Side Effects after mRNA COVID-19 Vaccine as a Booster in Health Workers

Abstract

Background: In Indonesia, around 400 health workers died due to Covid-19 between June-July 2021, therefore the health workers need to be given further immunity. Health workers were among the first to get a booster shoot. However, they may experience side effects after vaccination. We aimed to describe side effects of Moderna vaccine as a booster in health workers.
 Methods: A cross sectional study was conducted on health workers who received mRNA Covid-19 vaccine booster (Moderna) at Sulianti Saroso Infectious Disease Hospital, Indonesia and had filled the questionnaire assessing side effects form. We associated the form of the questionnaire assessing side effects from the originating source of hospital immunization unit in September 2021.
 Results: A total of 101 health workers who received mRNA Covid-19 vaccine booster in Jul-Aug 2021 were included. Most of health worker experienced more than 3 side effects. The side effects were sore arm (100%); chills (72%); fatigue (57%); headache (53%) and fever (51%), other symptoms (28%). The side effects mostly happened a day of receiving a booster shot (61.4%). There was no association between age, gender, comorbid to amount of side effects (P>0.05).
 Conclusion: Since the public must fulfil the immunization program during pandemic, it is the responsibility of the healthcare provider to inform about the potential side effects and benefits of a new Covid-19 vaccine.

Adverse events following immunization of mRNA-1273 (Moderna) booster vaccine in clerkship students

“…It might be because the number of female respondents is higher than males (74.8% vs 25.2%). This study result is similar with the previous study by Pakki et al among health workers that 45.6% subjects were <35 years, which also indicated gender has no relationship with AEFI [12]. A study by Hidayat et al found that there was a significant relationship between the appearance of AEFI symptoms and a previous history of allergies [19].…”

“…Meanwhile another study in USA showed 89.35% were females and the remaining were males among mRNA-1273 vaccine recipients, with 6.02% belong to the age group between 18-30 years and the mean of the age was 43.76 years [20]. Other study in Indonesia among healthworkers, conducted by Pakki et al showed different results such as female were 67.3%, and male were 33.7%, while 28.7% had history of COVID-19 and 10.9 had comorbidities [12].…”

“…Although, after the primary and booster of COVID-19 vaccination, people can experience adverse events following immunization (AEFI). AEFIs is any unwanted medical events that occur after immunization and do not necessarily have a causal relationship with the use of vaccines [12]. AEFIs is one of the factors related to public perception of vaccine safety, thus the community's decision to accept or reject vaccines.…”

Prevalence and risk factors of adverse effects after the first COVID-19 booster dose: evidence from Greece

“…We found that almost all participants (96%) developed at least one adverse effect after the first booster dose. Literature supports this finding since two other studies found that all participants had adverse effects after the first booster dose [20,21]. Other studies found also high prevalence of adverse effect after the first booster dose ranging from 74.7% to 89% [14–17,22,23].…”

Eggstraordinary health: exploring avian egg proteins and peptides in boosting immunity and health maintenance

“…Affordable and wholesome foods are the preference of most people, while consumption of meat and processed foods has declined. The habits and dietary structure of people have been gradually modified as the demand for eliminating sub-health and preventing the occurrence of diseases has increased [2] . The industries that focus on slowing down aging, improving immunity, and maintaining the health of life, are expected to continue to exhibit a significant rise.…”