study including 1025 patients

Cited by 136 publications

References 45 publications

Safety Concerns for Sclerotherapy of Telangiectases, Reticular and Varicose Veins

Safety Concerns for Sclerotherapy of Telangiectases, Reticular and Varicose Veins

Endovenous Management of Varicose Veins

Myocardial infarction after ultrasoundguided foam sclerotherapy for varicose veins - a case report and review of the literature of a rare but serious adverse event

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