Side-effect profile of sildenafil citrate (Viagra) in clinical practice

Nasal Obstruction as a Common Side-Effect of Sildenafil Citrate

“…We do not know the reason exactly, but nasal obstruction is not seen in all patients using Sildenafil (Moreira et al 2000).…”

“…As a biologic mediator serving many functions, NO is present in nasal cavities and paranasal sinuses (Lundberg 1996). In addition to human corpus cavernosum smooth muscle, PDE-5 is also found in other tissues including vascular, visceral smooth muscle, and skeletal muscle (Moreira et al 2000). In keeping with the known functions of NO as a vasodilatator in the pulmonary and systemic vascular beds (Wallis et al 1999), NO could potentially cause vasodilation in nasal cavity.…”

Creative-dynamic image synthesis: a useful addition to the treatment options for impotence

“…The adverse reactions most commonly observed were flushing (30.8%), headache (25.4%), nasal congestion (18.7%), and heartburn (10.5%). 19 CDB, creative-dynamic image synthesis, now provides a viable psychotherapeutic alternative to medication for the treatment of ED, since the desired results can be achieved in only four to seven sittings. The advantage of this therapy is that it offers an effective treatment option without the abovedescribed undesirable drug side-effects and at a fraction of the cost of a drug-based therapy.…”

Sildenafil citrate: lessons learned from 3 years of clinical experience

“…48 In addition, sildenafil was Sildenafil citrate: lessons learned DG Hatzichristou not associated with adverse hemodynamic effects in patients with ischemic heart disease and chronic heart failure 47 and was equally effective and well tolerated in patients taking antihypertensive agents as in those patients not taking blood pressure medication. 49,50 Aside from the known contraindication of sildenafil in nitrate users, caution should also be exercised when patients with cardiovascular disease resume sexual activity as a result of receiving any treatment for ED.…”