Side dependent effects of the human amnion on angiogenesis

Niknejad, Hassan; Paeini-Vayghan, Ghodsieh; Tehrani, Fatemeh Asi; Khayat-Khoei, Mahsa; Peirovi, Habibollah

doi:10.1016/j.placenta.2013.02.001

Cited by 83 publications

(70 citation statements)

References 29 publications

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“…Its histological structure develops from conception to birth, and it is resilient, smooth, shiny, flexible, and slender [20][21] . AM consists of five layers [22][23] , including an internal monolayer of non-adhesive cuboidal epithelial cells that are rich in immunomodulatory cytokines and epithelial growth factors. Hemidesmosomes connect this layer to the second, which is a thick and resistant basal layer formed primarily of type-IV collagen and laminin.…”

Section: Discussionmentioning

confidence: 99%

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Amniotic membrane as a biological dressing in infected wound healing in rabbits

Duarte

Duval-Araujo

2014

Acta Cir. Bras.

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PURPOSE:To investigate amniotic membrane as a biological dressing in infected wound healing in rabbits. METHODS:The use of preserved amniotic membranes (AMs) was examined using 15 rabbits with experimentally induced wound infections on their backs. Healing was histologically evaluated during different phases including inflammation, granulation, epithelialization, and fibroplasia. The animals were distributed into three groups for histological study at seven, 14, 21, and 28 days postwound induction. Group A did not receive treatment: the wound was left exposed and dry; Group B received a daily exposure treatment with collagenase; and Group C received one AM, which also remained exposed. RESULTS:A marked reduction of the inflammatory phase was observed in Group C at 21 days, and the granulation phase of this healing increased at 14 days. Epithelialization was similar among the three groups, and fibroplasia was more pronounced in Group C at 14 days. Furthermore, gradual collagen organization also began for the animals in Group B at 14 days. CONCLUSION:The amniotic membrane did not significantly alter the inflammation, epithelialization, or fibroplasia phases but did increase angiogenesis up to Day 14 compared with the dry dressing and collagenase treatments.

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Section: Discussionmentioning

confidence: 99%

“…The second layer adheres to a third thin layer of connective tissue that underlies the stromal matrix, which is completely avascular and divided into three additional layers: a compact layer of collagen, a layer of fibroblasts, and a spongy layer [22][23] .…”

Section: Discussionmentioning

confidence: 99%

Amniotic membrane as a biological dressing in infected wound healing in rabbits

Duarte

Duval-Araujo

2014

Acta Cir. Bras.

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“…This membrane is proven to have special characteristics such as antiangiogenic, immunoregulatory and pro-apoptotic [5,6] as well as antimicrobial, anti-fibrosis, and low immunogenicity properties [7]. The AM owes these properties to its unique histologic features of having two different types of stem cells: A single layer of Amniotic Epithelial Stem Cells (AESCs) on a thick basement membrane, and Amniotic Mesenchymal Stem Cells (AMSCs) in an avascular stroma.…”

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confidence: 99%

“…Providing a proper blood supply for tumor cells is a key element in tumor growth and metastasis [5] and the AM is believed to possess anti-angiogenesis properties [5,6,8,9,12]. There are reports of antiangiogenic factors such as collagen XVIII, thrombospondin-1, interleukin (IL)-1 receptor antagonist, IL-10 and tissue inhibitor of metalloprotease (TIMP-1, TIMP-2, TIMP-3, and TIMP-4) being mainly produced by the AM-derived Epithelial Stem Cells [12].…”

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confidence: 99%

“…Niknejad et al evaluated the role of AM in angiogenesis more thoroughly using an aorta ring assay and demonstrated different angiogenesis properties for AM based on the attached stem cells on the membrane. In the presence of AESCs, no capillary formation was reported even though AMSCs were present; whereas the AM could induce angiogenesis when the AESCs were scraped and only the AMSCs were remaining [5,6]. This suggests that the AESCs are the main cells responsible for the antiangiogenesis properties of the AM.…”

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Role of Stem Cells in the Anti-tumor Effects of the Human Amniotic Membrane

Khayat-Khoei¹

2015

J Cytol Histol

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Dehydrated human amniotic membrane regulates tenocyte expression and angiogenesis in vitro: Implications for a therapeutic treatment of tendinopathy

Moreno¹,

Massee²,

Koob³

2021

J Biomed Mater Res

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Tendon injuries are among the most common ailments of the musculoskeletal system.Prolonged inflammation and persistent vasculature are common complications associated with poor healing. Damaged tendon, replaced with scar tissue, never completely regains the native structural or biomechanical properties. This study evaluated the effects of micronized dehydrated human amnion/chorion membrane (μdHACM) on the inflammatory environment and hypervascularity associated with tendinopathy. Stimulation of human tenocytes with interleukin-1 beta (IL1β) induced the expression of inflammatory and catabolic markers, resulting in secretion of active MMPs and type 3 collagen that is associated with a degenerative phenotype. Treatment with μdHACM diminished the effects of IL1β, reducing the expression of inflammatory genes, proteases, and extracellular matrix components, and decreasing the presence of active MMP and type 3 collagen. Additionally, a co-culture model was developed to evaluate the effects of μdHACM on angiogenesis associated with tendinopathy. Micronized dHACM differentially regulated angiogenesis depending upon the cellular environment in which it was placed. This phenomenon can be explained in part through the detection of both angiogenic protagonists and antagonists in μdHACM. Observations from this study identify a mechanism by which μdHACM regulates inflammatory processes and angiogenesis in vitro, two key pathways implicated in tendinopathic injuries.

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Side dependent effects of the human amnion on angiogenesis

Cited by 83 publications

References 29 publications

Amniotic membrane as a biological dressing in infected wound healing in rabbits

Amniotic membrane as a biological dressing in infected wound healing in rabbits

Role of Stem Cells in the Anti-tumor Effects of the Human Amniotic Membrane

Dehydrated human amniotic membrane regulates tenocyte expression and angiogenesis in vitro: Implications for a therapeutic treatment of tendinopathy

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