Side-effect of Phenindione

Abstract

Side-effect of Phenindione SIR,-I would like to bring to the attention of other physicians a brownish-yellow discoloration of the fingernails which became evident in one of my patients who was treated with long-term anticoagulants for coronary disease. This patient was started on phenindione in April, 1962, and put on a long-term maintenance dose on May 2, 1962, but in August, 1962, he noted that the peripheral third of every fingernail in the hands had become brownish-yellow in colour, and this has persisted up to the present date. He is still on a maintenance therapy of "dindevan " (phenindione) 75 mg. daily. I would be very interested to learn if other physicians have noted this unusual side-effect of phenindione.-I am, etc.