Side effect profiles of atypical antipsychotics, typical antipsychotics, or no psychotropic medications in persons with mental retardation

Advokat, Claire; Mayville, Erik A.; Matson, Johnny L.

doi:10.1016/s0891-4222(99)00031-1

Cited by 95 publications

(27 citation statements)

References 14 publications

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“…Many of these disorders and co-occurring conditions lead to the use of chronic, restrictive treatments such as psychotropic medications (Advokat, Mayville, & Matson, 2000;. For all of these reasons just noted, early identification has become a major focus for the field (Matson, Boisjoli, Rojahn, & Hess, 2009;Matson, Mahan, Hess, & Fodstad, 2010;Matson, Fodstad, Mahan, & Sevin, 2009).…”

mentioning

confidence: 99%

Early intervention for autism: Who provides treatment and in what settings

Matson

Konst

2014

Research in Autism Spectrum Disorders

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mentioning

confidence: 99%

Early intervention for autism: Who provides treatment and in what settings

Matson

Konst

2014

Research in Autism Spectrum Disorders

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“…Since their discovery in the 1950s, antipsychotic drugs have been used increasingly in persons with mental retardation accompanied by psychiatric and behavioral disorders (8). With the use of these drugs, in the long run tardive movement disorders began to be seen (4).…”

Section: Discussionmentioning

confidence: 99%

“…TD began to be seen after in the 1950s the first generation of antipsychotics came into use, and the first case was reported in 1957 (1,7,8). In 1964, Faurbye (9) observed the emergence of involuntary motoric movements in psychotic patients under longterm medication and defined these as TD.…”

Section: Introductionmentioning

confidence: 99%

Uzun süre antipsikotik tedavisi alan mental retardasyonlu hastalarda tardiv diskinezi

Can¹,

Nalbant²,

Burhan³

et al. 2016

Dusunen Adam

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Tardive dyskinesia in mentally retarded patients under long-term antipsychotic treatmentObjective: Tardive dyskinesia (TD) is an iatrogenic movement disorder, developing due to prolonged use of dopamine receptor blocking agents, that may affect various parts of the body. In a number of studies, prevalence rates between 5 and 30% have been reported. This study aims to research TD in patients with mental retardation who have been hospitalized for a long time and medicated regularly.Method: Included in this study were 40 patients with a diagnosis of mental retardation comorbid with schzophrenia or other psychotic disorders according to DSM-IV TR that had been hospitalized in the chronic patients' ward of Bakirkoy Training and Research Hospital for Psychiatry, Neurology and Neurosurgery for a long period. Duration and type of antipsychotics both at the time of interview and over the preceding years were recorded. Dyskinesia was assessed using the Abnormal Involuntary Movements Scale (AIMS). We also used the Simpson-Angus Rating Scale (SAS) for Parkinsonism. Akathisia was measured using the Barnes Akathisia Rating Scale (BARS).Results: According to AIMS scores, 9 participants (22.5%) received a diagnosis of TD. There was no significant correlation between the type and duration of ongoing or the longest used treatment and the prevalence of TD. There was a statistically significant correlation between the participants' age and TD (p=0.009). There were no gender differences for TD Conclusion: We found that long-term use of antipsychotics is unrelated with TD, while age is an important risk factor for TD. It can be said that switching from first generation to second generation antipsychotics does not reduce the prevalence of TD.Keywords: Antipsychotics, mental retardation, tardive dyskinesia ÖZET Uzun süre antipsikotik tedavisi alan mental retardasyonlu hastalarda tardif diskinezi Amaç: Tardif diskinezi (TD) uzun süreli dopamin reseptör blokajı oluşturan ilaçlara bağlı olarak gelişen, vücudun çeşitli bölgelerini tutabilen iatrojenik bir hareket bozukluğudur. Yapılan çalışmalarda prevalansının %5 ila %30 aralığında değiştiği görülmektedir. Bu araştırma, ruh sağlığı hastanesinde uzun süredir yatan ve düzenli olarak ilaç almakta olan mental retardasyonlu hastalarda tardiv diskineziyi araştırmayı amaçlamaktadır. Bulgular: AİHÖ puanlarına göre değerlendirildiğinde katılımcıların 9'una (%22.5) TD tanısı kondu. TD tanısı konanlarda geçmişte ya da halen kullanılan antipsikotik türü ve süresi ile TD arasında bir ilişki saptanmadı.Katılımcıların yaşlarıyla TD arasında istatistiksel olarak anlamlı ilişki bulundu (p=0.009). Kadınlarla erkekler arasında TD açısından fark saptanmadı.Sonuç: Araştırmamızda uzun süreli antipsikotik kullanımının TD ile ilişkisiz olduğu, yaşın ise TD riski açısından önemli bir etken olduğu saptanmıştır. Birinci kuşak antipsikotik tedaviden ikinci kuşağa geçmesinin ise TD sıklığını azaltmadığı söylenebilir.

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“…Medication, for example, is commonly used although little data exists to support its use, especially for the core symptoms of the disorder. Also, these drugs, especially antipsychotic medications, can produce chronic and debilitating side effects (Advokat, Mayville, & Matson, 2000;. Similarly, there is debate about whether antipsychotic medications are effective for challenging behaviors among persons with developmental disabilities .…”

Section: Treatmentsmentioning

confidence: 99%